GREMLIN Database
DUF3731 - DNA-K related protein
PFAM: PF12531 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 248 (248)
Sequences: 2178 (1484)
Seq/√Len: 94.2
META: 0.896

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
221_R225_E4.5451.00
163_E199_D3.6471.00
162_A187_L3.3911.00
121_D161_T3.3711.00
20_F61_G3.3001.00
120_G165_W2.9861.00
193_D196_R2.8381.00
120_G144_G2.8321.00
167_E205_R2.8231.00
104_L108_L2.7911.00
211_E224_R2.6331.00
166_L184_L2.5971.00
117_I158_P2.5951.00
166_L198_L2.5601.00
184_L206_V2.4401.00
147_V191_T2.3081.00
24_L27_W2.2891.00
22_D26_D2.2741.00
144_G187_L2.2721.00
49_W97_E2.2711.00
144_G165_W2.2451.00
188_A206_V2.2041.00
47_Q51_E2.1981.00
1_S4_H2.1261.00
128_K168_A2.0371.00
72_F76_A2.0221.00
192_G226_V1.9751.00
198_L202_L1.9591.00
204_E208_A1.9461.00
32_L59_V1.9321.00
36_Y74_R1.9181.00
36_Y52_W1.8701.00
73_Q115_T1.8421.00
207_A220_L1.8261.00
121_D164_R1.8251.00
105_A119_L1.8191.00
206_V223_V1.8131.00
27_W31_Q1.7961.00
12_A32_L1.7811.00
42_F48_C1.7751.00
185_A223_V1.7621.00
113_V158_P1.7461.00
216_P219_W1.7231.00
200_D204_E1.6951.00
52_W56_W1.6861.00
190_R226_V1.6721.00
188_A198_L1.6621.00
113_V117_I1.6501.00
167_E171_A1.6491.00
61_G150_Y1.6441.00
72_F119_L1.6291.00
64_N67_Q1.6131.00
69_Q73_Q1.5951.00
79_L105_A1.5571.00
190_R203_R1.5461.00
32_L55_L1.5371.00
208_A211_E1.5361.00
39_G52_W1.5231.00
113_V116_K1.5201.00
106_A139_A1.4901.00
45_E48_C1.4881.00
40_L48_C1.4861.00
7_R10_N1.4651.00
71_L108_L1.4641.00
167_E202_L1.4431.00
163_E202_L1.3900.99
181_A215_A1.3860.99
205_R208_A1.3790.99
190_R198_L1.3780.99
207_A224_R1.3760.99
161_T164_R1.3720.99
148_P153_L1.3710.99
53_W101_M1.3700.99
190_R223_V1.3500.99
211_E217_E1.3340.99
166_L188_A1.3070.99
207_A210_L1.3030.99
36_Y39_G1.2950.99
157_V162_A1.2800.99
163_E198_L1.2660.99
166_L206_V1.2640.99
243_P246_L1.2600.99
123_L136_L1.2480.99
75_L101_M1.2460.99
174_W184_L1.2440.99
83_G86_K1.2190.98
79_L143_L1.2160.98
69_Q112_P1.2120.98
168_A171_A1.2070.98
5_E9_L1.2060.98
149_L237_V1.1950.98
69_Q115_T1.1930.98
61_G151_G1.1900.98
189_R194_R1.1840.98
65_A69_Q1.1780.98
230_D233_E1.1640.98
159_P163_E1.1560.98
51_E55_L1.1540.98
174_W209_R1.1540.98
70_Q74_R1.1420.98
31_Q34_R1.1140.97
116_K157_V1.1080.97
200_D203_R1.0770.96
218_R229_L1.0760.96
68_Q107_S1.0690.96
87_K90_P1.0680.96
233_E236_R1.0620.96
36_Y71_L1.0610.96
57_R99_R1.0410.96
170_L202_L1.0370.96
203_R207_A1.0360.96
120_G187_L1.0330.95
239_G243_P1.0260.95
106_A120_G1.0230.95
86_K89_K1.0210.95
8_W12_A1.0160.95
204_E224_R1.0130.95
185_A210_L1.0100.95
124_L168_A1.0080.95
192_G197_D1.0030.95
184_L209_R1.0020.95
215_A220_L0.9970.95
203_R223_V0.9840.94
116_K229_L0.9810.94
70_Q73_Q0.9760.94
10_N51_E0.9710.94
207_A211_E0.9690.94
9_L55_L0.9620.93
56_W59_V0.9610.93
86_K90_P0.9610.93
220_L223_V0.9460.93
209_R213_A0.9380.93
144_G157_V0.9370.93
159_P195_A0.9350.92
84_K87_K0.9210.92
121_D124_L0.9200.92
141_G237_V0.9170.92
215_A219_W0.9150.92
218_R233_E0.9120.91
108_L190_R0.9120.91
18_P21_G0.9080.91
97_E152_P0.9080.91
117_I161_T0.9070.91
30_E67_Q0.9070.91
47_Q52_W0.9040.91
170_L209_R0.9010.91
29_I59_V0.8970.91
97_E102_W0.8950.91
222_L226_V0.8940.91
72_F111_L0.8910.90
158_P161_T0.8880.90
83_G87_K0.8860.90
81_P85_K0.8810.90
190_R200_D0.8790.90
117_I164_R0.8780.90
215_A222_L0.8780.90
97_E100_E0.8750.90
111_L115_T0.8660.89
185_A222_L0.8540.89
50_A94_N0.8520.88
218_R222_L0.8490.88
198_L203_R0.8460.88
99_R122_W0.8450.88
220_L224_R0.8430.88
103_R135_Q0.8410.88
183_A187_L0.8330.87
16_L32_L0.8300.87
21_G25_D0.8280.87
81_P84_K0.8280.87
245_G248_L0.8230.87
116_K129_K0.8220.87
122_W125_K0.8180.86
184_L187_L0.8170.86
243_P248_L0.8150.86
33_W67_Q0.8140.86
159_P202_L0.8140.86
147_V189_R0.8130.86
120_G145_A0.8130.86
181_A213_A0.8100.86
94_N97_E0.8070.86
171_A205_R0.8060.86
200_D207_A0.8050.85
193_D197_D0.7960.85
174_W177_P0.7960.85
223_V226_V0.7880.84
16_L59_V0.7800.84
102_W152_P0.7750.83
56_W63_L0.7660.82
103_R107_S0.7650.82
138_W142_R0.7640.82
242_L245_G0.7640.82
174_W206_V0.7630.82
219_W222_L0.7620.82
221_R227_V0.7610.82
166_L170_L0.7580.82
231_E234_E0.7570.82
57_R194_R0.7560.82
2_A45_E0.7520.81
202_L205_R0.7500.81
164_R168_A0.7470.81
210_L215_A0.7460.81
3_A7_R0.7440.81
26_D34_R0.7390.80
159_P187_L0.7380.80
117_I121_D0.7360.80
13_G17_R0.7340.80
7_R152_P0.7340.80
67_Q104_L0.7310.79
76_A118_E0.7310.79
185_A207_A0.7310.79
127_L132_E0.7280.79
118_E122_W0.7270.79
211_E220_L0.7250.79
103_R138_W0.7240.79
132_E135_Q0.7230.79
65_A155_T0.7150.78
216_P222_L0.7150.78
25_D28_R0.7140.78
240_E243_P0.7030.77
207_A223_V0.7000.76
231_E235_A0.6990.76
98_L105_A0.6970.76
229_L234_E0.6970.76
40_L43_P0.6960.76
17_R21_G0.6940.76
214_G218_R0.6890.75
6_A49_W0.6860.75
140_L143_L0.6750.74
19_G25_D0.6750.74
66_G140_L0.6740.74
217_E221_R0.6740.74
79_L140_L0.6690.73
139_A241_S0.6680.73
68_Q73_Q0.6670.73
97_E126_R0.6660.73
222_L227_V0.6660.73
54_I57_R0.6660.73
148_P196_R0.6660.73
162_A166_L0.6620.72
166_L202_L0.6590.72
183_A196_R0.6530.71
124_L161_T0.6530.71
210_L220_L0.6530.71
80_L122_W0.6490.71
54_I143_L0.6480.71
82_R89_K0.6470.71
182_F236_R0.6460.71
113_V143_L0.6440.70
227_V233_E0.6440.70
60_A107_S0.6420.70
88_K92_R0.6420.70
75_L78_L0.6420.70
164_R167_E0.6400.70
99_R135_Q0.6390.70
33_W36_Y0.6390.70
45_E49_W0.6380.70
124_L238_F0.6380.70
40_L187_L0.6360.69
137_L141_G0.6300.69
199_D204_E0.6290.69
99_R103_R0.6280.68
218_R238_F0.6270.68
239_G248_L0.6240.68
82_R85_K0.6210.68
127_L136_L0.6210.68
151_G155_T0.6200.67
49_W78_L0.6190.67
222_L230_D0.6180.67
13_G18_P0.6130.67
98_L107_S0.6120.66
72_F115_T0.6090.66
51_E54_I0.6070.66
122_W126_R0.6060.66
104_L141_G0.6010.65
221_R224_R0.6000.65
18_P25_D0.5960.64
215_A218_R0.5960.64
174_W179_P0.5930.64
91_K181_A0.5930.64
4_H127_L0.5910.64
74_R116_K0.5910.64
60_A108_L0.5900.64
3_A95_P0.5900.64
12_A15_C0.5890.63
20_F149_L0.5890.63
199_D217_E0.5880.63
33_W70_Q0.5880.63
16_L29_I0.5870.63
125_K128_K0.5840.63
67_Q144_G0.5830.63
162_A183_A0.5800.62
14_F43_P0.5770.62
53_W63_L0.5770.62
37_A70_Q0.5750.62
201_A214_G0.5740.62
9_L52_W0.5730.61
43_P49_W0.5690.61
229_L237_V0.5690.61
81_P90_P0.5670.61
59_V181_A0.5670.61
23_P26_D0.5660.60
68_Q150_Y0.5650.60
66_G100_E0.5640.60
175_K179_P0.5630.60
5_E13_G0.5560.59
148_P190_R0.5540.59
9_L12_A0.5540.59
199_D202_L0.5530.59
110_R150_Y0.5520.59
75_L104_L0.5520.59
182_F186_Q0.5510.58
99_R154_N0.5510.58
15_C32_L0.5460.58
102_W136_L0.5460.58
201_A204_E0.5450.58
33_W57_R0.5420.57
10_N14_F0.5420.57
199_D208_A0.5400.57
182_F222_L0.5400.57
110_R152_P0.5400.57
6_A48_C0.5390.57
229_L233_E0.5380.57
156_V174_W0.5380.57
140_L144_G0.5370.56
97_E154_N0.5370.56
100_E152_P0.5370.56
29_I110_R0.5310.56
50_A96_Q0.5310.56
10_N52_W0.5310.56
181_A184_L0.5280.55
6_A12_A0.5280.55
130_G133_D0.5270.55
5_E8_W0.5250.55
29_I33_W0.5250.55
218_R227_V0.5240.55
40_L75_L0.5230.55
66_G70_Q0.5230.55
95_P100_E0.5220.54
168_A172_L0.5220.54
211_E221_R0.5210.54
85_K90_P0.5210.54
133_D136_L0.5210.54
170_L206_V0.5210.54
147_V196_R0.5210.54
129_K184_L0.5200.54
214_G219_W0.5200.54
5_E40_L0.5200.54
13_G19_G0.5190.54
231_E237_V0.5190.54
41_Q48_C0.5190.54
55_L224_R0.5180.54
66_G72_F0.5170.54
7_R154_N0.5170.54
194_R197_D0.5160.54
159_P199_D0.5160.54
53_W97_E0.5160.54
138_W151_G0.5160.54
89_K95_P0.5150.53
8_W61_G0.5150.53
30_E39_G0.5130.53
71_L181_A0.5110.53
124_L143_L0.5110.53
24_L31_Q0.5100.53
227_V240_E0.5090.53
37_A139_A0.5080.52
121_D168_A0.5080.52
182_F219_W0.5050.52
180_A183_A0.5050.52
127_L172_L0.5040.52
22_D152_P0.5010.51
44_N82_R0.5010.51
157_V165_W0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4narA 2 0.3669 45.7 0.96 Contact Map
4db6A 1 0.75 19 0.967 Contact Map
1te4A 1 0.4073 17.1 0.968 Contact Map
4qmiA 1 0.7984 16.1 0.968 Contact Map
4g3aA 1 0.8145 15.6 0.968 Contact Map
1u6gC 1 0.8105 14.3 0.969 Contact Map
2qk1A 1 0.8105 14.2 0.969 Contact Map
3ez0A 2 0.625 12.1 0.97 Contact Map
4jw3C 1 0.3831 8.3 0.972 Contact Map
2vglA 1 0.7742 7.4 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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