GREMLIN Database
DUF3739 - Filamentous haemagglutinin family outer membrane protein
PFAM: PF12545 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 110 (110)
Sequences: 1501 (840)
Seq/√Len: 80.1
META: 0.869

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_V88_I4.2821.00
32_I38_V4.0961.00
52_G82_R3.7661.00
66_D87_N3.6091.00
86_L101_V2.9831.00
33_D37_N2.7351.00
18_G49_S2.6341.00
10_N71_R2.5791.00
12_D73_T2.5781.00
101_V105_S2.4271.00
76_A81_I2.3451.00
81_I99_I2.3361.00
68_I89_A2.3181.00
14_D75_D2.3141.00
73_T92_Q2.2521.00
73_T94_L1.9071.00
73_T91_L1.8071.00
6_I13_I1.7251.00
105_S108_V1.6201.00
76_A99_I1.5811.00
64_D85_N1.5350.99
14_D17_R1.5340.99
54_L82_R1.5230.99
22_A49_S1.5150.99
87_N106_T1.5010.99
78_D97_D1.4810.99
28_P45_L1.4180.99
85_N103_G1.4100.99
85_N104_T1.3620.99
41_D44_G1.3310.98
30_V40_V1.3120.98
88_I93_V1.3070.98
81_I88_I1.2540.98
7_W70_P1.2310.97
57_V60_V1.2260.97
53_T83_S1.2220.97
25_A49_S1.2140.97
20_K98_N1.2090.97
55_A83_S1.2000.97
68_I87_N1.1470.96
74_V93_V1.1190.95
17_R23_V1.0830.95
42_L45_L1.0480.93
22_A25_A1.0440.93
31_L39_T1.0360.93
4_I52_G0.9750.91
88_I99_I0.9710.91
55_A60_V0.9680.90
47_T54_L0.9620.90
85_N101_V0.9540.90
86_L105_S0.9310.89
31_L41_D0.9110.88
4_I65_V0.9080.87
23_V46_V0.9020.87
5_L10_N0.8940.87
63_G83_S0.8880.86
25_A56_T0.8860.86
29_R41_D0.8740.85
77_G80_G0.8600.84
53_T65_V0.8580.84
90_A93_V0.8520.84
26_P45_L0.8410.83
25_A42_L0.8400.83
5_L68_I0.8330.82
44_G56_T0.8240.82
94_L99_I0.8220.82
45_L63_G0.8140.81
32_I37_N0.8130.81
28_P38_V0.8080.80
20_K78_D0.8080.80
96_A99_I0.8080.80
75_D95_N0.7850.79
26_P56_T0.7740.78
75_D94_L0.7710.77
105_S109_P0.7700.77
7_W89_A0.7630.77
13_I38_V0.7570.76
60_V63_G0.7500.75
29_R43_A0.7310.73
19_A78_D0.7280.73
93_V110_V0.7270.73
14_D45_L0.7210.72
29_R40_V0.7150.72
95_N98_N0.7140.72
38_V87_N0.7130.72
58_P61_P0.7090.71
65_V70_P0.7080.71
27_P54_L0.7060.71
74_V86_L0.7040.71
45_L53_T0.7000.70
33_D39_T0.6970.70
68_I74_V0.6880.69
6_I9_S0.6870.69
97_D100_Q0.6870.69
91_L102_G0.6860.69
74_V81_I0.6860.69
3_D66_D0.6800.68
60_V64_D0.6770.68
76_A88_I0.6770.68
92_Q97_D0.6690.67
28_P42_L0.6660.66
74_V92_Q0.6660.66
17_R49_S0.6640.66
14_D49_S0.6600.66
23_V56_T0.6550.65
6_I110_V0.6500.65
46_V66_D0.6490.64
81_I95_N0.6430.64
61_P83_S0.6310.62
89_A93_V0.6310.62
15_A18_G0.6300.62
25_A28_P0.6260.62
82_R95_N0.6240.61
100_Q104_T0.6220.61
96_A100_Q0.6200.61
93_V99_I0.6200.61
84_G93_V0.6160.60
45_L52_G0.6110.60
46_V55_A0.6100.60
4_I51_I0.6090.59
55_A62_P0.6050.59
55_A59_G0.6010.58
20_K101_V0.5970.58
21_T54_L0.5910.57
19_A56_T0.5890.57
14_D18_G0.5870.57
77_G95_N0.5840.56
82_R100_Q0.5840.56
56_T60_V0.5790.56
9_S61_P0.5690.54
51_I67_L0.5660.54
47_T52_G0.5620.54
57_V63_G0.5620.54
17_R22_A0.5580.53
66_D85_N0.5570.53
14_D23_V0.5540.52
62_P84_G0.5530.52
55_A63_G0.5510.52
18_G23_V0.5460.51
44_G47_T0.5460.51
28_P36_G0.5460.51
104_T110_V0.5450.51
18_G28_P0.5440.51
62_P83_S0.5420.51
25_A44_G0.5410.51
37_N46_V0.5400.51
7_W67_L0.5400.51
21_T90_A0.5360.50
23_V43_A0.5360.50
19_A28_P0.5330.50
23_V45_L0.5300.49
67_L74_V0.5290.49
33_D36_G0.5260.49
24_S43_A0.5260.49
29_R32_I0.5230.48
87_N91_L0.5190.48
94_L97_D0.5170.48
37_N49_S0.5140.47
53_T63_G0.5100.47
65_V86_L0.5080.47
49_S52_G0.5080.47
23_V54_L0.5030.46
46_V54_L0.5020.46
83_S86_L0.5020.46
60_V83_S0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rwrA 1 0.9727 9.3 0.939 Contact Map
2odlA 1 0.9455 7.4 0.942 Contact Map
2v2fA 1 0.1364 2.9 0.952 Contact Map
1v1hA 3 0.3273 2.7 0.953 Contact Map
4i84A 1 0.8091 2.5 0.954 Contact Map
3vsfA 1 0.1545 1.8 0.957 Contact Map
2q07A 1 0.9 1.6 0.958 Contact Map
3a0cA 2 0.6 1.5 0.959 Contact Map
3tekA 1 0.3364 1.3 0.96 Contact Map
4e01A 3 0.2273 1.2 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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