GREMLIN Database
CWC25 - Pre-mRNA splicing factor
PFAM: PF12542 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 92 (91)
Sequences: 638 (474)
Seq/√Len: 49.7
META: 0.373

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_R66_A3.2961.00
80_Q83_A3.2601.00
66_A70_R3.1291.00
78_K81_E2.9071.00
64_D68_K2.6531.00
25_Y28_G2.4441.00
63_R70_R2.2951.00
23_E26_L2.2751.00
83_A87_A2.0991.00
82_Q85_Y2.0491.00
88_L91_N1.9620.99
23_E27_L1.9090.99
86_E90_N1.7890.99
84_A87_A1.7780.99
81_E85_Y1.7670.99
42_E45_K1.7550.99
65_T75_L1.7070.98
5_L91_N1.7030.98
50_P54_F1.5550.97
15_G18_V1.5530.97
20_E24_E1.4670.96
17_G20_E1.4630.96
50_P53_L1.4440.96
52_S55_A1.4310.95
41_N45_K1.3950.95
74_L78_K1.3280.93
26_L29_K1.3230.93
6_D10_Q1.2990.92
33_D36_L1.2700.91
67_A70_R1.2570.91
24_E65_T1.2270.90
63_R67_A1.2190.90
8_M24_E1.2040.89
74_L77_I1.1930.89
88_L92_P1.1780.88
74_L81_E1.1680.88
41_N44_L1.1540.87
52_S56_E1.0890.84
3_E8_M1.0540.82
66_A71_E1.0370.81
51_G54_F0.9990.78
30_K33_D0.9970.78
32_V74_L0.9810.77
14_S21_E0.9770.76
80_Q84_A0.9580.75
14_S32_V0.9370.73
64_D70_R0.9350.73
38_G41_N0.9010.70
32_V76_A0.8920.70
67_A79_K0.8910.70
79_K82_Q0.8910.70
68_K74_L0.8830.69
74_L83_A0.8800.69
51_G55_A0.8600.67
82_Q86_E0.8530.66
42_E46_K0.8520.66
63_R68_K0.8440.65
35_L46_K0.8300.64
51_G57_Q0.8140.63
74_L91_N0.8030.61
70_R75_L0.7940.61
66_A91_N0.7860.60
23_E30_K0.7800.59
78_K82_Q0.7780.59
48_A55_A0.7760.59
40_E43_K0.7700.58
16_G19_T0.7650.58
61_S82_Q0.7630.58
5_L84_A0.7510.56
81_E89_M0.7490.56
67_A81_E0.7480.56
78_K85_Y0.7450.56
70_R79_K0.7440.56
24_E29_K0.7430.56
29_K33_D0.7360.55
35_L40_E0.7360.55
38_G44_L0.7350.55
24_E35_L0.7290.54
10_Q69_I0.7280.54
79_K83_A0.7210.53
30_K34_K0.7180.53
39_D42_E0.7140.53
4_R68_K0.7040.52
7_W89_M0.7010.51
11_G18_V0.7000.51
50_P55_A0.6990.51
28_G31_R0.6900.50
6_D39_D0.6870.50
25_Y34_K0.6830.49
39_D90_N0.6820.49
5_L31_R0.6790.49
38_G46_K0.6780.49
71_E76_A0.6710.48
75_L85_Y0.6700.48
31_R68_K0.6460.46
2_Q77_I0.6430.45
69_I81_E0.6410.45
7_W63_R0.6390.45
23_E47_A0.6340.44
23_E28_G0.6320.44
18_V22_M0.6310.44
64_D80_Q0.6300.44
77_I80_Q0.6260.44
9_Y72_D0.6190.43
6_D11_G0.6170.43
4_R64_D0.6130.42
76_A83_A0.6120.42
26_L30_K0.6120.42
9_Y73_P0.6020.41
5_L8_M0.6010.41
6_D32_V0.5980.41
64_D75_L0.5950.41
49_A52_S0.5900.40
47_A51_G0.5860.40
68_K78_K0.5790.39
76_A92_P0.5710.38
87_A90_N0.5710.38
34_K37_K0.5710.38
76_A85_Y0.5690.38
67_A86_E0.5640.38
49_A54_F0.5600.37
89_M92_P0.5560.37
24_E34_K0.5520.36
12_P66_A0.5490.36
52_S58_N0.5340.35
25_Y29_K0.5260.34
20_E75_L0.5250.34
22_M34_K0.5250.34
64_D67_A0.5160.33
69_I92_P0.5150.33
83_A86_E0.5120.33
32_V35_L0.5060.32
41_N84_A0.5060.32
21_E34_K0.5030.32
36_L39_D0.5030.32
6_D87_A0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fr7A 2 0.7609 4.6 0.91 Contact Map
2lnmA 1 0.2717 4.3 0.911 Contact Map
2qsfX 1 0.2065 3.4 0.916 Contact Map
2llwA 1 0.4239 2.1 0.924 Contact Map
2llvA 1 0.4565 1.8 0.927 Contact Map
1oqyA 1 0.6739 1.8 0.927 Contact Map
3j39D 1 0.9891 1.4 0.931 Contact Map
4w20D 1 0.9674 1.4 0.931 Contact Map
1pveA 1 0.2826 1.3 0.932 Contact Map
1yybA 1 0.2609 1.2 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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