GREMLIN Database
DUF3759 - Protein of unknown function (DUF3759)
PFAM: PF12585 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (88)
Sequences: 728 (556)
Seq/√Len: 59.3
META: 0.547

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_L54_F3.5831.00
25_F46_K3.1651.00
20_A24_A2.2971.00
33_D37_K2.1191.00
58_F62_L2.1161.00
81_K85_E1.9861.00
21_G53_G1.8451.00
24_A56_G1.7890.99
70_F74_E1.7750.99
12_A61_R1.7680.99
32_E49_E1.7270.99
30_A33_D1.7180.99
78_H81_K1.6630.99
75_K78_H1.6510.99
63_V68_L1.6320.99
35_Q40_K1.6290.99
84_A88_Y1.5970.99
62_L66_K1.5950.99
21_G24_A1.5950.99
31_Y35_Q1.5890.99
29_K33_D1.5840.99
26_E30_A1.5370.98
36_A42_V1.4180.97
35_Q42_V1.3960.97
74_E77_K1.3580.96
8_A14_L1.3220.96
74_E78_H1.3000.95
51_L84_A1.2890.95
79_H82_E1.2640.94
46_K49_E1.2640.94
78_H82_E1.2540.94
33_D36_A1.2420.94
79_H83_Q1.2030.93
63_V71_I1.1860.92
42_V46_K1.1780.92
8_A11_K1.1530.91
14_L18_L1.1380.91
10_H68_L1.1370.91
34_H54_F1.1210.90
21_G57_A1.1160.90
3_D7_N1.1030.89
2_Y6_Y1.1020.89
23_A58_F1.1010.89
32_E42_V1.0960.89
68_L71_I1.0830.88
58_F61_R1.0780.88
12_A17_E1.0760.88
84_A87_A1.0720.88
56_G60_D1.0200.85
86_E89_D0.9980.84
55_A88_Y0.9860.83
74_E81_K0.9780.83
30_A34_H0.9720.82
46_K50_L0.9700.82
23_A59_V0.9550.81
42_V45_A0.9470.81
20_A28_A0.9420.80
19_I26_E0.9150.78
20_A79_H0.9060.78
6_Y9_P0.9040.77
2_Y9_P0.8950.77
24_A27_A0.8850.76
82_E85_E0.8650.74
69_D72_D0.8640.74
5_V8_A0.8480.73
24_A28_A0.8390.72
36_A45_A0.8320.71
38_N41_P0.8090.69
42_V48_K0.8070.69
27_A63_V0.8070.69
85_E89_D0.8030.69
51_L83_Q0.8020.69
19_I29_K0.7940.68
60_D77_K0.7880.67
5_V62_L0.7800.66
76_A80_A0.7780.66
65_T69_D0.7710.66
4_Q8_A0.7680.65
81_K84_A0.7620.65
41_P47_A0.7600.64
13_K61_R0.7600.64
24_A83_Q0.7570.64
34_H38_N0.7480.63
3_D6_Y0.7360.62
54_F58_F0.7180.60
83_Q86_E0.7160.60
19_I50_L0.7100.59
54_F57_A0.6910.57
72_D77_K0.6760.55
4_Q7_N0.6760.55
19_I22_A0.6610.54
11_K14_L0.6560.53
15_S19_I0.6550.53
35_Q41_P0.6500.53
44_H64_E0.6460.52
45_A49_E0.6360.51
32_E48_K0.6330.51
5_V14_L0.6310.50
70_F77_K0.6270.50
59_V62_L0.6260.50
3_D43_S0.6250.50
82_E86_E0.6230.50
17_E60_D0.6170.49
31_Y54_F0.6010.47
70_F73_R0.5980.47
28_A52_A0.5940.46
84_A89_D0.5930.46
64_E67_G0.5900.46
2_Y7_N0.5780.45
66_K69_D0.5780.45
10_H69_D0.5720.44
17_E49_E0.5700.44
2_Y45_A0.5660.43
16_H64_E0.5520.42
31_Y34_H0.5440.41
19_I23_A0.5440.41
51_L55_A0.5430.41
85_E88_Y0.5410.40
22_A26_E0.5370.40
73_R86_E0.5290.39
5_V13_K0.5270.39
70_F78_H0.5220.38
37_K40_K0.5200.38
12_A65_T0.5180.38
15_S71_I0.5160.38
35_Q46_K0.5140.38
63_V73_R0.5110.37
60_D73_R0.5040.37
13_K43_S0.5020.36
15_S18_L0.5020.36
35_Q38_N0.5000.36
14_L19_I0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mraA 1 0.7582 4.1 0.932 Contact Map
3rznA 2 0.7802 3.4 0.935 Contact Map
3q23A 1 0.989 2.8 0.938 Contact Map
3kfuF 2 0.5495 2.6 0.939 Contact Map
4wj3B 2 0.5275 2.3 0.94 Contact Map
4emeA 4 0.3736 1.9 0.943 Contact Map
4k84A 1 0.7473 1.9 0.943 Contact Map
4k30A 2 0.3516 1.7 0.945 Contact Map
3ugsB 2 0.3846 1.7 0.945 Contact Map
2dxeA 5 0.5934 1.6 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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