GREMLIN Database
DUF3708 - Phosphate ATP-binding cassette transporter
PFAM: PF12501 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 166 (164)
Sequences: 4568 (3810)
Seq/√Len: 297.5
META: 0.85

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_G137_R2.9741.00
105_A108_A2.8871.00
113_Y117_R2.7691.00
112_A116_L2.7501.00
8_A46_A2.5091.00
80_S83_E2.4851.00
113_Y116_L2.4611.00
116_L120_L2.4431.00
74_A77_L2.3911.00
15_G41_V2.3871.00
102_S105_A2.3601.00
112_A115_D2.3131.00
150_R153_M2.1751.00
16_R20_L2.0691.00
131_G137_R2.0261.00
133_G136_L2.0091.00
154_G158_A1.9731.00
11_A41_V1.9111.00
40_Y44_W1.8851.00
19_A30_L1.7611.00
120_L124_G1.7391.00
106_A109_A1.7351.00
114_A118_A1.6971.00
106_A110_A1.6701.00
55_L59_F1.6571.00
26_G29_R1.6511.00
114_A117_R1.6441.00
79_L83_E1.6011.00
143_R146_N1.5851.00
115_D120_L1.5601.00
31_H143_R1.5531.00
107_A110_A1.5221.00
65_T88_L1.5221.00
117_R121_A1.5051.00
25_G28_R1.4731.00
103_A106_A1.4611.00
63_I67_L1.4541.00
102_S106_A1.4491.00
131_G134_A1.4361.00
118_A122_A1.4361.00
65_T92_R1.3901.00
115_D118_A1.3751.00
47_L151_I1.3721.00
74_A78_P1.3611.00
113_Y121_A1.3531.00
115_D119_L1.3431.00
116_L119_L1.3411.00
17_R21_A1.3351.00
4_L8_A1.3241.00
102_S108_A1.3091.00
108_A111_A1.2931.00
114_A120_L1.2741.00
43_L151_I1.2681.00
104_A107_A1.2681.00
151_I155_L1.2651.00
145_R149_E1.2561.00
61_P65_T1.2551.00
31_H146_N1.2381.00
73_P76_V1.2371.00
43_L148_V1.2361.00
113_Y124_G1.2251.00
35_G39_A1.2211.00
40_Y142_F1.2161.00
113_Y119_L1.2111.00
161_A165_L1.1951.00
6_A10_A1.1901.00
101_L105_A1.1831.00
12_Y16_R1.1801.00
117_R120_L1.1701.00
104_A108_A1.1681.00
105_A110_A1.1651.00
19_A23_A1.1601.00
7_L45_C1.1411.00
131_G135_V1.1361.00
120_L123_V1.1111.00
76_V87_V1.1031.00
113_Y120_L1.1021.00
19_A22_L1.0951.00
52_L156_L1.0701.00
160_S163_A1.0581.00
121_A125_V1.0511.00
119_L124_G1.0331.00
69_L84_L1.0181.00
161_A164_I1.0171.00
86_L89_N1.0171.00
119_L122_A1.0141.00
87_V91_I1.0131.00
130_A133_G1.0081.00
23_A33_L1.0021.00
11_A45_C0.9961.00
56_W60_E0.9911.00
24_G27_G0.9861.00
7_L11_A0.9861.00
40_Y147_R0.9841.00
114_A123_V0.9641.00
58_A62_S0.9631.00
46_A50_L0.9511.00
134_A137_R0.9471.00
47_L51_L0.9411.00
41_V138_I0.9411.00
82_A85_S0.9351.00
130_A134_A0.9271.00
112_A120_L0.9231.00
59_F62_S0.9221.00
69_L88_L0.9211.00
103_A109_A0.9161.00
121_A124_G0.9141.00
101_L106_A0.8921.00
82_A86_L0.8771.00
51_L55_L0.8741.00
43_L47_L0.8661.00
131_G136_L0.8661.00
66_S70_A0.8621.00
42_A46_A0.8521.00
103_A108_A0.8481.00
113_Y122_A0.8461.00
101_L108_A0.8421.00
45_C49_A0.8411.00
22_L138_I0.8401.00
93_N99_I0.8381.00
107_A111_A0.8371.00
160_S164_I0.8341.00
111_A115_D0.8201.00
103_A107_A0.8201.00
130_A135_V0.8161.00
157_I161_A0.8151.00
117_R123_V0.8111.00
68_V71_S0.8001.00
145_R148_V0.7930.99
113_Y118_A0.7880.99
40_Y159_C0.7850.99
90_D93_N0.7830.99
158_A162_I0.7790.99
20_L24_G0.7690.99
102_S107_A0.7670.99
105_A109_A0.7670.99
154_G157_I0.7670.99
18_R21_A0.7640.99
89_N93_N0.7640.99
111_A114_A0.7590.99
87_V90_D0.7570.99
92_R96_S0.7500.99
101_L109_A0.7500.99
110_A113_Y0.7450.99
67_L71_S0.7400.99
22_L30_L0.7340.99
64_I68_V0.7330.99
60_E64_I0.7270.99
93_N98_N0.7240.99
112_A124_G0.7220.99
103_A110_A0.7180.99
115_D124_G0.7140.99
30_L34_P0.7100.99
17_R20_L0.7100.99
23_A26_G0.7050.99
116_L121_A0.7050.99
150_R154_G0.7030.99
18_R22_L0.7020.99
119_L123_V0.7000.99
117_R124_G0.7000.99
104_A110_A0.6950.99
72_L77_L0.6950.99
73_P77_L0.6940.99
149_E160_S0.6910.99
12_Y35_G0.6880.99
62_S66_S0.6850.98
151_I154_G0.6850.98
24_G29_R0.6850.98
152_V156_L0.6820.98
127_L136_L0.6750.98
10_A13_F0.6750.98
22_L140_P0.6730.98
9_A13_F0.6700.98
33_L36_Y0.6690.98
23_A27_G0.6630.98
156_L160_S0.6610.98
91_I95_A0.6590.98
118_A121_A0.6580.98
10_A14_L0.6570.98
128_A131_G0.6510.98
127_L130_A0.6470.98
35_G41_V0.6460.98
129_A133_G0.6460.98
155_L159_C0.6450.98
112_A117_R0.6450.98
113_Y125_V0.6410.98
122_A125_V0.6380.98
159_C164_I0.6340.98
101_L110_A0.6300.97
145_R159_C0.6250.97
113_Y123_V0.6230.97
112_A119_L0.6210.97
2_L6_A0.6140.97
157_I164_I0.6130.97
111_A119_L0.6100.97
114_A119_L0.6050.97
130_A136_L0.6030.97
111_A116_L0.6030.97
147_R150_R0.6020.97
53_L57_L0.5980.96
56_W64_I0.5970.96
114_A122_A0.5950.96
145_R160_S0.5900.96
32_S37_Y0.5900.96
114_A125_V0.5890.96
114_A121_A0.5870.96
77_L80_S0.5850.96
15_G138_I0.5810.96
25_G29_R0.5810.96
80_S84_L0.5780.96
149_E163_A0.5740.96
116_L124_G0.5730.96
149_E164_I0.5710.95
132_A136_L0.5660.95
31_H37_Y0.5660.95
132_A137_R0.5640.95
13_F16_R0.5630.95
114_A124_G0.5610.95
156_L159_C0.5530.95
159_C163_A0.5510.94
52_L160_S0.5500.94
116_L123_V0.5500.94
88_L91_I0.5500.94
104_A109_A0.5490.94
72_L91_I0.5470.94
88_L92_R0.5460.94
126_A130_A0.5450.94
36_Y148_V0.5360.94
83_E90_D0.5350.94
67_L70_A0.5320.93
22_L25_G0.5300.93
51_L58_A0.5290.93
127_L135_V0.5280.93
73_P91_I0.5210.93
147_R153_M0.5210.93
50_L54_A0.5190.93
101_L111_A0.5170.92
125_V128_A0.5150.92
25_G30_L0.5130.92
5_L9_A0.5110.92
19_A90_D0.5100.92
120_L125_V0.5090.92
130_A137_R0.5080.92
128_A134_A0.5070.92
68_V88_L0.5050.92
124_G128_A0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mofA 1 0.1566 19.7 0.927 Contact Map
2mfrA 1 0.1867 7.7 0.939 Contact Map
2ks1B 1 0.1446 6.8 0.941 Contact Map
2jwaA 2 0.1386 5.2 0.944 Contact Map
1iijA 1 0.1084 5.1 0.944 Contact Map
4us3A 1 0.3193 4.9 0.945 Contact Map
2m20A 2 0.247 4.8 0.945 Contact Map
2l2tA 2 0.1506 4.5 0.946 Contact Map
2k1kA 2 0.1084 4 0.947 Contact Map
2onkC 2 0.6325 3.5 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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