GREMLIN Database
DUF3775 - Protein of unknown function (DUF3775)
PFAM: PF12616 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 73 (71)
Sequences: 4747 (2630)
Seq/√Len: 312.1
META: 0.936

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_M57_M4.1911.00
30_Y38_A3.3821.00
18_E39_R3.1751.00
59_L63_Y2.1921.00
41_E44_E1.8801.00
8_I16_Q1.8591.00
24_W53_Y1.7231.00
41_E45_E1.7141.00
17_A43_R1.7021.00
32_A71_L1.6961.00
40_A44_E1.6621.00
4_L8_I1.6341.00
6_A10_D1.5911.00
25_L38_A1.5741.00
22_L67_G1.5661.00
9_D51_A1.5311.00
39_R43_R1.4261.00
5_R52_D1.4141.00
16_Q46_H1.4081.00
12_N15_E1.3491.00
32_A70_A1.3061.00
18_E35_W1.2601.00
5_R55_L1.2501.00
37_E41_E1.2491.00
30_Y41_E1.2321.00
4_L55_L1.2081.00
66_E70_A1.1901.00
57_M63_Y1.1501.00
15_E18_E1.1291.00
16_Q50_T1.0951.00
29_D45_E1.0811.00
66_E69_A1.0671.00
27_R53_Y1.0661.00
46_H49_R1.0631.00
22_L71_L1.0621.00
20_V50_T1.0601.00
28_G70_A1.0241.00
25_L70_A1.0161.00
31_D34_E1.0091.00
36_D40_A0.9931.00
13_E17_A0.9711.00
5_R9_D0.9691.00
7_F15_E0.8881.00
8_I19_L0.8811.00
60_L64_L0.8661.00
21_A42_A0.8621.00
2_E6_A0.8611.00
54_L60_L0.8471.00
17_A46_H0.8451.00
30_Y34_E0.8321.00
23_M54_L0.8251.00
4_L60_L0.8231.00
23_M60_L0.8211.00
10_D16_Q0.8091.00
25_L32_A0.7981.00
8_I51_A0.7931.00
35_W39_R0.7791.00
47_N50_T0.7690.99
46_H50_T0.7630.99
48_E52_D0.7560.99
3_E58_P0.7520.99
2_E7_F0.7300.99
9_D52_D0.7200.99
20_V53_Y0.7170.99
16_Q19_L0.7150.99
31_D70_A0.7100.99
67_G70_A0.7030.99
45_E50_T0.6980.99
46_H51_A0.6880.99
65_E69_A0.6840.99
21_A25_L0.6740.99
2_E5_R0.6690.99
27_R63_Y0.6630.98
4_L7_F0.6560.98
33_E36_D0.6410.98
36_D43_R0.6410.98
6_A9_D0.6370.98
17_A39_R0.6240.98
28_G31_D0.6190.98
23_M63_Y0.6180.98
61_A65_E0.6150.97
63_Y66_E0.6080.97
7_F10_D0.6060.97
25_L71_L0.6020.97
62_D66_E0.5930.97
66_E72_G0.5930.97
3_E7_F0.5840.97
2_E9_D0.5790.96
34_E37_E0.5780.96
35_W71_L0.5730.96
26_G67_G0.5700.96
20_V24_W0.5690.96
22_L68_L0.5660.96
25_L30_Y0.5570.95
61_A66_E0.5570.95
24_W42_A0.5480.95
32_A36_D0.5440.95
12_N18_E0.5410.95
28_G66_E0.5330.94
13_E16_Q0.5320.94
24_W27_R0.5200.93
9_D12_N0.5140.93
24_W45_E0.5130.93
28_G38_A0.5110.93
16_Q52_D0.5000.92
17_A47_N0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xgcD 1 0.9863 29.6 0.833 Contact Map
2qbyA 1 0.9041 22.9 0.842 Contact Map
2sasA 2 0.8082 9.7 0.866 Contact Map
2marA 1 0.3973 9.6 0.867 Contact Map
1fnnA 1 0.9726 9.2 0.867 Contact Map
4yfkF 1 0.9041 7.8 0.871 Contact Map
1w5sA 1 0.9863 7.5 0.873 Contact Map
4elnA 1 0.8219 7.3 0.874 Contact Map
3n0rA 1 0.9589 7 0.875 Contact Map
2v1uA 1 0.9589 5.5 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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