GREMLIN Database
DUF3750 - Protein of unknown function (DUF3750)
PFAM: PF12570 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 129 (128)
Sequences: 3775 (1976)
Seq/√Len: 174.7
META: 0.922

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_A75_E4.0001.00
110_L118_L3.8431.00
80_R115_E3.6631.00
57_R62_R3.4391.00
69_V77_L3.4381.00
8_A20_V3.3141.00
28_P82_E2.7571.00
4_V81_I2.7121.00
28_P79_P2.4601.00
28_P31_A2.2881.00
89_P108_W2.0501.00
82_E86_A1.9991.00
43_R48_R1.8831.00
83_A87_S1.8821.00
53_A56_G1.8671.00
52_R56_G1.8461.00
8_A66_L1.8261.00
87_S108_W1.7231.00
8_A22_T1.7141.00
37_Y49_I1.6901.00
19_A96_A1.5891.00
38_E48_R1.4981.00
81_I109_V1.4981.00
74_A79_P1.4801.00
5_Q68_D1.4771.00
108_W112_A1.4741.00
37_Y82_E1.4631.00
35_T49_I1.4181.00
113_V116_L1.4161.00
11_T15_R1.4011.00
35_T82_E1.3851.00
45_P91_A1.3851.00
85_V105_F1.3771.00
29_A74_A1.3761.00
26_V37_Y1.3531.00
106_V109_V1.3491.00
72_A75_E1.3321.00
82_E85_V1.3231.00
73_G76_A1.3151.00
22_T106_V1.2971.00
122_P128_D1.2841.00
33_R51_G1.2711.00
49_I85_V1.2281.00
119_D122_P1.2231.00
24_I109_V1.1961.00
39_V47_V1.1901.00
47_V91_A1.1831.00
4_V77_L1.1711.00
11_T96_A1.1691.00
36_R50_N1.1651.00
37_Y85_V1.1361.00
55_D63_P1.1111.00
36_R56_G1.0801.00
36_R52_R1.0791.00
38_E52_R1.0741.00
69_V73_G1.0731.00
25_A36_R1.0691.00
123_T128_D1.0671.00
38_E50_N1.0571.00
67_A110_L1.0420.99
20_V123_T1.0310.99
75_E79_P1.0280.99
12_G15_R1.0150.99
123_T127_K1.0150.99
87_S112_A1.0150.99
107_A111_R1.0120.99
121_P124_A0.9990.99
33_R50_N0.9890.99
72_A76_A0.9590.99
104_T108_W0.9560.99
76_A80_R0.9470.99
67_A118_L0.9360.99
3_V68_D0.9240.99
12_G61_N0.9040.99
7_Y10_R0.9000.99
14_W18_F0.8960.98
40_V43_R0.8870.98
77_L113_V0.8790.98
86_A91_A0.8700.98
40_V48_R0.8600.98
84_A113_V0.8570.98
26_V85_V0.8500.98
5_Q70_R0.8470.98
36_R39_V0.8320.98
45_P89_P0.8300.97
59_F62_R0.8300.97
28_P35_T0.8250.97
45_P48_R0.7780.96
76_A79_P0.7770.96
100_P103_N0.7730.96
44_G92_N0.7690.96
74_A77_L0.7660.96
62_R65_L0.7630.96
26_V81_I0.7630.96
13_G17_I0.7590.96
77_L80_R0.7590.96
3_V7_Y0.7550.96
22_T26_V0.7550.96
34_Y68_D0.7530.96
118_L121_P0.7470.95
110_L116_L0.7450.95
81_I113_V0.7310.95
13_G18_F0.7210.94
7_Y65_L0.7130.94
35_T85_V0.7120.94
6_V110_L0.7100.94
122_P127_K0.7090.94
45_P92_N0.7060.94
36_R48_R0.7050.94
14_W17_I0.7050.94
26_V49_I0.7030.94
19_A123_T0.7010.93
79_P83_A0.6960.93
80_R83_A0.6950.93
125_I128_D0.6870.93
12_G17_I0.6850.93
104_T129_Y0.6770.92
51_G56_G0.6740.92
38_E53_A0.6720.92
5_Q65_L0.6660.92
26_V35_T0.6620.91
3_V70_R0.6580.91
16_G42_W0.6550.91
73_G79_P0.6550.91
90_Y108_W0.6500.91
126_G129_Y0.6490.91
40_V59_F0.6460.90
73_G77_L0.6410.90
49_I82_E0.6400.90
94_Y99_G0.6390.90
84_A105_F0.6390.90
50_N53_A0.6380.90
24_I106_V0.6360.90
64_E67_A0.6350.90
4_V9_A0.6350.90
110_L119_D0.6270.89
12_G40_V0.6230.89
111_R128_D0.6190.88
102_S105_F0.6180.88
12_G59_F0.6180.88
97_W127_K0.6120.88
43_R46_P0.6100.88
10_R123_T0.6090.88
59_F63_P0.6050.87
104_T127_K0.6040.87
70_R73_G0.6040.87
79_P82_E0.6040.87
6_V118_L0.6000.87
61_N64_E0.5960.86
32_A73_G0.5950.86
28_P74_A0.5930.86
120_L123_T0.5920.86
17_I36_R0.5910.86
22_T124_A0.5880.86
46_P93_D0.5870.86
36_R43_R0.5850.85
124_A127_K0.5800.85
10_R61_N0.5800.85
78_I85_V0.5750.84
67_A116_L0.5730.84
97_W128_D0.5710.84
84_A112_A0.5700.84
93_D108_W0.5680.84
43_R57_R0.5660.84
96_A104_T0.5620.83
17_I97_W0.5560.82
5_Q9_A0.5550.82
29_A73_G0.5520.82
27_K55_D0.5450.81
5_Q34_Y0.5430.81
12_G43_R0.5410.81
14_W60_G0.5400.81
44_G48_R0.5390.81
107_A129_Y0.5350.80
44_G50_N0.5340.80
68_D111_R0.5330.80
5_Q111_R0.5280.79
46_P91_A0.5280.79
39_V93_D0.5240.79
27_K31_A0.5240.79
33_R87_S0.5220.78
20_V64_E0.5220.78
58_W63_P0.5220.78
25_A56_G0.5140.77
99_G103_N0.5130.77
80_R112_A0.5100.77
90_Y128_D0.5100.77
5_Q11_T0.5080.77
25_A46_P0.5070.76
15_R125_I0.5050.76
15_R18_F0.5050.76
4_V69_V0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lehA 5 0.9457 10.4 0.946 Contact Map
4ekxC 2 0.4419 4.1 0.955 Contact Map
4f0wA 1 0.3721 3.9 0.956 Contact Map
1c1dA 1 0.9457 3.9 0.956 Contact Map
1jogA 2 0.4496 3.9 0.956 Contact Map
3vpiA 1 0.3798 3.3 0.957 Contact Map
4lj1A 1 0.4341 3 0.958 Contact Map
2uw1A 2 0.8605 3 0.958 Contact Map
1wwpA 2 0.3411 3 0.958 Contact Map
4i6pA 2 0.3411 2.5 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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