GREMLIN Database
DUF3748 - Protein of unknown function (DUF3748)
PFAM: PF12566 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 123 (121)
Sequences: 851 (556)
Seq/√Len: 50.5
META: 0.814

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_E14_R5.7791.00
55_D61_T4.2281.00
86_N100_N4.0681.00
83_F105_G3.6171.00
73_V82_S3.3321.00
60_F89_V2.7341.00
93_L97_H2.5841.00
34_H88_H2.3341.00
21_P24_P2.2041.00
29_Q34_H2.1561.00
75_S79_Q2.1391.00
7_F42_A2.0531.00
8_S74_F1.9801.00
71_V82_S1.9160.99
36_Q50_N1.8960.99
8_S11_E1.7510.99
33_H91_A1.7490.99
19_H36_Q1.7380.99
88_H92_Q1.6820.98
24_P28_W1.6560.98
13_N43_D1.5710.97
80_W109_P1.5530.97
13_N42_A1.5520.97
2_C19_H1.5510.97
8_S14_R1.5470.97
101_L105_G1.4670.96
88_H103_N1.4580.96
37_G72_H1.4150.95
94_D97_H1.4020.95
10_V75_S1.3880.95
74_F77_D1.3780.95
6_T73_V1.3690.94
40_V48_A1.3450.94
83_F107_S1.2990.93
33_H88_H1.2920.92
33_H100_N1.2870.92
22_E28_W1.2670.92
15_V40_V1.2180.90
93_L99_L1.2070.90
86_N90_L1.1970.89
32_F54_R1.1840.89
80_W103_N1.1580.88
93_L101_L1.1540.87
40_V45_P1.1430.87
38_V50_N1.1420.87
32_F86_N1.0810.84
91_A100_N1.0800.84
51_L81_V1.0740.83
88_H91_A1.0620.83
7_F13_N1.0500.82
69_S83_F1.0460.82
8_S79_Q1.0450.82
93_L96_G1.0400.81
98_D101_L0.9990.79
56_I88_H0.9980.79
17_F20_G0.9970.78
39_I51_L0.9910.78
90_L100_N0.9860.78
14_R39_I0.9750.77
7_F11_E0.9720.77
44_R47_V0.9720.77
55_D116_P0.9670.76
22_E50_N0.9440.75
21_P28_W0.9400.74
21_P29_Q0.9290.73
115_V118_D0.9180.72
25_T30_Y0.9150.72
41_D44_R0.9140.72
94_D104_V0.9080.72
28_W34_H0.9020.71
92_Q97_H0.8660.68
54_R61_T0.8610.68
72_H105_G0.8520.67
57_T118_D0.8500.67
86_N91_A0.8390.66
29_Q33_H0.8310.65
33_H86_N0.8300.65
74_F101_L0.8140.63
52_D62_P0.8050.62
60_F104_V0.8010.62
83_F101_L0.7940.61
27_D30_Y0.7920.61
92_Q95_T0.7850.60
57_T116_P0.7830.60
74_F92_Q0.7830.60
32_F90_L0.7810.60
40_V49_I0.7770.60
32_F56_I0.7740.59
16_V51_L0.7660.58
2_C25_T0.7650.58
76_P94_D0.7610.58
64_A80_W0.7590.58
82_S108_V0.7560.57
24_P29_Q0.7540.57
25_T28_W0.7480.57
43_D112_P0.7470.57
7_F74_F0.7470.57
5_V54_R0.7440.56
88_H109_P0.7210.54
91_A103_N0.7200.54
94_D99_L0.7140.53
76_P80_W0.7120.53
89_V105_G0.7110.53
26_P114_R0.7080.53
29_Q92_Q0.7080.53
69_S104_V0.6990.52
31_G86_N0.6890.51
47_V112_P0.6890.51
69_S76_P0.6860.50
31_G34_H0.6730.49
54_R69_S0.6710.49
13_N16_V0.6670.48
5_V18_I0.6610.48
6_T16_V0.6590.48
4_V71_V0.6580.47
23_N80_W0.6570.47
81_V107_S0.6550.47
96_G106_V0.6520.47
16_V71_V0.6470.46
7_F19_H0.6470.46
62_P116_P0.6420.46
5_V32_F0.6410.46
86_N103_N0.6380.45
4_V21_P0.6370.45
46_G51_L0.6370.45
114_R118_D0.6360.45
70_H84_T0.6210.44
38_V48_A0.6180.43
32_F123_H0.6180.43
11_E41_D0.6080.42
74_F94_D0.6060.42
78_G103_N0.6060.42
26_P41_D0.5990.41
51_L107_S0.5990.41
10_V13_N0.5970.41
47_V106_V0.5970.41
60_F64_A0.5960.41
44_R49_I0.5950.41
38_V51_L0.5920.41
73_V103_N0.5880.40
41_D49_I0.5840.40
50_N57_T0.5810.40
14_R49_I0.5800.40
74_F103_N0.5740.39
74_F109_P0.5720.39
21_P25_T0.5720.39
43_D77_D0.5690.38
54_R123_H0.5690.38
32_F100_N0.5660.38
95_T118_D0.5650.38
16_V81_V0.5630.38
53_A76_P0.5570.37
5_V13_N0.5570.37
96_G99_L0.5560.37
79_Q111_R0.5520.37
10_V77_D0.5510.37
29_Q49_I0.5500.37
33_H38_V0.5480.36
74_F79_Q0.5460.36
93_L98_D0.5430.36
7_F83_F0.5420.36
10_V79_Q0.5410.36
117_K120_P0.5400.36
21_P30_Y0.5390.36
53_A65_L0.5360.35
4_V18_I0.5330.35
34_H91_A0.5320.35
8_S13_N0.5310.35
44_R118_D0.5220.34
95_T98_D0.5190.34
92_Q98_D0.5190.34
7_F14_R0.5190.34
43_D114_R0.5160.33
71_V100_N0.5150.33
50_N89_V0.5130.33
13_N95_T0.5120.33
60_F65_L0.5100.33
44_R96_G0.5090.33
57_T61_T0.5060.33
21_P36_Q0.5040.32
95_T99_L0.5020.32
15_V123_H0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wjlA 2 0.878 59.8 0.933 Contact Map
1xfdA 2 0.8374 44.1 0.939 Contact Map
2z3zA 2 0.7886 36.3 0.942 Contact Map
1z68A 2 0.8618 27.3 0.945 Contact Map
4bp8A 1 0.7886 25 0.946 Contact Map
4cj0B 1 0.2764 22.7 0.947 Contact Map
4a5sA 2 0.8211 22.1 0.948 Contact Map
2ecfA 2 0.7886 21.9 0.948 Contact Map
3c5mA 1 0.6829 19.7 0.949 Contact Map
2xe4A 1 0.8211 19.1 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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