GREMLIN Database
DUF3744 - ATP-binding cassette cobalt transporter
PFAM: PF12558 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 73 (73)
Sequences: 1387 (1161)
Seq/√Len: 135.9
META: 0.727

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_V71_L5.1571.00
64_P67_E3.8631.00
2_D6_E3.2541.00
11_E19_K2.5911.00
44_E48_E2.5861.00
9_I16_T2.1251.00
18_L37_L2.0101.00
46_L50_F1.8791.00
23_V42_D1.7961.00
8_G16_T1.7761.00
3_L7_N1.7011.00
25_I31_P1.6681.00
39_L42_D1.6561.00
10_R13_L1.5491.00
27_P31_P1.5171.00
29_M42_D1.5131.00
43_K47_R1.5071.00
30_H36_T1.3291.00
32_S36_T1.3071.00
18_L23_V1.2801.00
28_E31_P1.2681.00
44_E47_R1.2471.00
48_E52_S1.2381.00
5_K9_I1.2101.00
15_I32_S1.2031.00
46_L49_W1.1840.99
23_V46_L1.1660.99
18_L46_L1.1550.99
4_L9_I1.1530.99
19_K34_I1.1430.99
45_K48_E1.1230.99
15_I33_H1.1210.99
17_A21_A1.0650.99
38_D42_D1.0410.99
30_H38_D1.0260.99
57_E60_P1.0180.98
16_T20_Y0.9850.98
11_E16_T0.9790.98
15_I31_P0.9480.98
42_D45_K0.9260.97
38_D41_E0.9020.97
31_P36_T0.9010.97
24_D28_E0.8930.96
24_D45_K0.8690.96
16_T21_A0.8630.96
17_A46_L0.8470.95
55_P60_P0.8460.95
5_K19_K0.8320.95
33_H36_T0.8320.95
33_H68_V0.8140.94
42_D46_L0.7970.93
5_K11_E0.7850.93
58_K61_E0.7820.93
38_D44_E0.7810.93
38_D56_P0.7790.93
13_L73_F0.7690.92
54_P61_E0.7590.92
25_I29_M0.7430.91
10_R17_A0.7280.90
24_D29_M0.7260.90
4_L17_A0.7190.89
66_L71_L0.7070.89
29_M41_E0.7040.88
55_P58_K0.6990.88
8_G18_L0.6800.87
53_V71_L0.6720.86
29_M38_D0.6660.85
64_P68_V0.6630.85
28_E36_T0.6590.85
21_A49_W0.6560.85
5_K16_T0.6560.85
16_T19_K0.6500.84
26_T29_M0.6370.83
7_N16_T0.6370.83
48_E61_E0.6230.81
3_L6_E0.6140.81
49_W66_L0.6120.80
52_S62_K0.6080.80
11_E14_Y0.6070.80
35_D43_K0.6050.80
47_R57_E0.6050.80
20_Y42_D0.5940.78
25_I35_D0.5910.78
53_V62_K0.5810.77
23_V32_S0.5800.77
56_P59_K0.5770.76
32_S37_L0.5760.76
1_S7_N0.5680.75
23_V37_L0.5640.75
58_K62_K0.5630.75
7_N51_E0.5630.75
44_E52_S0.5630.75
37_L65_L0.5610.74
70_N73_F0.5480.73
25_I39_L0.5470.72
22_G45_K0.5460.72
24_D27_P0.5360.71
61_E65_L0.5350.71
26_T59_K0.5320.70
5_K72_S0.5310.70
41_E73_F0.5300.70
52_S55_P0.5300.70
1_S4_L0.5290.70
1_S19_K0.5250.69
7_N19_K0.5160.68
64_P69_E0.5130.68
17_A37_L0.5070.67
25_I71_L0.5060.67
25_I49_W0.5050.66
11_E50_F0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dajA 1 0.3562 16.7 0.873 Contact Map
4yycA 2 0.8767 12.9 0.88 Contact Map
3iecE 1 0.0822 11.9 0.881 Contact Map
2qneA 2 0.8767 11 0.883 Contact Map
2zu0C 1 0.1233 8.5 0.889 Contact Map
2w4lA 3 0.589 6.8 0.894 Contact Map
3cmuA 1 0.8904 6.7 0.894 Contact Map
3kkaC 1 0.7671 6.5 0.894 Contact Map
3h8mA 1 0.7808 6 0.896 Contact Map
1a9xA 3 0.9589 5.8 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0047 seconds.