GREMLIN Database
TSCPD - TSCPD domain
PFAM: PF12637 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 94 (91)
Sequences: 17493 (7914)
Seq/√Len: 829.7
META: 0.942

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_K91_E4.0481.00
36_S40_E2.4801.00
41_A83_P2.2201.00
54_V62_K2.1801.00
67_F79_A2.1261.00
49_A59_I2.0771.00
13_V21_P2.0561.00
44_R62_K1.8291.00
42_I45_L1.8171.00
60_V91_E1.7731.00
12_T31_E1.7541.00
45_L59_I1.7381.00
45_L63_L1.6921.00
16_D26_I1.6131.00
12_T29_G1.6031.00
11_I30_K1.4751.00
46_I59_I1.4521.00
34_C68_C1.4471.00
24_V55_P1.4421.00
2_K10_Y1.4291.00
49_A54_V1.3901.00
40_E44_R1.3701.00
67_F77_N1.3651.00
10_Y31_E1.3271.00
3_F11_I1.3271.00
9_L32_G1.3161.00
30_K86_I1.3071.00
27_N52_Y1.3041.00
54_V58_E1.2791.00
26_I43_A1.2311.00
44_R66_I1.2221.00
60_V90_L1.2001.00
5_G8_G1.1971.00
48_L62_K1.1971.00
58_E62_K1.1811.00
3_F6_G1.1811.00
72_V78_K1.1571.00
55_P58_E1.1461.00
45_L49_A1.1351.00
48_L58_E1.1341.00
65_G84_D1.1321.00
64_K88_R1.1211.00
60_V87_A1.1101.00
73_T76_G1.1041.00
64_K87_A1.0951.00
84_D88_R1.0921.00
34_C82_C1.0681.00
66_I83_P1.0511.00
9_L31_E1.0401.00
7_C82_C1.0391.00
16_D22_G1.0381.00
35_I38_N1.0211.00
10_Y25_F0.9951.00
46_I87_A0.9831.00
7_C34_C0.9521.00
22_G51_Q0.9471.00
49_A52_Y0.9361.00
41_A66_I0.9221.00
58_E61_E0.9191.00
52_Y55_P0.9131.00
42_I46_I0.9031.00
16_D20_R0.8971.00
73_T78_K0.8841.00
56_L60_V0.8691.00
68_C82_C0.8681.00
38_N42_I0.8631.00
26_I52_Y0.8601.00
14_N27_N0.8591.00
26_I86_I0.8581.00
44_R52_Y0.8461.00
54_V59_I0.8401.00
65_G80_T0.8391.00
42_I63_L0.8381.00
81_S84_D0.8341.00
59_I63_L0.8101.00
75_G89_A0.8041.00
80_T84_D0.8041.00
23_E47_S0.7951.00
14_N23_E0.7921.00
11_I89_A0.7911.00
41_A63_L0.7881.00
71_G78_K0.7881.00
79_A85_A0.7851.00
27_N36_S0.7821.00
47_S51_Q0.7771.00
13_V89_A0.7741.00
7_C68_C0.7681.00
38_N82_C0.7651.00
52_Y58_E0.7531.00
3_F9_L0.7481.00
38_N83_P0.7461.00
27_N40_E0.7281.00
59_I87_A0.7151.00
60_V64_K0.7141.00
67_F83_P0.7081.00
15_E21_P0.6951.00
73_T77_N0.6821.00
46_I63_L0.6801.00
63_L87_A0.6671.00
2_K9_L0.6631.00
88_R92_E0.6611.00
7_C28_M0.6521.00
40_E66_I0.6481.00
24_V46_I0.6421.00
56_L90_L0.6371.00
29_G32_G0.6371.00
74_F78_K0.6351.00
15_E56_L0.6131.00
19_G24_V0.6101.00
79_A88_R0.6071.00
23_E55_P0.6031.00
23_E51_Q0.6001.00
40_E67_F0.5971.00
57_E61_E0.5951.00
4_K74_F0.5881.00
53_G56_L0.5881.00
19_G55_P0.5731.00
85_A89_A0.5721.00
49_A53_G0.5671.00
39_L43_A0.5631.00
25_F44_R0.5601.00
48_L54_V0.5591.00
34_C38_N0.5521.00
13_V90_L0.5491.00
10_Y14_N0.5481.00
25_F59_I0.5461.00
34_C37_G0.5411.00
37_G67_F0.5401.00
42_I87_A0.5401.00
3_F10_Y0.5261.00
41_A45_L0.5231.00
67_F71_G0.5231.00
74_F77_N0.5181.00
70_S74_F0.5091.00
37_G66_I0.5001.00
48_L51_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r07C 1 0.8511 31.2 0.873 Contact Map
2iz1A 2 0.9043 12.2 0.895 Contact Map
2zydA 2 0.9043 12.1 0.895 Contact Map
3lk4B 1 0.6489 10 0.899 Contact Map
4bbyA 2 0.8191 9.8 0.9 Contact Map
2odiA 1 0.4468 9.8 0.9 Contact Map
5by3A 1 0.9574 9.5 0.9 Contact Map
2i81A 3 0.8511 9.4 0.9 Contact Map
2p4qA 2 0.9043 9.2 0.901 Contact Map
2oa9A 1 0.4149 8 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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