GREMLIN Database
DUF3780 - Protein of unknown function (DUF3780)
PFAM: PF12635 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 185 (166)
Sequences: 710 (401)
Seq/√Len: 31.1
META: 0.887

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_V154_L5.8231.00
62_I103_A4.0341.00
66_V99_L3.9111.00
32_I103_A3.6381.00
52_V103_A3.5971.00
54_L103_A3.2341.00
136_T154_L2.8741.00
73_R126_P2.7551.00
152_K160_E2.5931.00
4_T10_P2.5791.00
51_R137_A2.5020.99
50_L143_A2.4740.99
100_C154_L2.4620.99
62_I106_I2.3860.99
94_L135_M2.2230.99
6_G90_P2.1890.99
21_E88_E2.1580.98
20_V91_V2.0850.98
52_V100_C2.0160.97
71_N82_G1.9720.97
152_K156_Y1.8770.96
9_F14_S1.7840.95
55_D58_K1.7730.95
82_G89_N1.7700.95
153_A157_A1.7320.94
123_G160_E1.7310.94
67_R84_W1.6890.93
79_L133_F1.6510.92
97_K134_T1.5850.91
36_F51_R1.5720.90
35_H47_D1.5640.90
65_E68_R1.4810.87
69_E138_A1.4780.87
152_K159_T1.4580.87
136_T141_G1.4480.86
117_A120_N1.3910.84
9_F15_P1.3590.82
31_L50_L1.3550.82
51_R126_P1.3460.82
108_D146_G1.3110.80
117_A159_T1.2540.77
155_R159_T1.2310.75
113_L160_E1.2040.74
147_G154_L1.2010.74
110_D123_G1.1970.73
29_P53_I1.1880.73
11_P161_N1.1830.73
22_I89_N1.1740.72
24_A52_V1.1730.72
79_L147_G1.1700.72
108_D147_G1.1660.71
119_R135_M1.1560.71
113_L152_K1.1550.71
63_A67_R1.1530.71
16_H36_F1.1460.70
124_L129_R1.1360.69
9_F51_R1.1350.69
150_W153_A1.1260.69
91_V94_L1.1230.68
106_I123_G1.1110.68
9_F13_E1.1010.67
101_V125_R1.0990.67
6_G91_V1.0970.67
63_A99_L1.0890.66
37_G49_E1.0860.66
60_S63_A1.0770.65
66_V117_A1.0770.65
66_V118_I1.0670.64
120_N161_N1.0550.64
134_T138_A1.0360.62
117_A140_T1.0340.62
25_G57_P1.0200.61
21_E31_L1.0190.61
65_E148_R1.0150.60
50_L133_F1.0110.60
39_D58_K1.0110.60
20_V82_G1.0070.60
109_A113_L1.0040.60
54_L62_I1.0030.60
3_K10_P0.9970.59
4_T80_K0.9900.59
45_I51_R0.9520.56
113_L159_T0.9390.54
117_A135_M0.9270.54
140_T162_P0.9270.54
106_I120_N0.9230.53
45_I89_N0.9190.53
46_P89_N0.9180.53
83_R133_F0.9140.52
120_N162_P0.9120.52
70_F84_W0.9120.52
51_R109_A0.9050.52
106_I117_A0.9000.51
41_D133_F0.8990.51
4_T81_T0.8980.51
61_A119_R0.8880.50
46_P143_A0.8740.49
92_D145_D0.8680.49
7_F70_F0.8640.48
51_R61_A0.8590.48
63_A83_R0.8570.48
120_N140_T0.8560.48
42_E53_I0.8520.47
6_G117_A0.8470.47
54_L84_W0.8470.47
64_D152_K0.8450.47
17_H120_N0.8390.46
91_V135_M0.8340.46
120_N134_T0.8290.46
22_I87_G0.8240.45
92_D100_C0.8160.45
64_D67_R0.8160.45
93_R125_R0.8120.44
7_F20_V0.8100.44
41_D46_P0.8090.44
25_G81_T0.8070.44
89_N125_R0.8020.43
76_A139_A0.7980.43
67_R126_P0.7950.43
64_D95_L0.7950.43
42_E45_I0.7940.43
123_G161_N0.7910.43
28_G43_E0.7900.43
6_G49_E0.7890.42
15_P60_S0.7830.42
66_V91_V0.7820.42
117_A155_R0.7800.42
90_P111_P0.7720.41
23_P26_R0.7710.41
48_D58_K0.7580.40
20_V32_I0.7570.40
118_I140_T0.7500.39
149_G153_A0.7500.39
25_G30_V0.7450.39
23_P87_G0.7430.39
30_V118_I0.7420.39
36_F89_N0.7390.39
31_L53_I0.7370.38
120_N139_A0.7350.38
110_D113_L0.7350.38
31_L75_K0.7340.38
10_P92_D0.7320.38
16_H34_E0.7270.38
41_D45_I0.7250.37
16_H19_L0.7210.37
140_T148_R0.7150.37
15_P40_G0.7070.36
74_L95_L0.7070.36
123_G137_A0.7070.36
21_E35_H0.7060.36
69_E72_R0.7050.36
27_T86_T0.7010.36
4_T51_R0.6980.35
115_P165_E0.6970.35
108_D155_R0.6920.35
89_N94_L0.6880.35
42_E81_T0.6860.35
4_T15_P0.6860.35
102_L107_E0.6850.34
8_G18_F0.6800.34
37_G82_G0.6740.34
10_P68_R0.6680.33
138_A161_N0.6650.33
82_G124_L0.6640.33
147_G152_K0.6640.33
153_A158_L0.6630.33
148_R160_E0.6620.33
80_K148_R0.6550.32
25_G28_G0.6530.32
31_L41_D0.6500.32
52_V133_F0.6500.32
97_K135_M0.6460.32
118_I123_G0.6450.32
111_P114_I0.6420.31
134_T159_T0.6380.31
93_R139_A0.6350.31
115_P140_T0.6330.31
140_T155_R0.6330.31
12_E27_T0.6260.30
14_S38_W0.6250.30
23_P89_N0.6250.30
19_L29_P0.6190.30
61_A135_M0.6180.30
49_E139_A0.6160.30
134_T161_N0.6150.30
101_V116_V0.6110.29
30_V136_T0.6100.29
74_L82_G0.6070.29
47_D106_I0.6070.29
80_K144_E0.6060.29
97_K136_T0.6030.29
20_V23_P0.6010.29
17_H20_V0.5970.28
79_L86_T0.5960.28
49_E101_V0.5950.28
8_G11_P0.5920.28
10_P77_A0.5920.28
160_E163_V0.5910.28
49_E76_A0.5900.28
131_W157_A0.5870.28
58_K114_I0.5870.28
67_R75_K0.5850.28
20_V84_W0.5830.27
41_D44_G0.5820.27
162_P165_E0.5810.27
49_E133_F0.5780.27
57_P61_A0.5770.27
51_R101_V0.5720.27
120_N123_G0.5720.27
119_R140_T0.5690.27
136_T156_Y0.5680.27
126_P133_F0.5660.26
70_F126_P0.5640.26
14_S17_H0.5630.26
50_L53_I0.5630.26
58_K94_L0.5600.26
58_K111_P0.5590.26
61_A115_P0.5580.26
32_I91_V0.5570.26
62_I80_K0.5560.26
32_I60_S0.5550.26
132_L154_L0.5550.26
37_G51_R0.5550.26
35_H51_R0.5520.26
3_K53_I0.5490.25
7_F17_H0.5480.25
28_G41_D0.5440.25
94_L133_F0.5440.25
16_H52_V0.5420.25
99_L113_L0.5410.25
8_G12_E0.5400.25
58_K155_R0.5400.25
57_P81_T0.5350.24
138_A162_P0.5290.24
11_P83_R0.5280.24
6_G85_K0.5260.24
58_K108_D0.5240.24
72_R133_F0.5230.24
23_P68_R0.5230.24
97_K120_N0.5220.24
114_I119_R0.5170.23
97_K138_A0.5160.23
55_D155_R0.5150.23
58_K162_P0.5130.23
80_K137_A0.5110.23
4_T79_L0.5080.23
3_K80_K0.5050.23
54_L109_A0.5000.22
19_L33_S0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bxoA 1 0.4054 11.3 0.965 Contact Map
3pzjA 2 0.3189 10 0.966 Contact Map
2z10A 2 0.3784 9.7 0.966 Contact Map
1yreA 2 0.3784 8.3 0.967 Contact Map
1wdkA 2 0.3243 7.7 0.968 Contact Map
4avaA 1 0.4324 5.4 0.97 Contact Map
1nslA 3 0.3135 4.4 0.971 Contact Map
1nltA 1 0.3027 4.3 0.972 Contact Map
2wtgA 2 0.3243 4.1 0.972 Contact Map
5bo7A 2 0.3135 4 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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