GREMLIN Database
DUF3768 - Protein of unknown function (DUF3768)
PFAM: PF12599 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (83)
Sequences: 5267 (3717)
Seq/√Len: 408.0
META: 0.949

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_G50_W2.6981.00
56_D61_Y2.4701.00
18_A22_T2.2131.00
59_L73_T2.1701.00
64_P71_V2.0781.00
40_S47_K2.0621.00
4_G83_E2.0501.00
9_G12_A2.0221.00
6_A13_V1.7881.00
16_I43_V1.7781.00
9_G13_V1.7781.00
19_A43_V1.7621.00
15_R44_D1.7471.00
40_S49_F1.7401.00
56_D60_E1.7271.00
31_D36_H1.7221.00
12_A16_I1.7181.00
5_V48_I1.6941.00
48_I80_L1.6921.00
68_D71_V1.6901.00
38_F49_F1.6331.00
57_R73_T1.5921.00
18_A21_R1.5681.00
42_E47_K1.5511.00
12_A43_V1.5081.00
63_S72_T1.4671.00
16_I48_I1.4341.00
62_G66_P1.4311.00
8_L12_A1.4091.00
41_F48_I1.3121.00
20_V78_I1.3041.00
12_A44_D1.2861.00
17_L21_R1.2761.00
63_S71_V1.2721.00
1_M6_A1.2561.00
15_R19_A1.2511.00
3_A7_A1.2231.00
10_P13_V1.1901.00
35_E54_Y1.1841.00
49_F79_M1.1621.00
8_L46_E1.0811.00
46_E82_E1.0561.00
57_R64_P1.0111.00
19_A41_F1.0061.00
10_P14_A1.0051.00
3_A6_A0.9981.00
28_E34_G0.9931.00
4_G80_L0.9461.00
49_F81_A0.9181.00
54_Y72_T0.9161.00
14_A17_L0.8771.00
20_V41_F0.8731.00
16_I20_V0.8531.00
58_D61_Y0.8481.00
27_T30_N0.8471.00
47_K81_A0.8441.00
13_V17_L0.8431.00
16_I78_I0.8281.00
15_R18_A0.8241.00
23_F26_F0.8041.00
5_V16_I0.8021.00
20_V76_L0.7971.00
65_D71_V0.7611.00
42_E45_G0.7571.00
23_F41_F0.7561.00
46_E80_L0.7561.00
52_I76_L0.7541.00
14_A18_A0.7531.00
39_G76_L0.7521.00
12_A48_I0.7381.00
12_A15_R0.7321.00
6_A10_P0.7261.00
6_A9_G0.7241.00
30_N38_F0.7191.00
14_A21_R0.7101.00
15_R43_V0.6871.00
68_D72_T0.6760.99
80_L83_E0.6660.99
16_I41_F0.6630.99
19_A22_T0.6600.99
11_E14_A0.6530.99
63_S67_A0.6530.99
5_V8_L0.6510.99
62_G73_T0.6500.99
4_G48_I0.6420.99
23_F30_N0.6420.99
56_D59_L0.6390.99
12_A46_E0.6310.99
19_A25_D0.6280.99
9_G16_I0.6270.99
17_L78_I0.6170.99
43_V48_I0.6140.99
66_P72_T0.6070.99
56_D63_S0.6050.99
39_G49_F0.6050.99
63_S66_P0.5960.99
54_Y67_A0.5930.99
33_H37_D0.5900.99
43_V50_W0.5840.99
5_V20_V0.5740.98
63_S68_D0.5630.98
27_T33_H0.5590.98
54_Y62_G0.5560.98
1_M17_L0.5560.98
54_Y65_D0.5540.98
54_Y59_L0.5540.98
57_R71_V0.5500.98
67_A72_T0.5450.98
50_W76_L0.5440.98
5_V13_V0.5390.98
9_G48_I0.5350.97
53_D77_T0.5350.97
30_N40_S0.5340.97
57_R61_Y0.5190.97
10_P18_A0.5180.97
4_G7_A0.5170.97
33_H38_F0.5120.97
64_P67_A0.5110.97
23_F27_T0.5100.97
11_E15_R0.5090.97
11_E18_A0.5070.96
37_D54_Y0.5060.96
37_D51_K0.5020.96
7_A11_E0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r41A 5 0.9277 14.5 0.91 Contact Map
2jnsA 1 0.7711 11 0.915 Contact Map
1bm4A 1 0.3133 8.8 0.919 Contact Map
1i4oC 1 0 6.4 0.924 Contact Map
3sxuB 1 0.3373 5.4 0.926 Contact Map
2hr3A 2 0.3735 4.8 0.928 Contact Map
4l9nA 2 0.3494 4.4 0.929 Contact Map
4pqxA 2 0.5904 4.3 0.93 Contact Map
3op9A 4 0.3494 4.1 0.93 Contact Map
2q5xA 1 0.7349 3.9 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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