GREMLIN Database
DUF3751 - Phage tail-collar fibre protein
PFAM: PF12571 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 150 (146)
Sequences: 2020 (1399)
Seq/√Len: 115.8
META: 0.535

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_E57_R4.4741.00
92_G100_L3.9131.00
12_A99_D3.5801.00
33_A94_F3.0351.00
16_K99_D2.9481.00
31_H57_R2.8701.00
28_N96_A2.8471.00
19_N23_L2.8311.00
33_A54_E2.6141.00
16_K95_D2.3481.00
63_L75_A2.3451.00
35_G90_E2.2071.00
11_N46_E2.0301.00
48_Q103_V2.0231.00
11_N47_T1.8831.00
58_A77_A1.8791.00
33_A57_R1.8731.00
29_I101_I1.8541.00
16_K97_D1.8341.00
76_E125_R1.8191.00
32_M77_A1.8051.00
95_D99_D1.8001.00
14_E46_E1.7991.00
36_D89_R1.7981.00
56_Y77_A1.7911.00
36_D53_N1.7461.00
60_I75_A1.6961.00
60_I63_L1.6841.00
72_Q127_I1.6071.00
87_W108_E1.5791.00
55_V86_F1.5451.00
84_G111_K1.5371.00
42_P48_Q1.5361.00
33_A50_A1.5211.00
110_Y116_E1.4901.00
75_A93_L1.4881.00
66_D69_N1.4511.00
34_V79_I1.4241.00
37_G90_E1.3901.00
12_A16_K1.3751.00
14_E132_N1.3721.00
11_N14_E1.3691.00
38_N53_N1.3641.00
31_H98_G1.3611.00
31_H59_P1.3581.00
72_Q129_E1.3371.00
91_I126_M1.3051.00
9_L14_E1.2650.99
91_I104_A1.2530.99
56_Y86_F1.2530.99
143_S146_L1.2390.99
114_L119_G1.2320.99
17_L21_A1.2300.99
95_D101_I1.2290.99
83_V86_F1.2260.99
42_P52_V1.2250.99
12_A15_A1.2080.99
88_I106_C1.1990.99
11_N15_A1.1960.99
69_N72_Q1.1650.99
7_T104_A1.1560.99
34_V77_A1.1520.99
94_F100_L1.1070.98
33_A51_L1.0870.98
91_I106_C1.0860.98
16_K101_I1.0840.98
52_V90_E1.0780.98
15_A19_N1.0680.98
102_A126_M1.0570.98
17_L27_L1.0550.98
43_T105_N1.0280.98
27_L101_I1.0230.97
112_P120_R1.0150.97
74_I125_R1.0090.97
34_V56_Y1.0090.97
89_R108_E1.0070.97
88_I122_L0.9930.97
100_L103_V0.9710.96
36_D39_G0.9420.96
41_P108_E0.9350.96
145_V148_T0.9280.95
91_I124_I0.9270.95
46_E132_N0.9130.95
28_N137_T0.9100.95
18_A22_A0.9040.95
29_I93_L0.9010.95
81_E121_T0.8770.94
44_P105_N0.8680.94
145_V149_R0.8560.93
14_E21_A0.8510.93
142_P146_L0.8330.92
51_L90_E0.8270.92
20_A27_L0.8240.92
12_A19_N0.8100.91
17_L101_I0.8020.91
18_A130_V0.7970.90
34_V58_A0.7960.90
69_N129_E0.7740.89
32_M60_I0.7680.89
38_N89_R0.7670.89
42_P103_V0.7590.88
21_A135_A0.7570.88
57_R98_G0.7530.88
66_D74_I0.7490.87
93_L126_M0.7480.87
65_V128_L0.7450.87
36_D55_V0.7430.87
34_V124_I0.7430.87
36_D108_E0.7300.86
32_M75_A0.7300.86
87_W110_Y0.7250.86
39_G111_K0.7210.85
130_V133_A0.7170.85
79_I82_D0.7150.85
139_K142_P0.7130.85
30_T96_A0.7120.85
67_P71_N0.7020.84
61_N76_E0.6980.83
143_S148_T0.6960.83
50_A54_E0.6940.83
35_G52_V0.6940.83
109_T120_R0.6910.83
141_D144_V0.6900.83
8_I45_D0.6860.82
23_L139_K0.6850.82
57_R94_F0.6800.82
9_L17_L0.6790.82
144_V147_A0.6740.81
62_S76_E0.6710.81
18_A73_I0.6620.80
64_S74_I0.6600.80
130_V136_V0.6590.80
56_Y83_V0.6550.79
107_P117_G0.6530.79
102_A128_L0.6520.79
64_S76_E0.6500.79
123_T127_I0.6500.79
32_M126_M0.6470.78
66_D72_Q0.6420.78
10_T13_G0.6390.78
85_G117_G0.6370.77
8_I47_T0.6320.77
109_T122_L0.6260.76
30_T59_P0.6250.76
66_D70_P0.6240.76
36_D87_W0.6240.76
8_I46_E0.6240.76
17_L135_A0.6220.76
140_I145_V0.6200.75
25_T115_A0.6200.75
107_P118_S0.6190.75
86_F111_K0.6130.75
5_Y109_T0.6110.74
107_P110_Y0.6100.74
29_I128_L0.6080.74
104_A126_M0.6070.74
14_E71_N0.6060.74
110_Y113_L0.6040.74
91_I105_N0.6000.73
107_P111_K0.5990.73
36_D44_P0.5990.73
15_A143_S0.5990.73
9_L102_A0.5980.73
35_G54_E0.5960.73
18_A21_A0.5900.72
13_G101_I0.5860.71
42_P105_N0.5850.71
10_T92_G0.5830.71
37_G51_L0.5810.71
33_A92_G0.5810.71
20_A23_L0.5800.71
9_L130_V0.5790.70
43_T46_E0.5790.70
115_A144_V0.5740.70
21_A133_A0.5730.70
16_K27_L0.5710.69
4_K21_A0.5710.69
44_P48_Q0.5690.69
50_A92_G0.5690.69
16_K19_N0.5680.69
48_Q52_V0.5650.69
37_G41_P0.5630.68
45_D48_Q0.5620.68
21_A26_P0.5620.68
118_S122_L0.5610.68
20_A80_P0.5600.68
109_T117_G0.5580.68
31_H54_E0.5580.68
123_T145_V0.5570.67
21_A101_I0.5540.67
8_I48_Q0.5470.66
37_G52_V0.5420.65
66_D127_I0.5420.65
79_I84_G0.5380.65
81_E114_L0.5370.65
34_V55_V0.5360.65
138_L144_V0.5360.65
17_L130_V0.5360.65
12_A49_T0.5350.64
29_I63_L0.5310.64
6_Y9_L0.5290.64
14_E48_Q0.5260.63
45_D103_V0.5250.63
55_V58_A0.5250.63
13_G29_I0.5220.63
4_K116_E0.5200.62
85_G113_L0.5150.61
133_A136_V0.5130.61
7_T126_M0.5120.61
29_I64_S0.5120.61
32_M122_L0.5110.61
32_M78_V0.5060.60
13_G20_A0.5040.60
20_A135_A0.5040.60
99_D102_A0.5030.60
139_K144_V0.5030.60
136_V147_A0.5010.59
32_M56_Y0.5010.59
16_K20_A0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k4qA 1 0.4933 8.6 0.93 Contact Map
2y2wA 3 0.1333 4.2 0.939 Contact Map
2kutA 1 0.58 2.7 0.945 Contact Map
2ayaA 1 0.4533 2.3 0.947 Contact Map
4ng0A 1 0.2867 2.1 0.948 Contact Map
4rgwA 1 0.88 2.1 0.948 Contact Map
1vraB 2 0.9867 2 0.948 Contact Map
3it4B 2 0.98 1.9 0.949 Contact Map
1vz6A 2 0.9467 1.7 0.951 Contact Map
2jx5A 1 0.24 1.6 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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