GREMLIN Database
DUF3772 - Protein of unknown function (DUF3772)
PFAM: PF12607 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 61 (58)
Sequences: 3303 (2395)
Seq/√Len: 314.5
META: 0.858

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_L23_R2.6551.00
3_R7_V2.1851.00
7_V11_Q2.0781.00
42_R46_A2.0651.00
4_L11_Q2.0511.00
37_S40_F1.8491.00
49_P52_L1.8371.00
25_T29_L1.8081.00
10_D14_A1.7831.00
18_A22_A1.7471.00
20_R24_F1.6891.00
8_R12_L1.6861.00
56_G59_V1.6141.00
51_D54_R1.5561.00
31_R34_S1.5261.00
20_R23_R1.5061.00
52_L56_G1.4511.00
53_R56_G1.4181.00
13_I35_P1.3821.00
6_A10_D1.3511.00
38_P42_R1.2181.00
13_I17_D1.1861.00
50_D54_R1.1811.00
27_R30_E1.1451.00
43_D46_A1.1331.00
17_D38_P1.1091.00
33_P40_F1.1041.00
10_D17_D1.0451.00
12_L15_R1.0371.00
11_Q15_R1.0291.00
38_P45_A1.0211.00
53_R57_A0.9991.00
2_A55_L0.9781.00
11_Q26_R0.9501.00
47_A51_D0.9471.00
12_L57_A0.9331.00
23_R27_R0.8951.00
32_S40_F0.8861.00
24_F27_R0.8831.00
4_L15_R0.8731.00
9_A12_L0.8701.00
8_R51_D0.8681.00
43_D47_A0.8541.00
11_Q28_L0.8471.00
34_S44_A0.8321.00
6_A14_A0.8161.00
18_A31_R0.8061.00
5_L11_Q0.7841.00
23_R29_L0.7831.00
19_L22_A0.7811.00
54_R57_A0.7660.99
33_P37_S0.7650.99
5_L12_L0.7650.99
3_R6_A0.7580.99
9_A13_I0.7380.99
15_R35_P0.7280.99
40_F43_D0.7160.99
26_R31_R0.7090.99
16_I38_P0.6830.99
21_R24_F0.6710.99
49_P53_R0.6620.98
33_P43_D0.6610.98
50_D53_R0.6500.98
12_L48_L0.6480.98
13_I59_V0.6350.98
3_R26_R0.6300.98
4_L30_E0.6240.98
29_L51_D0.6210.98
13_I32_S0.6160.98
48_L52_L0.6140.97
55_L59_V0.6110.97
50_D56_G0.6110.97
23_R30_E0.5950.97
4_L18_A0.5780.96
5_L39_A0.5710.96
40_F58_L0.5650.96
49_P54_R0.5500.95
31_R36_L0.5470.95
46_A49_P0.5450.95
47_A53_R0.5440.95
44_A47_A0.5280.94
36_L42_R0.5180.93
4_L31_R0.5180.93
16_I20_R0.5150.93
8_R25_T0.5060.93
45_A49_P0.5040.93
52_L59_V0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wh1A 1 0.7705 4.3 0.848 Contact Map
4wmuA 1 0.9672 4 0.851 Contact Map
3g13A 2 0.5246 3.1 0.858 Contact Map
2v0oA 2 0.4918 2.8 0.862 Contact Map
3fs3A 2 0.9836 2.8 0.862 Contact Map
2zd7A 2 0.9016 2.6 0.864 Contact Map
2b82A 4 0.4918 2.2 0.869 Contact Map
3l39A 3 0.9836 2.1 0.871 Contact Map
3cuqA 1 0.8361 2.1 0.871 Contact Map
1hz4A 2 0.2787 2 0.871 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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