GREMLIN Database
DUF3712 - Protein of unknown function (DUF3712)
PFAM: PF12505 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 125 (121)
Sequences: 935 (787)
Seq/√Len: 71.6
META: 0.199

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_T72_T4.1831.00
45_E79_N3.7791.00
88_S105_T3.5271.00
78_L81_L3.3241.00
46_S74_T3.0641.00
18_T21_I2.7341.00
45_E76_K2.6551.00
50_T70_N2.3901.00
31_V35_T2.2211.00
5_T11_I2.1941.00
43_T80_G2.1381.00
95_T99_G2.0161.00
87_S105_T1.9761.00
50_T72_T1.9651.00
33_A36_D1.9081.00
34_F81_L1.8881.00
7_T10_P1.8641.00
46_S76_K1.8071.00
83_G109_P1.7421.00
87_S107_T1.5920.99
4_G26_L1.5700.99
39_K43_T1.5340.99
94_G100_I1.5250.99
9_P53_G1.5060.99
42_L67_I1.4870.99
95_T98_D1.4580.99
93_G101_N1.4450.99
28_I31_V1.4140.98
52_S70_N1.3770.98
18_T51_L1.3450.98
40_A44_N1.3330.98
57_V71_K1.3120.97
76_K90_D1.2990.97
21_I26_L1.2940.97
104_A121_V1.2590.97
36_D39_K1.2200.96
81_L118_L1.2090.96
48_T74_T1.2020.96
79_N83_G1.2010.96
90_D103_T1.1920.96
38_A64_L1.1860.95
80_G108_I1.1840.95
72_T108_I1.1570.95
41_L63_P1.1430.94
91_L94_G1.1350.94
33_A37_F1.1250.94
92_P95_T1.1220.94
3_F9_P1.1100.93
46_S117_E1.0950.93
39_K86_I1.0840.93
54_S68_P1.0670.92
36_D44_N1.0640.92
51_L98_D1.0630.92
48_T88_S1.0460.91
54_S73_V1.0430.91
5_T32_D1.0280.91
7_T12_K1.0250.90
58_A64_L1.0100.90
38_A112_S0.9890.89
59_A62_L0.9800.88
61_G64_L0.9600.87
38_A49_L0.9580.87
6_I24_Q0.9420.86
21_I24_Q0.9400.86
92_P99_G0.9150.85
10_P16_N0.9080.84
39_K44_N0.9050.84
3_F8_L0.9050.84
36_D40_A0.8940.83
81_L120_D0.8920.83
49_L89_F0.8920.83
8_L16_N0.8880.83
98_D101_N0.8810.82
57_V60_G0.8790.82
30_D56_T0.8780.82
72_T76_K0.8780.82
81_L108_I0.8680.81
118_L121_V0.8580.81
40_A86_I0.8570.81
58_A115_T0.8560.80
92_P103_T0.8560.80
19_T60_G0.8550.80
89_F93_G0.8530.80
69_F118_L0.8410.79
9_P13_A0.8410.79
17_G21_I0.8340.79
96_P100_I0.8340.79
80_G92_P0.8330.79
90_D94_G0.8320.79
36_D121_V0.7970.75
53_G78_L0.7940.75
72_T83_G0.7910.75
42_L91_L0.7860.74
62_L119_G0.7770.74
33_A45_E0.7750.73
69_F112_S0.7740.73
7_T25_T0.7720.73
17_G108_I0.7660.73
5_T10_P0.7580.72
100_I106_V0.7490.71
78_L116_L0.7470.71
12_K19_T0.7360.70
63_P85_T0.7290.69
57_V64_L0.7290.69
16_N19_T0.7270.69
7_T15_G0.7270.69
77_G110_N0.7260.68
50_T102_L0.7250.68
44_N116_L0.7250.68
42_L71_K0.7210.68
80_G111_P0.7120.67
37_F86_I0.7120.67
4_G13_A0.7110.67
79_N115_T0.7030.66
37_F47_V0.6990.66
3_F11_I0.6940.65
78_L112_S0.6890.64
26_L49_L0.6870.64
95_T101_N0.6770.63
69_F119_G0.6760.63
36_D85_T0.6740.63
36_D46_S0.6720.63
42_L64_L0.6700.62
58_A61_G0.6620.61
84_V101_N0.6550.61
6_I112_S0.6520.60
6_I9_P0.6490.60
41_L114_L0.6480.60
73_V103_T0.6450.59
70_N86_I0.6420.59
38_A116_L0.6410.59
45_E83_G0.6390.59
37_F80_G0.6320.58
44_N101_N0.6290.57
9_P16_N0.6290.57
49_L71_K0.6240.57
9_P22_V0.6230.57
24_Q64_L0.6170.56
95_T100_I0.6170.56
17_G20_V0.6170.56
86_I101_N0.6160.56
8_L15_G0.6160.56
56_T65_S0.5980.54
112_S119_G0.5980.54
56_T61_G0.5910.53
37_F119_G0.5840.52
108_I113_P0.5790.51
38_A41_L0.5760.51
93_G98_D0.5740.51
69_F78_L0.5730.51
73_V93_G0.5730.51
37_F49_L0.5720.51
89_F102_L0.5690.50
104_A107_T0.5660.50
103_T106_V0.5660.50
42_L62_L0.5650.50
61_G117_E0.5630.49
88_S103_T0.5510.48
11_I21_I0.5510.48
55_T120_D0.5490.48
3_F116_L0.5480.48
51_L73_V0.5450.47
56_T70_N0.5450.47
55_T67_I0.5420.47
92_P106_V0.5350.46
33_A104_A0.5350.46
56_T88_S0.5340.46
77_G85_T0.5310.46
24_Q65_S0.5270.45
54_S66_G0.5270.45
27_T75_L0.5260.45
22_V26_L0.5230.45
32_D74_T0.5200.44
3_F26_L0.5150.44
77_G81_L0.5120.43
8_L18_T0.5120.43
48_T85_T0.5110.43
30_D33_A0.5100.43
73_V118_L0.5070.43
41_L49_L0.5010.42
39_K78_L0.5010.42
40_A47_V0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xo8A 1 0.632 70.1 0.84 Contact Map
1yycA 1 0.632 64.7 0.846 Contact Map
3butA 2 0.336 39 0.868 Contact Map
2eihA 4 0.44 3.9 0.918 Contact Map
1wlyA 2 0.384 3.9 0.918 Contact Map
1g0dA 1 0.792 2.9 0.923 Contact Map
3jynA 2 0.448 2.7 0.924 Contact Map
3nx4A 2 0.44 2.7 0.924 Contact Map
4rvuA 2 0.448 2.5 0.926 Contact Map
1xi4A 8 0.648 2.3 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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