GREMLIN Database
DUF3717 - Protein of unknown function (DUF3717)
PFAM: PF12512 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 67 (65)
Sequences: 1459 (681)
Seq/√Len: 84.4
META: 0.881

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_C31_V3.2291.00
18_S30_E2.8431.00
13_Y27_L2.7331.00
30_E64_A2.5401.00
40_L44_Y2.3211.00
27_L31_V2.1571.00
22_D25_I2.0911.00
54_L59_R1.8551.00
2_I62_W1.8491.00
59_R63_L1.7661.00
60_A64_A1.7481.00
49_A54_L1.5851.00
62_W66_Y1.5461.00
3_H6_D1.5261.00
18_S28_C1.4220.99
1_G48_E1.4090.99
8_E12_N1.4060.99
12_N38_Y1.3870.99
1_G7_I1.3870.99
12_N15_R1.3550.99
21_P25_I1.3550.99
13_Y17_R1.3020.98
8_E11_I1.2970.98
17_R40_L1.1670.97
46_E49_A1.1100.96
8_E38_Y1.0920.95
63_L66_Y1.0740.95
11_I38_Y1.0660.95
46_E53_S1.0440.94
17_R57_A1.0190.93
33_A58_A0.9980.93
55_P58_A0.9940.93
3_H42_V0.9730.92
28_C32_R0.9700.92
21_P24_G0.9620.91
44_Y53_S0.9280.90
20_S24_G0.9170.89
8_E15_R0.9130.89
49_A53_S0.9050.89
50_D53_S0.9050.89
47_D56_A0.8970.88
33_A37_V0.8910.88
41_M49_A0.8890.88
52_A59_R0.8890.88
35_A65_W0.8830.87
4_I42_V0.8660.86
37_V55_P0.8430.85
25_I32_R0.8380.84
6_D66_Y0.8380.84
56_A59_R0.8300.84
20_S38_Y0.7920.81
13_Y49_A0.7910.81
13_Y64_A0.7750.80
37_V40_L0.7650.79
47_D63_L0.7420.77
33_A61_A0.7420.77
22_D32_R0.7330.76
14_W38_Y0.7310.75
12_N27_L0.7250.75
44_Y57_A0.7240.75
5_T65_W0.7240.75
54_L57_A0.7180.74
18_S32_R0.7130.74
1_G6_D0.7120.74
25_I28_C0.7040.73
16_E46_E0.6990.72
49_A52_A0.6930.72
3_H66_Y0.6750.70
35_A45_R0.6710.69
14_W33_A0.6690.69
52_A57_A0.6490.67
1_G49_A0.6450.66
15_R38_Y0.6280.64
14_W30_E0.6190.63
58_A61_A0.6120.62
7_I49_A0.6050.61
21_P28_C0.5880.59
39_A43_Y0.5870.59
11_I15_R0.5770.58
9_A62_W0.5730.57
36_E40_L0.5680.56
41_M44_Y0.5670.56
1_G53_S0.5660.56
2_I27_L0.5520.54
19_P30_E0.5510.54
1_G50_D0.5390.53
8_E42_V0.5360.52
13_Y31_V0.5360.52
56_A63_L0.5340.52
48_E51_E0.5300.51
37_V43_Y0.5290.51
58_A62_W0.5280.51
31_V35_A0.5270.51
49_A57_A0.5180.50
22_D26_T0.5160.49
44_Y56_A0.5100.49
47_D57_A0.5020.48
14_W34_L0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lvcA 4 0.9254 23.1 0.868 Contact Map
4p29A 1 0.5224 12.9 0.882 Contact Map
2mhkA 1 0.6269 12.2 0.883 Contact Map
1v8bA 4 0.9254 10.2 0.887 Contact Map
3d64A 4 0.9254 9.9 0.888 Contact Map
3x2fA 4 0.9403 7.6 0.894 Contact Map
2marA 1 0.8657 6.4 0.897 Contact Map
2knzA 1 0.2985 5.8 0.899 Contact Map
2xsdC 1 0.9701 5.5 0.9 Contact Map
4k70A 2 0.8657 4.8 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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