GREMLIN Database
DUF3703 - Protein of unknown function (DUF3703)
PFAM: PF12487 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 109 (107)
Sequences: 2386 (1687)
Seq/√Len: 163.1
META: 0.864

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_D25_A3.0651.00
93_V99_M2.8681.00
10_E29_H2.5991.00
55_G64_V2.5651.00
88_T99_M2.4191.00
14_A30_L2.2501.00
18_R26_A2.2431.00
54_F58_R2.1311.00
32_R104_D2.1201.00
10_E32_R1.9891.00
94_S97_K1.9571.00
41_T78_S1.8411.00
32_R102_P1.8051.00
40_Y43_P1.7651.00
45_V75_A1.7201.00
103_E106_Q1.7191.00
74_A78_S1.6271.00
11_L47_V1.5971.00
41_T74_A1.5971.00
49_W71_L1.5801.00
49_W53_R1.5691.00
46_R50_L1.5281.00
66_G91_A1.4941.00
18_R57_R1.4821.00
9_A13_A1.4821.00
52_L64_V1.4811.00
73_V77_G1.4641.00
65_L69_L1.4431.00
56_L64_V1.4371.00
39_P83_V1.3951.00
31_E90_G1.3761.00
50_L53_R1.3731.00
23_L58_R1.3611.00
41_T79_L1.3461.00
36_L105_L1.3301.00
73_V96_F1.2841.00
69_L96_F1.2301.00
6_A108_L1.2281.00
77_G81_G1.1801.00
69_L95_A1.1571.00
7_Y46_R1.1481.00
54_F90_G1.1281.00
23_L54_F1.1261.00
53_R57_R1.1091.00
8_E12_A1.1011.00
52_L71_L1.0931.00
11_L50_L1.0871.00
14_A26_A1.0841.00
17_A22_D1.0700.99
17_A25_A1.0650.99
35_I102_P1.0540.99
12_A16_A1.0380.99
14_A54_F1.0170.99
68_L72_V1.0030.99
37_G83_V0.9960.99
31_E92_N0.9860.99
61_R65_L0.9830.99
75_A78_S0.9710.99
12_A15_R0.9660.99
26_A54_F0.9570.99
4_R43_P0.9500.99
16_A20_A0.9410.99
33_A47_V0.9400.99
25_A29_H0.9360.99
70_R84_P0.9310.98
18_R53_R0.9200.98
85_V98_P0.9200.98
18_R50_L0.9020.98
8_E46_R0.8990.98
68_L101_I0.8930.98
78_S83_V0.8840.98
73_V82_R0.8790.98
30_L51_M0.8770.98
5_P9_A0.8640.98
41_T75_A0.8610.97
27_W90_G0.8580.97
7_Y11_L0.8550.97
102_P105_L0.8530.97
10_E13_A0.8440.97
27_W51_M0.8350.97
25_A28_R0.8270.97
101_I106_Q0.8240.97
84_P87_N0.8230.97
24_A31_E0.8220.97
55_G60_D0.8220.97
45_V77_G0.8100.96
27_W54_F0.8080.96
7_Y37_G0.8070.96
45_V74_A0.8020.96
3_L40_Y0.8010.96
32_R105_L0.7950.96
15_R19_A0.7820.96
39_P109_L0.7780.95
7_Y47_V0.7770.95
58_R90_G0.7730.95
106_Q109_L0.7730.95
76_L81_G0.7640.95
103_E107_A0.7620.95
73_V95_A0.7570.95
88_T92_N0.7510.95
35_I105_L0.7440.94
29_H32_R0.7390.94
41_T83_V0.7340.94
13_A16_A0.7330.94
20_A25_A0.7240.93
16_A19_A0.7230.93
9_A16_A0.7230.93
75_A79_L0.7070.93
37_G40_Y0.7020.92
7_Y43_P0.6950.92
41_T45_V0.6860.91
18_R54_F0.6860.91
17_A20_A0.6840.91
35_I39_P0.6810.91
13_A17_A0.6790.91
73_V76_L0.6680.90
70_R87_N0.6680.90
55_G63_E0.6580.90
45_V71_L0.6450.89
83_V94_S0.6380.88
100_P106_Q0.6220.87
6_A36_L0.6120.86
27_W80_V0.6100.86
37_G47_V0.6070.86
73_V78_S0.6060.85
42_G45_V0.5980.85
12_A21_G0.5950.84
91_A94_S0.5950.84
56_L61_R0.5920.84
78_S82_R0.5890.84
27_W41_T0.5830.83
69_L72_V0.5790.83
76_L83_V0.5750.82
74_A83_V0.5740.82
37_G74_A0.5740.82
35_I99_M0.5720.82
18_R21_G0.5720.82
41_T77_G0.5700.82
19_A24_A0.5650.81
4_R8_E0.5630.81
63_E91_A0.5620.81
101_I105_L0.5560.80
45_V73_V0.5510.80
93_V98_P0.5490.79
3_L7_Y0.5420.79
6_A9_A0.5390.78
39_P46_R0.5390.78
16_A24_A0.5360.78
90_G99_M0.5330.77
34_H67_Q0.5290.77
8_E20_A0.5280.77
41_T73_V0.5210.76
43_P50_L0.5170.75
5_P12_A0.5160.75
56_L62_R0.5140.75
24_A58_R0.5120.75
76_L80_V0.5050.74
23_L85_V0.5050.74
9_A12_A0.5010.73
91_A99_M0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4js0B 1 0.2294 10.8 0.937 Contact Map
4bluA 2 0.8624 8.8 0.939 Contact Map
2di0A 1 0.2202 8.7 0.94 Contact Map
4ui9C 2 0.4862 8.6 0.94 Contact Map
4lctA 2 0.7798 8.2 0.94 Contact Map
3b1fA 2 0.3761 8.1 0.94 Contact Map
2nygA 2 0.8532 7.9 0.941 Contact Map
2kygA 2 0.1743 7 0.942 Contact Map
3ijwA 2 0.8624 6.7 0.943 Contact Map
3ax2A 1 0.5688 6.2 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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