GREMLIN Database
DUF3716 - Protein of unknown function (DUF3716)
PFAM: PF12511 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 59 (53)
Sequences: 526 (457)
Seq/√Len: 62.7
META: 0.517

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_Q45_A4.7561.00
11_A30_V4.2551.00
4_I45_A3.2091.00
48_H51_G2.2291.00
50_N53_G1.8731.00
4_I40_F1.7610.99
4_I31_V1.7100.99
3_L9_E1.6650.99
40_F48_H1.5090.98
27_E46_N1.4400.98
1_A25_F1.4020.97
5_Q27_E1.3460.97
4_I48_H1.3310.96
9_E13_Q1.2750.96
17_R50_N1.2670.95
18_C28_C1.2490.95
25_F49_W1.2070.94
10_V27_E1.1670.93
20_K45_A1.1470.92
8_G15_C1.1310.92
2_L51_G1.0860.90
3_L6_A1.0810.90
52_Q55_R1.0540.89
43_A48_H1.0480.88
3_L58_L1.0420.88
10_V31_V1.0400.88
17_R52_Q0.9830.85
17_R55_R0.9560.83
24_P46_N0.9400.82
2_L10_V0.9230.81
5_Q24_P0.9060.80
15_C18_C0.8820.78
23_G50_N0.8710.77
19_A22_R0.8570.76
7_R29_V0.8560.76
50_N55_R0.8450.75
43_A58_L0.8390.74
11_A14_P0.8260.73
10_V19_A0.8080.71
3_L38_G0.7840.69
16_T19_A0.7820.69
18_C44_C0.7410.65
18_C47_C0.7110.62
16_T22_R0.7080.61
44_C56_C0.7060.61
23_G30_V0.7040.61
40_F51_G0.6770.58
13_Q57_S0.6750.58
24_P51_G0.6740.57
13_Q22_R0.6690.57
45_A49_W0.6670.57
9_E26_A0.6630.56
20_K23_G0.6520.55
19_A39_L0.6490.55
41_G54_S0.6470.54
2_L6_A0.6390.53
9_E43_A0.6250.52
39_L42_G0.6230.52
6_A10_V0.6230.52
14_P29_V0.6130.50
6_A39_L0.6080.50
7_R42_G0.5910.48
49_W54_S0.5900.48
37_P53_G0.5860.47
7_R41_G0.5810.47
3_L51_G0.5730.46
16_T37_P0.5710.46
16_T20_K0.5650.45
48_H53_G0.5610.45
38_G41_G0.5600.44
2_L37_P0.5520.43
31_V45_A0.5380.42
8_G11_A0.5280.41
16_T57_S0.5260.41
20_K50_N0.5190.40
4_I54_S0.5150.39
16_T46_N0.5110.39
23_G46_N0.5100.39
15_C56_C0.5100.39
10_V30_V0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e84A 1 1 15.9 0.832 Contact Map
2cvcA 1 1 7.7 0.854 Contact Map
3oueA 1 0.8305 5.9 0.862 Contact Map
3ov0A 3 0.8305 5.6 0.864 Contact Map
1ofwA 2 1 3.6 0.875 Contact Map
1f4sP 1 0.8983 3.6 0.875 Contact Map
1zmeC 2 0.5593 3.5 0.876 Contact Map
1co4A 1 0.4407 3.4 0.877 Contact Map
1z1nX 1 0.8983 3.4 0.877 Contact Map
3ouqA 2 0.8644 2.9 0.881 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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