GREMLIN Database
DUF3734 - Patatin phospholipase
PFAM: PF12536 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 106 (104)
Sequences: 7945 (4293)
Seq/√Len: 421.0
META: 0.945

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_Y91_R3.5981.00
26_E40_E2.9871.00
30_K40_E2.8631.00
84_Q88_A2.5801.00
30_K38_D2.4411.00
28_L45_A2.4241.00
30_K35_L2.3111.00
25_R50_E2.2991.00
33_E36_R2.2541.00
13_R16_Q2.2491.00
38_D41_V2.0921.00
77_A81_E1.8431.00
73_E78_S1.7761.00
76_R80_R1.7481.00
26_E29_A1.6581.00
23_A44_L1.6401.00
80_R84_Q1.6391.00
37_D42_R1.6191.00
97_P100_L1.5961.00
32_P35_L1.5171.00
42_R45_A1.4031.00
12_D15_K1.3951.00
7_T11_T1.3791.00
75_S78_S1.3611.00
31_L41_V1.3351.00
88_A92_R1.3141.00
33_E37_D1.3031.00
43_E46_A1.2881.00
28_L31_L1.2721.00
84_Q87_Y1.2701.00
20_L23_A1.2701.00
35_L38_D1.2691.00
9_S13_R1.2651.00
18_H21_R1.2581.00
11_T55_I1.2501.00
8_R11_T1.1851.00
25_R29_A1.1661.00
10_N13_R1.1611.00
87_Y90_T1.1471.00
98_P101_A1.1471.00
20_L47_Y1.1341.00
91_R95_A1.1271.00
27_L41_V1.1181.00
14_Q53_M1.0981.00
36_R45_A1.0901.00
19_R43_E1.0751.00
60_Y82_H1.0731.00
18_H51_T1.0681.00
96_H100_L1.0581.00
24_I27_L1.0521.00
60_Y63_K1.0501.00
36_R41_V1.0411.00
13_R17_I1.0401.00
88_A95_A1.0201.00
4_S8_R0.9971.00
20_L24_I0.9891.00
21_R48_G0.9691.00
24_I28_L0.9691.00
17_I21_R0.9661.00
28_L41_V0.9621.00
17_I20_L0.9621.00
69_S73_E0.9391.00
12_D16_Q0.9331.00
7_T15_K0.9321.00
15_K19_R0.9071.00
69_S72_Y0.9051.00
66_E82_H0.8801.00
31_L36_R0.8791.00
23_A43_E0.8751.00
31_L35_L0.8581.00
11_T57_H0.8581.00
40_E43_E0.8531.00
26_E43_E0.8471.00
92_R95_A0.8441.00
41_V45_A0.8291.00
65_Y81_E0.8251.00
90_T94_L0.8211.00
35_L41_V0.8111.00
88_A91_R0.8101.00
22_H49_C0.8011.00
39_P42_R0.8001.00
62_R69_S0.8001.00
19_R52_V0.7971.00
38_D42_R0.7941.00
22_H26_E0.7851.00
2_Q9_S0.7771.00
60_Y66_E0.7651.00
96_H101_A0.7621.00
19_R22_H0.7541.00
58_L90_T0.7541.00
49_C53_M0.7491.00
92_R96_H0.7471.00
56_V93_T0.7451.00
72_Y82_H0.7421.00
89_D92_R0.7391.00
28_L32_P0.7311.00
67_G79_M0.7261.00
26_E30_K0.7261.00
28_L48_G0.7251.00
42_R46_A0.7191.00
4_S9_S0.7181.00
6_R66_E0.7151.00
101_A104_D0.7101.00
93_T96_H0.7101.00
22_H50_E0.7041.00
54_H99_W0.7031.00
52_V102_R0.6981.00
18_H22_H0.6931.00
63_K81_E0.6901.00
43_E47_Y0.6841.00
67_G73_E0.6801.00
100_L103_P0.6761.00
15_K70_K0.6761.00
94_L97_P0.6731.00
14_Q17_I0.6731.00
2_Q10_N0.6630.99
44_L48_G0.6560.99
63_K66_E0.6530.99
24_I41_V0.6480.99
6_R18_H0.6450.99
98_P103_P0.6430.99
94_L103_P0.6420.99
71_D74_F0.6330.99
95_A100_L0.6280.99
95_A102_R0.6220.99
26_E38_D0.6220.99
27_L31_L0.5960.99
37_D45_A0.5960.99
20_L43_E0.5950.99
8_R59_I0.5930.99
40_E44_L0.5920.99
63_K85_A0.5890.99
21_R49_C0.5880.99
18_H49_C0.5860.99
64_D68_H0.5780.99
25_R48_G0.5700.98
47_Y50_E0.5670.98
4_S7_T0.5630.98
22_H25_R0.5570.98
25_R47_Y0.5450.98
81_E84_Q0.5440.98
62_R82_H0.5400.98
7_T89_D0.5390.98
77_A80_R0.5380.98
96_H103_P0.5380.98
97_P103_P0.5370.98
66_E78_S0.5370.98
60_Y79_M0.5320.98
64_D81_E0.5320.98
78_S82_H0.5270.97
23_A26_E0.5240.97
9_S16_Q0.5210.97
63_K68_H0.5180.97
62_R66_E0.5140.97
83_W89_D0.5120.97
36_R39_P0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3t72q 1 0.6887 38.1 0.879 Contact Map
1ttyA 1 0.7264 32.4 0.884 Contact Map
2lfwA 1 0.8302 28.8 0.887 Contact Map
4g6dA 1 0.5377 28.3 0.887 Contact Map
3tu3B 1 0.5472 28.2 0.887 Contact Map
1s7oA 3 0.7264 26.6 0.889 Contact Map
3hugA 3 0.7264 24.3 0.891 Contact Map
2q1zA 1 0.7264 18.1 0.897 Contact Map
4nqwA 1 0.6509 17.2 0.898 Contact Map
1xsvA 2 0.7264 16.6 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0056 seconds.