GREMLIN Database
DUF3761 - Protein of unknown function (DUF3761)
PFAM: PF12587 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 88 (78)
Sequences: 1057 (907)
Seq/√Len: 102.7
META: 0.904

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_N72_Q6.0991.00
40_D73_H4.1161.00
45_H48_A2.8651.00
62_Q86_R2.7321.00
61_A69_S2.6201.00
37_T43_T2.5061.00
35_Y43_T2.1541.00
55_A88_L1.8171.00
71_S77_T1.7131.00
39_S73_H1.7111.00
59_A68_Y1.6411.00
56_P68_Y1.6401.00
49_H67_T1.6331.00
34_G46_S1.6081.00
40_D72_Q1.5591.00
55_A70_F1.4341.00
18_K22_A1.3701.00
76_G79_S1.3420.99
32_N49_H1.2580.99
64_R85_A1.2460.99
78_C81_H1.2220.99
36_Y44_V1.2020.99
55_A68_Y1.1830.99
48_A70_F1.1290.98
38_N45_H1.1110.98
12_A19_A1.0990.98
27_E33_H1.0810.97
32_N48_A1.0700.97
71_S84_V1.0670.97
16_A20_A1.0410.97
31_S49_H1.0320.96
36_Y41_G1.0300.96
84_V87_W0.9910.96
37_T41_G0.9870.95
26_A33_H0.9790.95
31_S43_T0.9660.95
66_G77_T0.9620.95
30_L48_A0.9450.94
12_A22_A0.9310.94
69_S79_S0.9290.94
19_A29_D0.9220.93
35_Y45_H0.9200.93
78_C83_G0.9190.93
26_A29_D0.9180.93
56_P59_A0.9170.93
75_R79_S0.9110.93
36_Y47_P0.9060.93
71_S75_R0.9030.93
12_A16_A0.8970.93
73_H77_T0.8920.92
23_A26_A0.8800.92
41_G47_P0.8620.91
11_L16_A0.8590.91
16_A19_A0.8570.91
74_R87_W0.8420.90
52_S55_A0.8330.89
74_R88_L0.8240.89
25_P33_H0.8230.89
13_A20_A0.8170.89
69_S77_T0.7990.87
61_A77_T0.7940.87
61_A88_L0.7940.87
44_V47_P0.7930.87
50_S57_A0.7590.85
23_A28_A0.7580.85
38_N47_P0.7450.84
47_P56_P0.7440.83
34_G45_H0.7350.83
13_A16_A0.7260.82
50_S55_A0.7260.82
44_V72_Q0.6890.78
50_S53_G0.6870.78
22_A25_P0.6750.77
25_P30_L0.6710.77
56_P70_F0.6700.77
59_A70_F0.6670.76
58_G70_F0.6660.76
14_P19_A0.6630.76
46_S50_S0.6630.76
37_T74_R0.6570.75
29_D33_H0.6540.75
79_S82_G0.6520.75
64_R80_H0.6490.74
71_S76_G0.6370.73
36_Y77_T0.6350.73
60_T63_C0.6330.72
58_G68_Y0.6320.72
78_C82_G0.6230.71
76_G81_H0.6100.70
37_T45_H0.6010.69
74_R85_A0.5940.68
16_A21_A0.5900.67
12_A20_A0.5890.67
63_C66_G0.5890.67
13_A18_K0.5890.67
62_Q85_A0.5830.66
77_T87_W0.5790.66
81_H84_V0.5690.64
11_L21_A0.5680.64
77_T84_V0.5680.64
58_G86_R0.5660.64
64_R67_T0.5630.64
22_A26_A0.5580.63
18_K21_A0.5440.61
11_L23_A0.5390.60
41_G44_V0.5380.60
24_A28_A0.5370.60
14_P18_K0.5340.59
33_H45_H0.5330.59
77_T80_H0.5330.59
65_D81_H0.5310.59
62_Q66_G0.5200.57
30_L45_H0.5200.57
25_P29_D0.5190.57
57_A80_H0.5090.56
13_A17_A0.5060.55
35_Y46_S0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uz1A 1 0.375 9.4 0.902 Contact Map
4uzkA 2 0.3636 7.5 0.906 Contact Map
4ixjA 1 0.7955 3.5 0.92 Contact Map
2k1iA 1 0.3295 2.3 0.927 Contact Map
3qteA 2 0.3295 1.9 0.931 Contact Map
4rbxA 1 0.3295 1.8 0.931 Contact Map
4ei0A 2 0.9318 1.7 0.932 Contact Map
4m4pA 1 0.5795 1.5 0.935 Contact Map
1zmmA 1 0.3182 1.4 0.935 Contact Map
4wbhA 2 0.375 1.4 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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