GREMLIN Database
DUF3774 - Wound-induced protein
PFAM: PF12609 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (75)
Sequences: 516 (384)
Seq/√Len: 44.3
META: 0.101

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_L30_A3.0831.00
65_R71_S2.6701.00
71_S75_P2.5291.00
65_R69_Y2.3471.00
60_S69_Y2.0290.99
16_L22_A1.9200.99
67_V71_S1.7660.98
40_A44_S1.7590.98
63_S69_Y1.6220.97
18_R21_Y1.5720.96
6_G11_L1.5350.96
63_S68_M1.5120.95
62_E65_R1.4920.95
64_L69_Y1.4780.95
68_M71_S1.4780.95
13_D24_R1.4130.93
60_S63_S1.4080.93
53_R57_A1.3640.92
19_W27_H1.3450.91
66_T71_S1.3270.91
63_S71_S1.3220.91
21_Y24_R1.3150.90
54_D57_A1.2760.89
59_Q65_R1.2540.88
14_Q24_R1.2500.88
46_S57_A1.2260.87
16_L26_L1.2160.87
64_L72_C1.2150.87
3_A6_G1.2080.86
59_Q69_Y1.2010.86
61_E75_P1.1950.86
12_K75_P1.1760.85
17_C22_A1.1640.84
2_A5_V1.1270.82
62_E73_W1.0680.79
39_Q42_K1.0600.78
7_A59_Q1.0440.77
32_N48_S1.0400.77
35_R44_S1.0340.76
21_Y27_H1.0330.76
6_G65_R1.0310.76
8_V15_G1.0290.76
11_L17_C1.0120.75
11_L30_A0.9990.74
63_S72_C0.9990.74
28_Q32_N0.9710.72
55_E60_S0.9640.71
15_G19_W0.9620.71
9_E18_R0.9390.69
26_L33_N0.9350.69
3_A63_S0.9340.69
35_R48_S0.9240.68
5_V26_L0.9150.67
10_A27_H0.9120.67
64_L71_S0.8820.64
60_S65_R0.8500.61
33_N72_C0.8460.61
3_A66_T0.8330.60
57_A64_L0.8270.59
23_L28_Q0.8240.59
20_N67_V0.8110.58
4_S9_E0.8040.57
68_M72_C0.7970.56
36_S39_Q0.7950.56
9_E12_K0.7930.56
19_W23_L0.7900.56
45_S50_S0.7790.55
7_A43_L0.7730.54
3_A54_D0.7710.54
1_V10_A0.7640.53
14_Q25_S0.7510.52
6_G33_N0.7480.52
23_L55_E0.7440.51
34_V38_S0.7320.50
10_A19_W0.7300.50
37_L40_A0.7300.50
35_R38_S0.7280.50
30_A75_P0.7260.49
7_A12_K0.7070.48
35_R45_S0.7040.47
7_A33_N0.6780.45
1_V12_K0.6780.45
69_Y73_W0.6730.44
5_V16_L0.6660.44
54_D66_T0.6600.43
13_D18_R0.6550.43
36_S67_V0.6530.42
53_R58_K0.6520.42
6_G9_E0.6500.42
20_N24_R0.6470.42
30_A56_K0.6390.41
61_E68_M0.6360.41
55_E59_Q0.6180.39
6_G17_C0.6160.39
27_H55_E0.6120.39
10_A32_N0.6120.39
65_R73_W0.5960.37
3_A72_C0.5910.37
60_S66_T0.5880.36
62_E69_Y0.5750.35
7_A72_C0.5740.35
61_E67_V0.5720.35
4_S27_H0.5710.35
20_N75_P0.5440.33
11_L75_P0.5420.32
29_H33_N0.5400.32
61_E66_T0.5390.32
9_E19_W0.5370.32
1_V75_P0.5360.32
13_D21_Y0.5100.30
52_A62_E0.5010.29
5_V20_N0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ki9A 1 0.2533 4.4 0.919 Contact Map
4phuA 1 0.96 2.3 0.93 Contact Map
3wv7A 3 0.2267 2.2 0.931 Contact Map
4s28A 2 0.8667 2 0.933 Contact Map
4s0vA 1 0.9467 1.9 0.933 Contact Map
3epoA 2 0.8 1.8 0.934 Contact Map
3tacB 1 0.3467 1.7 0.935 Contact Map
2r4rA 1 0.6133 1.6 0.936 Contact Map
4xesA 1 0.48 1.5 0.937 Contact Map
4m3pA 4 0.76 1.5 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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