GREMLIN Database
DUF3718 - Protein of unknown function (DUF3718)
PFAM: PF12514 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 66 (63)
Sequences: 656 (435)
Seq/√Len: 54.8
META: 0.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_S40_R4.3121.00
36_Q44_K4.1751.00
8_D49_K4.0921.00
31_I38_L2.9451.00
5_V38_L2.8411.00
34_N41_F2.7291.00
1_I13_L2.2761.00
8_D47_A1.9691.00
15_K21_R1.8050.99
45_N50_T1.3710.96
8_D48_V1.2770.94
53_F60_P1.2740.93
14_R23_K1.2700.93
3_E6_A1.2160.92
36_Q41_F1.1940.91
5_V13_L1.1720.90
17_L24_L1.1430.89
31_I51_G1.1290.88
16_K20_N1.1170.88
16_K31_I1.1040.87
10_K13_L1.1030.87
50_T54_L1.0410.84
6_A45_N1.0330.84
42_A47_A1.0160.83
48_V52_E0.9910.81
28_Y37_S0.9740.80
35_G47_A0.9730.80
5_V28_Y0.9560.79
42_A45_N0.9530.78
3_E7_A0.9430.78
25_R47_A0.9150.75
28_Y39_L0.9090.75
20_N49_K0.8990.74
18_K44_K0.8780.72
28_Y53_F0.8770.72
13_L54_L0.8690.72
6_A47_A0.8610.71
5_V59_L0.8560.70
8_D42_A0.8450.69
49_K53_F0.8390.69
39_L54_L0.8370.69
9_D12_R0.8310.68
12_R64_L0.8130.66
8_D50_T0.8010.65
9_D49_K0.8000.65
1_I20_N0.7970.65
18_K36_Q0.7940.65
55_A64_L0.7660.62
58_K61_I0.7610.61
24_L42_A0.7570.61
61_I64_L0.7420.59
54_L62_K0.7280.58
24_L38_L0.7250.58
34_N63_D0.7190.57
17_L20_N0.7180.57
29_D39_L0.6760.52
50_T56_K0.6750.52
59_L63_D0.6620.51
25_R53_F0.6610.51
51_G59_L0.6520.50
4_A8_D0.6490.49
27_I38_L0.6450.49
27_I31_I0.6420.49
11_L14_R0.6400.48
38_L54_L0.6390.48
11_L19_D0.6360.48
22_L29_D0.6330.48
18_K29_D0.6310.48
30_G35_G0.6240.47
43_A46_G0.6200.46
24_L32_V0.6150.46
41_F50_T0.6140.46
20_N27_I0.6090.45
28_Y38_L0.5950.44
17_L27_I0.5920.43
58_K62_K0.5910.43
3_E26_N0.5880.43
23_K27_I0.5860.43
6_A34_N0.5820.42
15_K64_L0.5810.42
23_K28_Y0.5780.42
51_G55_A0.5720.41
3_E39_L0.5710.41
28_Y40_R0.5650.41
43_A54_L0.5640.40
44_K48_V0.5630.40
19_D29_D0.5570.40
45_N62_K0.5450.38
54_L58_K0.5440.38
23_K40_R0.5320.37
37_S43_A0.5210.36
5_V51_G0.5120.35
29_D55_A0.5110.35
32_V64_L0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mklA 1 1 52.2 0.813 Contact Map
3lsgA 2 1 47.3 0.818 Contact Map
4fe7A 2 1 47.1 0.818 Contact Map
1bl0A 1 1 46.4 0.819 Contact Map
3oioA 1 1 43.4 0.822 Contact Map
3oouA 1 1 43.2 0.823 Contact Map
3ajiA 1 0.9394 41.5 0.824 Contact Map
3mn2A 1 1 40.3 0.826 Contact Map
3gbgA 1 1 39.1 0.827 Contact Map
1wdyA 1 0.9242 38.3 0.828 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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