GREMLIN Database
TPPK_C - Thiamine pyrophosphokinase C terminal
PFAM: PF12555 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 52 (51)
Sequences: 4136 (2180)
Seq/√Len: 305.3
META: 0.908

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_S15_P3.4501.00
2_G5_R2.8671.00
31_V37_G2.3251.00
23_A26_A2.1291.00
28_V32_A1.9431.00
43_L47_R1.9141.00
39_D43_L1.8391.00
2_G7_Y1.7511.00
45_W49_R1.6101.00
34_S37_G1.5571.00
38_R41_L1.4701.00
11_V19_L1.4581.00
13_G17_L1.3991.00
3_V6_L1.3751.00
48_L51_L1.3231.00
47_R50_D1.3061.00
1_K4_S1.2881.00
24_L28_V1.2851.00
26_A29_V1.2161.00
46_L50_D1.2151.00
25_V29_V1.1741.00
39_D42_D1.0911.00
40_L43_L1.0881.00
10_R14_W1.0731.00
11_V15_P1.0221.00
19_L22_A1.0161.00
42_D46_L0.9791.00
16_L22_A0.9691.00
20_V34_S0.9421.00
8_R11_V0.9401.00
46_L49_R0.9381.00
30_A37_G0.9361.00
7_Y25_V0.9321.00
1_K5_R0.9271.00
18_L25_V0.9131.00
19_L23_A0.8681.00
47_R51_L0.8581.00
45_W48_L0.8571.00
4_S8_R0.8541.00
33_V36_A0.8221.00
42_D45_W0.7881.00
30_A36_A0.7650.99
30_A44_L0.7280.99
31_V35_P0.7280.99
23_A27_L0.7130.99
19_L39_D0.6980.99
14_W21_L0.6920.99
9_S12_S0.6890.99
17_L21_L0.6810.99
5_R16_L0.6750.98
4_S9_S0.6630.98
21_L26_A0.6620.98
4_S47_R0.6540.98
19_L26_A0.6490.98
34_S42_D0.6310.98
20_V24_L0.6280.98
23_A30_A0.6240.97
27_L34_S0.6040.97
2_G38_R0.5910.97
17_L20_V0.5890.96
29_V33_V0.5790.96
15_P23_A0.5760.96
4_S7_Y0.5670.96
41_L44_L0.5670.96
1_K49_R0.5640.95
10_R15_P0.5620.95
1_K36_A0.5560.95
41_L45_W0.5430.94
26_A33_V0.5300.94
43_L46_L0.5270.94
14_W26_A0.5170.93
32_A38_R0.5140.93
20_V23_A0.5140.93
14_W35_P0.5100.92
21_L31_V0.5020.92
14_W17_L0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ixzA 1 1 11.7 0.804 Contact Map
3tx3A 2 0.7692 10.2 0.808 Contact Map
2m8rA 1 0.7308 9.8 0.81 Contact Map
3ar4A 1 1 9.4 0.811 Contact Map
2zxeA 1 0.9615 5.8 0.829 Contact Map
4pd6A 3 0.9808 4.9 0.835 Contact Map
3ux4A 3 1 2.2 0.862 Contact Map
4c7rA 3 0.8269 1.8 0.868 Contact Map
3gzfA 2 0.3462 1.7 0.869 Contact Map
2wswA 3 0.8269 1.7 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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