GREMLIN Database
PHM7_ext - Extracellular tail, of 10TM putative phosphate transporter
PFAM: PF12621 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 93 (92)
Sequences: 690 (486)
Seq/√Len: 50.7
META: 0.313

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_S74_D4.2241.00
77_A85_V2.9591.00
9_D12_T2.7561.00
53_R60_R2.6101.00
80_D86_V2.5981.00
80_D84_K2.3571.00
53_R74_D2.2341.00
63_V72_I2.2171.00
35_N38_L2.2091.00
66_T72_I2.1721.00
53_R59_S2.1721.00
76_G89_G2.1571.00
60_R74_D2.1461.00
51_I72_I1.8070.99
79_L86_V1.6750.98
30_E34_R1.6180.98
48_L73_T1.5910.98
60_R63_V1.5680.97
3_H6_I1.5550.97
51_I66_T1.5010.97
1_F9_D1.4940.97
52_P76_G1.4720.96
79_L85_V1.4400.96
88_D91_P1.3870.95
29_T32_L1.3850.95
62_E66_T1.3740.95
10_Y14_R1.3670.94
49_L70_I1.3540.94
61_Q65_H1.2970.93
6_I12_T1.2830.92
69_V72_I1.2360.91
57_G75_E1.1880.89
37_Y44_S1.1810.89
89_G92_P1.1580.88
2_L7_Y1.1350.87
56_L79_L1.1270.86
41_A62_E1.0840.84
51_I62_E1.0830.84
4_P7_Y1.0670.83
59_S63_V1.0510.82
61_Q64_A1.0280.81
8_A12_T1.0140.80
2_L68_K1.0090.79
58_V65_H1.0070.79
2_L13_L0.9790.77
29_T46_T0.9770.77
6_I23_D0.9630.76
20_D24_E0.9550.76
5_H39_H0.9450.75
1_F8_A0.9420.75
6_I9_D0.9230.73
72_I83_G0.9140.72
12_T83_G0.8790.69
62_E65_H0.8750.69
37_Y79_L0.8550.67
37_Y47_P0.8540.67
55_P81_E0.8510.67
39_H77_A0.8470.66
7_Y17_V0.8450.66
41_A57_G0.8410.66
1_F16_L0.8320.65
22_A88_D0.8300.65
79_L83_G0.8080.63
51_I70_I0.8010.62
4_P14_R0.8010.62
28_Y74_D0.7900.61
33_E38_L0.7830.60
23_D27_E0.7800.60
37_Y40_P0.7760.60
6_I21_Y0.7750.59
61_Q66_T0.7710.59
64_A83_G0.7650.59
20_D23_D0.7570.58
6_I22_A0.7570.58
12_T15_R0.7520.57
20_D88_D0.7500.57
3_H7_Y0.7460.57
29_T42_V0.7290.55
10_Y18_P0.7270.55
45_K83_G0.7250.54
51_I61_Q0.7240.54
18_P55_P0.7210.54
1_F11_A0.7160.54
44_S47_P0.7100.53
58_V84_K0.7090.53
39_H42_V0.7090.53
77_A87_W0.7010.52
18_P25_T0.6970.52
78_T86_V0.6960.51
7_Y61_Q0.6800.50
18_P28_Y0.6770.50
82_K86_V0.6670.48
31_E35_N0.6610.48
58_V70_I0.6460.46
71_P75_E0.6420.46
5_H8_A0.6410.46
8_A79_L0.6370.45
78_T83_G0.6360.45
60_R64_A0.6350.45
76_G90_R0.6340.45
41_A59_S0.6230.44
23_D71_P0.6220.44
16_L20_D0.6200.44
21_Y24_E0.6070.42
53_R88_D0.6060.42
3_H41_A0.5930.41
35_N48_L0.5900.41
36_A44_S0.5900.41
87_W90_R0.5890.41
31_E84_K0.5850.40
27_E55_P0.5850.40
1_F48_L0.5770.39
3_H9_D0.5750.39
64_A81_E0.5750.39
54_D57_G0.5730.39
41_A86_V0.5690.39
49_L71_P0.5680.38
3_H39_H0.5680.38
62_E72_I0.5620.38
19_D45_K0.5600.38
45_K86_V0.5550.37
7_Y10_Y0.5480.37
1_F6_I0.5430.36
25_T28_Y0.5430.36
10_Y13_L0.5400.36
48_L84_K0.5390.36
5_H41_A0.5380.36
1_F12_T0.5370.35
28_Y59_S0.5340.35
78_T85_V0.5240.34
78_T88_D0.5190.34
39_H51_I0.5190.34
3_H45_K0.5130.33
30_E33_E0.5110.33
9_D52_P0.5060.33
34_R47_P0.5050.33
22_A31_E0.5040.32
42_V85_V0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yorA 2 0.8172 10.1 0.915 Contact Map
4h3wA 1 0.871 6.9 0.921 Contact Map
4x9rA 1 0.7849 6.5 0.922 Contact Map
1ao0A 3 0.9892 6.5 0.922 Contact Map
3kj0B 1 0.2581 6.4 0.922 Contact Map
4tmaI 1 0.5269 6.4 0.922 Contact Map
2ciwA 1 0.7957 6.2 0.922 Contact Map
1jgtA 2 0.957 5.7 0.924 Contact Map
4dloA 1 0.3118 5.6 0.924 Contact Map
2ycuA 1 0.5591 5.6 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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