GREMLIN Database
WBS_methylT - Methyltransferase involved in Williams-Beuren syndrome
PFAM: PF12589 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 82 (79)
Sequences: 600 (473)
Seq/√Len: 53.2
META: 0.307

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_R65_Q6.1351.00
55_I77_G4.9141.00
63_R72_D3.4561.00
3_A7_G2.4651.00
62_R65_Q2.2371.00
62_R70_R2.1861.00
50_K54_W1.8260.99
56_L72_D1.6830.99
57_K61_R1.6730.99
32_E35_R1.6300.98
57_K62_R1.4710.97
1_L4_G1.4460.96
46_K49_K1.4370.96
57_K65_Q1.4250.96
11_L14_G1.4240.96
61_R70_R1.3760.95
34_R41_R1.3690.95
2_F7_G1.3460.95
61_R67_K1.3400.95
31_F35_R1.2950.93
45_K49_K1.2470.92
55_I74_K1.2310.92
47_K51_S1.2310.92
15_L57_K1.1840.90
59_K63_R1.1660.89
59_K76_T1.1630.89
56_L70_R1.1250.88
7_G10_Q1.1060.87
14_G17_G1.1060.87
16_G53_E1.0970.86
70_R73_S1.0870.86
56_L73_S1.0840.85
59_K72_D1.0460.83
14_G60_E1.0400.83
52_R56_L1.0240.82
31_F34_R1.0230.82
51_S54_W0.9910.80
33_D76_T0.9910.80
42_K47_K0.9880.80
34_R38_R0.9780.79
51_S64_R0.9700.78
16_G19_E0.9680.78
42_K45_K0.9460.77
62_R69_V0.9330.76
3_A9_Q0.9320.76
8_S33_D0.9220.75
9_Q18_E0.8880.72
38_R52_R0.8870.72
33_D36_R0.8860.72
65_Q70_R0.8730.71
60_E67_K0.8530.69
76_T80_R0.8420.68
77_G80_R0.8210.66
13_K16_G0.8080.65
12_P15_L0.7990.64
37_R40_K0.7840.62
56_L76_T0.7670.61
32_E39_K0.7650.60
75_Y78_R0.7460.59
38_R41_R0.7430.58
14_G71_P0.7420.58
34_R37_R0.7410.58
62_R75_Y0.7390.58
75_Y80_R0.7380.58
56_L63_R0.7370.58
13_K35_R0.7330.57
27_E36_R0.7320.57
38_R46_K0.7290.57
43_G46_K0.7270.57
9_Q19_E0.7220.56
2_F14_G0.7210.56
51_S77_G0.7140.55
16_G21_E0.7130.55
11_L15_L0.7130.55
33_D40_K0.7060.54
29_V64_R0.6990.54
12_P16_G0.6920.53
51_S57_K0.6880.52
45_K79_K0.6870.52
2_F10_Q0.6870.52
36_R39_K0.6830.52
48_G73_S0.6830.52
13_K53_E0.6820.52
19_E25_E0.6790.52
60_E64_R0.6750.51
40_K50_K0.6720.51
71_P75_Y0.6580.49
30_R33_D0.6470.48
18_E22_E0.6430.48
45_K52_R0.6360.47
10_Q74_K0.6210.45
31_F42_K0.6190.45
51_S61_R0.6070.44
47_K81_K0.6060.44
16_G20_E0.6060.44
39_K56_L0.6030.44
75_Y81_K0.6010.43
12_P72_D0.5970.43
53_E77_G0.5940.43
2_F74_K0.5790.41
3_A74_K0.5740.41
31_F39_K0.5720.40
37_R70_R0.5720.40
58_K63_R0.5700.40
64_R68_E0.5620.39
21_E53_E0.5580.39
10_Q57_K0.5530.38
17_G20_E0.5520.38
48_G53_E0.5450.38
38_R65_Q0.5390.37
50_K75_Y0.5390.37
26_M29_V0.5340.37
45_K55_I0.5330.36
51_S70_R0.5300.36
38_R68_E0.5200.35
64_R75_Y0.5190.35
11_L28_T0.5020.33
10_Q42_K0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uwpA 1 0 62 0.846 Contact Map
4cidA 2 0.2927 2.2 0.927 Contact Map
4qitA 2 0.3293 2 0.929 Contact Map
4hsuA 1 0.3902 1.7 0.931 Contact Map
3k7mX 2 0.3902 1.6 0.932 Contact Map
1g60A 2 0.4634 1.5 0.933 Contact Map
1rsgA 2 0.4756 1.4 0.934 Contact Map
5a1uC 1 0 1.3 0.935 Contact Map
4akfA 2 0.1341 1.2 0.936 Contact Map
4aajA 1 0.6098 1.2 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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