GREMLIN Database
Chorein_N - N-terminal region of Chorein or VPS13
PFAM: PF12624 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 116 (108)
Sequences: 2126 (1681)
Seq/√Len: 161.8
META: 0.492

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_G83_D6.4241.00
18_E40_E3.8781.00
37_E62_K3.1781.00
71_N75_E3.1601.00
62_K82_E3.0551.00
56_K89_E2.8171.00
33_D64_T2.5161.00
35_E62_K2.4231.00
35_E64_T2.2391.00
66_K78_V2.2161.00
33_D66_K2.1921.00
104_K108_A2.0721.00
54_E89_E2.0641.00
60_I84_V2.0161.00
71_N74_S1.9851.00
21_D24_Q1.6931.00
55_V88_L1.5021.00
18_E42_K1.4991.00
39_L58_G1.4621.00
105_R109_A1.4571.00
106_E109_A1.4251.00
30_W69_W1.4231.00
40_E57_S1.3701.00
17_V39_L1.3631.00
64_T80_E1.3321.00
15_K48_E1.2971.00
8_L12_Y1.2941.00
65_L79_V1.2591.00
103_E107_Q1.2341.00
66_K80_E1.1901.00
6_A10_N1.1691.00
101_E105_R1.1661.00
43_P47_D1.1631.00
30_W70_S1.1561.00
32_G69_W1.1381.00
61_G85_Y1.1201.00
45_A55_V1.0911.00
56_K87_L1.0901.00
103_E108_A1.0580.99
100_E104_K1.0470.99
40_E59_F1.0380.99
46_L55_V1.0260.99
104_K107_Q1.0240.99
17_V60_I1.0100.99
36_L39_L1.0050.99
18_E43_P0.9980.99
56_K59_F0.9950.99
54_E91_K0.9950.99
105_R108_A0.9910.99
5_V77_V0.9860.99
72_L77_V0.9800.99
6_A22_K0.9780.99
61_G82_E0.9710.99
75_E78_V0.9690.99
47_D55_V0.9570.99
66_K75_E0.9560.99
102_E106_E0.9520.99
58_G86_L0.9510.99
34_V65_L0.9390.99
2_E26_K0.9370.99
23_D93_D0.9250.98
96_K99_E0.9070.98
5_V12_Y0.8890.98
69_W77_V0.8830.98
67_I72_L0.8640.97
26_K45_A0.8610.97
16_Y19_N0.8600.97
10_N22_K0.8500.97
99_E103_E0.8430.97
24_Q38_N0.8430.97
38_N61_G0.8290.97
98_D101_E0.8210.97
95_E98_D0.8200.97
7_S11_R0.8110.96
18_E53_F0.8080.96
28_S31_S0.8050.96
17_V41_L0.8040.96
14_G25_L0.8040.96
46_L49_L0.8020.96
9_L12_Y0.8000.96
103_E106_E0.7990.96
3_S7_S0.7980.96
28_S67_I0.7960.96
43_P57_S0.7860.96
13_L36_L0.7820.95
101_E107_Q0.7790.95
44_D47_D0.7690.95
57_S87_L0.7670.95
38_N59_F0.7630.95
8_L11_R0.7550.95
15_K86_L0.7540.94
12_Y15_K0.7410.94
29_L34_V0.7380.94
53_F88_L0.7360.94
25_L34_V0.7260.93
47_D91_K0.7250.93
98_D102_E0.7190.93
7_S16_Y0.7080.92
7_S10_N0.6960.92
91_K94_S0.6890.91
47_D53_F0.6760.91
39_L60_I0.6730.90
15_K44_D0.6710.90
10_N30_W0.6690.90
20_L39_L0.6680.90
99_E109_A0.6650.90
36_L40_E0.6650.90
97_Y100_E0.6640.90
2_E22_K0.6590.89
51_L88_L0.6570.89
39_L63_L0.6400.88
43_P54_E0.6380.88
82_E85_Y0.6340.88
8_L17_V0.6310.87
100_E108_A0.6290.87
5_V30_W0.6250.87
94_S98_D0.6230.87
98_D103_E0.6200.86
103_E109_A0.6160.86
5_V13_L0.6160.86
81_I85_Y0.6090.85
96_K100_E0.6090.85
4_L11_R0.6070.85
102_E108_A0.6060.85
3_S40_E0.6030.85
28_S32_G0.6010.85
69_W72_L0.6000.85
12_Y65_L0.5990.85
4_L7_S0.5990.85
68_P75_E0.5950.84
41_L64_T0.5900.84
14_G20_L0.5840.83
60_I63_L0.5830.83
81_I84_V0.5800.83
96_K102_E0.5790.83
30_W77_V0.5780.82
81_I107_Q0.5770.82
42_K58_G0.5770.82
13_L24_Q0.5660.81
63_L81_I0.5630.81
3_S22_K0.5580.80
27_V34_V0.5570.80
101_E104_K0.5500.79
73_G77_V0.5490.79
94_S97_Y0.5480.79
68_P71_N0.5340.77
28_S34_V0.5310.77
15_K65_L0.5260.76
26_K34_V0.5200.75
30_W33_D0.5190.75
102_E105_R0.5170.75
5_V26_K0.5170.75
25_L33_D0.5170.75
29_L73_G0.5170.75
41_L54_E0.5150.75
9_L14_G0.5110.74
49_L52_P0.5100.74
35_E78_V0.5070.74
11_R22_K0.5050.73
17_V20_L0.5040.73
20_L24_Q0.5020.73
7_S73_G0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tqmA 1 0.6724 4.1 0.914 Contact Map
4bpeC 1 0.8621 3.8 0.915 Contact Map
1fcqA 1 0.1638 3.1 0.919 Contact Map
4ddpA 1 0.681 2.9 0.92 Contact Map
4d2uA 3 0.3362 2.8 0.92 Contact Map
4heiA 1 0.6638 2.8 0.92 Contact Map
4lkbF 4 0.3879 2.5 0.923 Contact Map
3v26X 1 0.681 2.1 0.925 Contact Map
2jn4A 1 0.4741 2.1 0.925 Contact Map
3bsoA 1 0.1724 2.1 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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