GREMLIN Database
PSDC - Phophatidylserine decarboxylase
PFAM: PF12588 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 140 (134)
Sequences: 1159 (820)
Seq/√Len: 70.8
META: 0.677

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_E106_K4.4511.00
27_Q90_A3.7031.00
21_F94_A3.5301.00
4_V54_L3.1691.00
54_L107_I2.6161.00
5_Q9_D2.6121.00
54_L78_I2.4401.00
44_V53_L2.3321.00
85_P95_F2.3091.00
23_Q27_Q2.0721.00
61_A123_V2.0301.00
10_L103_Q1.9791.00
10_L17_L1.9251.00
11_I17_L1.9111.00
114_F122_Y1.8741.00
3_V103_Q1.8431.00
112_G116_S1.8201.00
14_D99_K1.7881.00
103_Q106_K1.7581.00
3_V110_A1.7441.00
5_Q8_K1.7321.00
25_F47_Y1.7241.00
11_I51_L1.7001.00
7_F103_Q1.6781.00
3_V6_E1.6691.00
134_P138_K1.6130.99
46_D49_H1.5950.99
121_R132_F1.5540.99
28_V34_Y1.5530.99
94_A100_V1.4980.99
11_I47_Y1.4210.98
110_A113_E1.4150.98
21_F100_V1.4060.98
32_P35_N1.3360.98
105_K109_N1.3290.98
20_L94_A1.2960.97
63_E129_T1.2920.97
50_M54_L1.2760.97
25_F85_P1.2690.97
22_T26_E1.2580.97
82_L104_L1.2450.96
2_P6_E1.2260.96
76_F79_N1.2190.96
73_L76_F1.1990.96
16_V97_D1.1940.95
45_R49_H1.1910.95
38_P43_Q1.1710.95
50_M81_I1.1490.94
9_D13_S1.1410.94
74_V80_A1.1360.94
125_N129_T1.1320.94
72_G76_F1.1250.94
3_V106_K1.1200.94
3_V7_F1.1170.93
4_V7_F1.1140.93
31_K35_N1.1130.93
79_N83_D1.0600.92
119_D122_Y1.0570.91
54_L104_L1.0460.91
23_Q90_A1.0400.91
10_L102_A1.0310.90
73_L79_N1.0260.90
102_A105_K1.0170.90
7_F100_V1.0130.90
124_L132_F1.0110.90
118_P121_R1.0000.89
58_L78_I0.9830.88
30_R35_N0.9820.88
76_F86_M0.9750.88
20_L90_A0.9700.88
53_L81_I0.9670.87
80_A83_D0.9660.87
128_P135_A0.9660.87
17_L100_V0.9640.87
61_A122_Y0.9630.87
125_N130_G0.9570.87
6_E103_Q0.9560.87
16_V20_L0.9550.87
84_W87_G0.9460.86
109_N112_G0.9430.86
79_N86_M0.9420.86
19_M93_A0.9390.86
15_P19_M0.9360.86
8_K47_Y0.9290.85
72_G83_D0.9050.84
6_E9_D0.9020.83
12_E47_Y0.8990.83
29_P34_Y0.8830.82
75_G95_F0.8820.82
4_V55_N0.8720.81
8_K48_D0.8670.81
57_I81_I0.8620.81
30_R33_P0.8460.79
51_L104_L0.8410.79
129_T133_S0.8400.79
37_D85_P0.8320.78
31_K34_Y0.8250.78
64_F135_A0.8250.78
70_E139_A0.8180.77
18_R22_T0.8130.77
128_P139_A0.7980.75
34_Y37_D0.7820.74
72_G75_G0.7780.73
115_L120_S0.7700.73
28_V35_N0.7660.72
58_L110_A0.7630.72
82_L85_P0.7620.72
24_M88_T0.7610.72
8_K51_L0.7570.71
88_T111_W0.7450.70
73_L83_D0.7380.69
126_D132_F0.7340.69
49_H52_R0.7320.69
20_L93_A0.7310.69
34_Y38_P0.7300.68
125_N128_P0.7300.68
63_E122_Y0.7290.68
11_I50_M0.7290.68
135_A138_K0.7270.68
126_D137_L0.7270.68
23_Q26_E0.7270.68
8_K12_E0.7220.68
25_F50_M0.7150.67
80_A87_G0.7120.67
126_D138_K0.7110.66
53_L56_H0.7100.66
79_N85_P0.7070.66
126_D134_P0.6920.64
133_S137_L0.6870.64
20_L108_L0.6830.63
45_R127_S0.6830.63
71_T74_V0.6750.62
99_K102_A0.6750.62
88_T101_N0.6740.62
111_W115_L0.6730.62
76_F87_G0.6720.62
75_G79_N0.6640.61
30_R76_F0.6600.61
127_S133_S0.6580.60
54_L70_E0.6570.60
53_L84_W0.6530.60
27_Q89_P0.6480.59
15_P64_F0.6460.59
56_H60_T0.6440.59
71_T136_A0.6390.58
35_N89_P0.6380.58
64_F139_A0.6330.57
54_L82_L0.6320.57
18_R96_L0.6290.57
28_V42_P0.6290.57
104_L107_I0.6280.57
69_N75_G0.6240.56
12_E48_D0.6230.56
29_P94_A0.6210.56
54_L81_I0.6210.56
60_T63_E0.6190.56
16_V96_L0.6120.55
64_F71_T0.6050.54
73_L78_I0.6040.54
117_S120_S0.6030.54
132_F137_L0.6020.54
34_Y98_P0.5980.53
18_R25_F0.5970.53
133_S138_K0.5910.52
114_F126_D0.5870.52
71_T76_F0.5870.52
11_I21_F0.5840.52
71_T75_G0.5820.51
78_I83_D0.5800.51
69_N108_L0.5790.51
13_S126_D0.5790.51
9_D113_E0.5700.50
87_G92_F0.5700.50
2_P5_Q0.5650.49
49_H53_L0.5620.49
17_L94_A0.5580.48
24_M123_V0.5480.47
7_F106_K0.5420.46
74_V82_L0.5390.46
58_L73_L0.5390.46
74_V87_G0.5320.45
120_S131_W0.5290.45
46_D61_A0.5290.45
79_N84_W0.5280.45
55_N58_L0.5270.45
78_I100_V0.5250.44
48_D70_E0.5250.44
7_F24_M0.5250.44
24_M94_A0.5240.44
20_L23_Q0.5220.44
70_E135_A0.5210.44
126_D130_G0.5210.44
98_P118_P0.5200.44
38_P84_W0.5130.43
64_F70_E0.5120.43
7_F16_V0.5090.42
64_F136_A0.5090.42
117_S123_V0.5030.42
28_V43_Q0.5030.42
79_N95_F0.5030.42
3_V58_L0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cg9A 2 0.3929 72.1 0.914 Contact Map
2ioqA 2 0.3643 71.4 0.915 Contact Map
2cgeA 6 0.3929 71 0.915 Contact Map
2o1uA 2 0.4 69.7 0.916 Contact Map
1sf8A 5 0.3643 63.4 0.919 Contact Map
4ipeA 2 0.3857 62.4 0.92 Contact Map
4ivgA 4 0 58.4 0.922 Contact Map
3hjcA 5 0.3929 36.2 0.931 Contact Map
2qsfX 1 0.6643 32.7 0.933 Contact Map
4flbA 2 0.7071 31.7 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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