GREMLIN Database
DUF3710 - Protein of unknown function (DUF3710)
PFAM: PF12502 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 176 (174)
Sequences: 2143 (1341)
Seq/√Len: 101.7
META: 0.709

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_L150_V4.8331.00
127_G147_F4.3271.00
116_I129_I3.9561.00
53_L127_G3.2761.00
35_D38_T3.1071.00
51_S133_A2.8451.00
78_L83_G2.7861.00
129_I143_L2.6291.00
118_V147_F2.5891.00
19_S165_L2.5841.00
75_A96_L2.5201.00
53_L147_F2.4781.00
58_F126_R2.4561.00
71_R87_E2.2621.00
65_G119_D2.2321.00
19_S57_A2.2321.00
155_G159_M2.1591.00
89_E94_T2.0731.00
21_L153_V2.0221.00
5_V153_V1.9751.00
46_L146_V1.9131.00
118_V127_G1.8971.00
88_V97_R1.8561.00
17_L44_V1.8381.00
35_D40_Q1.8301.00
115_F128_V1.8161.00
95_E114_R1.8011.00
50_D132_P1.7181.00
76_A80_K1.7141.00
132_P136_D1.6551.00
57_A165_L1.6521.00
67_W117_G1.5991.00
91_P148_R1.5821.00
125_L150_V1.5591.00
8_V21_L1.5071.00
72_A87_E1.4911.00
73_E162_R1.4871.00
56_Q128_V1.4711.00
90_G95_E1.4641.00
92_F144_E1.4421.00
86_E97_R1.4341.00
33_E43_A1.4191.00
125_L147_F1.3901.00
104_T108_R1.3510.99
3_W9_P1.3340.99
3_W149_D1.3300.99
33_E45_T1.3290.99
68_D94_T1.3120.99
25_P149_D1.3090.99
84_T99_R1.3060.99
25_P28_M1.2870.99
53_L129_I1.2750.99
159_M165_L1.2660.99
54_Q115_F1.2640.99
98_A113_A1.2480.99
75_A79_R1.2440.99
78_L98_A1.2420.99
79_R84_T1.2000.99
103_A108_R1.1810.98
81_Q124_F1.1690.98
79_R85_A1.1690.98
33_E54_Q1.1560.98
99_R110_T1.1400.98
137_P144_E1.1360.98
11_D21_L1.1240.98
52_A130_S1.1200.98
65_G68_D1.1160.98
1_G4_D1.1130.98
61_P65_G1.1040.98
118_V148_R1.0990.98
140_A144_E1.0980.98
91_P144_E1.0920.97
62_R122_R1.0890.97
29_E47_V1.0730.97
168_R171_E1.0680.97
64_G119_D1.0540.97
17_L32_L1.0440.97
47_V52_A1.0390.97
9_P12_D1.0340.96
98_A115_F1.0310.96
141_A145_E1.0270.96
20_L55_L1.0200.96
68_D71_R1.0080.96
103_A109_T1.0030.96
6_S11_D0.9970.96
4_D121_P0.9960.96
87_E94_T0.9950.96
161_P164_L0.9930.95
125_L152_V0.9800.95
14_R21_L0.9750.95
41_V81_Q0.9680.95
137_P141_A0.9650.95
28_M46_L0.9490.94
144_E148_R0.9490.94
76_A79_R0.9440.94
70_V162_R0.9430.94
54_Q98_A0.9360.94
48_L142_P0.9330.94
54_Q113_A0.9240.93
11_D14_R0.9230.93
33_E52_A0.9010.93
87_E96_L0.8910.92
8_V11_D0.8860.92
159_M166_P0.8860.92
160_P165_L0.8780.92
121_P148_R0.8780.92
72_A76_A0.8720.91
102_V111_Q0.8720.91
68_D87_E0.8710.91
116_I147_F0.8680.91
5_V21_L0.8680.91
77_S81_Q0.8570.91
132_P135_V0.8550.90
5_V8_V0.8460.90
10_D14_R0.8450.90
75_A87_E0.8430.90
20_L152_V0.8400.90
115_F126_R0.8400.90
124_F128_V0.8390.90
92_F118_V0.8370.89
22_V150_V0.8340.89
129_I140_A0.8240.89
78_L115_F0.8210.89
129_I147_F0.8130.88
45_T55_L0.8080.88
88_V137_P0.7960.87
145_E149_D0.7930.87
130_S158_P0.7890.87
8_V12_D0.7820.86
61_P66_L0.7800.86
14_R151_V0.7780.86
14_R23_P0.7730.85
28_M33_E0.7720.85
76_A84_T0.7600.84
13_G24_V0.7600.84
78_L99_R0.7560.84
61_P122_R0.7540.84
9_P21_L0.7460.83
71_R94_T0.7440.83
56_Q78_L0.7350.82
69_E72_A0.7340.82
22_V40_Q0.7340.82
103_A106_D0.7280.82
55_L125_L0.7260.82
59_A122_R0.7250.82
129_I144_E0.7190.81
138_E141_A0.7080.80
113_A130_S0.7070.80
32_L36_E0.7050.80
106_D109_T0.7040.80
63_S122_R0.7040.80
19_S159_M0.6990.79
102_V105_P0.6960.79
86_E110_T0.6960.79
8_V23_P0.6950.79
30_L44_V0.6950.79
43_A54_Q0.6860.78
6_S9_P0.6830.78
68_D72_A0.6790.77
100_V135_V0.6780.77
148_R167_L0.6690.76
148_R156_D0.6680.76
25_P142_P0.6660.76
31_R74_I0.6650.76
119_D124_F0.6620.75
28_M48_L0.6610.75
36_E39_G0.6610.75
97_R112_P0.6610.75
75_A85_A0.6580.75
77_S80_K0.6570.75
66_L124_F0.6570.75
136_D139_A0.6550.75
116_I127_G0.6500.74
3_W8_V0.6480.74
14_R61_P0.6460.74
66_L119_D0.6450.73
45_T54_Q0.6450.73
154_R158_P0.6440.73
21_L24_V0.6410.73
86_E99_R0.6390.73
61_P118_V0.6380.73
130_S162_R0.6330.72
70_V73_E0.6320.72
68_D151_V0.6310.72
22_V47_V0.6300.72
33_E42_V0.6300.72
45_T52_A0.6230.71
39_G111_Q0.6220.71
104_T107_G0.6120.69
139_A142_P0.6060.69
167_L171_E0.6050.69
80_K135_V0.6030.68
59_A62_R0.6020.68
29_E34_V0.6020.68
45_T130_S0.5990.68
58_F129_I0.5980.68
143_L169_L0.5970.68
29_E169_L0.5970.68
70_V128_V0.5960.67
90_G118_V0.5950.67
157_E160_P0.5920.67
59_A154_R0.5840.66
71_R75_A0.5810.66
30_L33_E0.5790.65
157_E174_A0.5780.65
34_V41_V0.5780.65
5_V9_P0.5760.65
122_R154_R0.5750.65
48_L51_S0.5740.65
117_G124_F0.5710.64
54_Q134_A0.5700.64
40_Q47_V0.5650.63
32_L64_G0.5650.63
35_D56_Q0.5640.63
79_R137_P0.5600.63
59_A118_V0.5570.62
53_L69_E0.5550.62
83_G96_L0.5540.62
70_V124_F0.5500.61
23_P149_D0.5490.61
52_A111_Q0.5470.61
105_P109_T0.5470.61
115_F124_F0.5460.61
132_P165_L0.5460.61
16_D153_V0.5440.60
31_R47_V0.5440.60
78_L100_V0.5440.60
29_E50_D0.5430.60
85_A94_T0.5430.60
44_V57_A0.5370.59
83_G101_P0.5360.59
169_L172_E0.5360.59
41_V70_V0.5350.59
88_V94_T0.5350.59
115_F119_D0.5300.58
27_G112_P0.5280.58
54_Q128_V0.5280.58
8_V151_V0.5280.58
78_L128_V0.5270.58
13_G91_P0.5270.58
25_P45_T0.5210.57
92_F95_E0.5180.57
43_A158_P0.5170.57
160_P163_D0.5170.57
128_V158_P0.5170.57
103_A158_P0.5160.56
158_P164_L0.5150.56
63_S101_P0.5120.56
124_F130_S0.5120.56
12_D145_E0.5100.56
26_E172_E0.5070.55
132_P139_A0.5070.55
43_A57_A0.5040.55
28_M150_V0.5020.54
77_S128_V0.5020.54
114_R140_A0.5020.54
6_S10_D0.5020.54
22_V46_L0.5010.54
150_V163_D0.5010.54
119_D162_R0.5000.54
99_R112_P0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jrmA 1 0.5852 6.7 0.959 Contact Map
3fcgA 2 0.2159 5.2 0.961 Contact Map
3lydA 2 0.7784 4.6 0.962 Contact Map
4aneA 4 0.2614 3.5 0.964 Contact Map
2j0pA 1 0.392 3.2 0.965 Contact Map
4mf9A 1 0.392 3.1 0.965 Contact Map
1novD 1 0.1136 2.9 0.966 Contact Map
1f8vD 3 0.1648 2.8 0.966 Contact Map
4ftbD 1 0.1193 2.8 0.966 Contact Map
4cdpA 1 0.3864 2.7 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0069 seconds.