GREMLIN Database
PE_PPE_C - Polymorphic PE/PPE proteins C terminal
PFAM: PF12484 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (79)
Sequences: 2339 (1780)
Seq/√Len: 200.3
META: 0.681

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_G49_L2.1241.00
51_G56_G2.0281.00
34_P37_G1.9411.00
59_G62_G1.9381.00
45_A48_G1.8541.00
34_P38_A1.7971.00
57_M60_R1.7811.00
47_A50_G1.7381.00
57_M61_G1.6971.00
34_P41_A1.6721.00
54_L60_R1.6691.00
28_P31_A1.6141.00
45_A49_L1.5711.00
6_Q9_S1.5441.00
30_A33_L1.5061.00
56_G62_G1.5051.00
46_G50_G1.4441.00
6_Q17_P1.4121.00
27_R30_A1.4101.00
7_A14_S1.3601.00
66_A69_R1.3431.00
55_A60_R1.3411.00
68_P77_M1.3281.00
73_R79_R1.3241.00
71_G77_M1.2791.00
55_A59_G1.2121.00
56_G60_R1.1991.00
38_A41_A1.1961.00
9_S12_G1.1751.00
53_P56_G1.1661.00
39_A42_A1.1631.00
68_P75_T1.1591.00
3_G6_Q1.1521.00
70_Y76_V1.1501.00
3_G8_A1.1491.00
17_P20_A1.1271.00
51_G62_G1.1221.00
65_G69_R1.1201.00
5_G9_S1.1131.00
70_Y78_P1.1001.00
51_G54_L1.0791.00
25_A28_P1.0771.00
70_Y74_P1.0701.00
74_P77_M1.0601.00
35_G39_A1.0561.00
51_G61_G1.0511.00
38_A43_A1.0421.00
68_P74_P1.0281.00
36_T41_A1.0271.00
67_A75_T1.0011.00
44_A48_G0.9911.00
63_A71_G0.9811.00
34_P44_A0.9640.99
75_T79_R0.9600.99
51_G55_A0.9590.99
29_A32_A0.9530.99
29_A33_L0.9480.99
27_R33_L0.9280.99
27_R32_A0.9280.99
6_Q12_G0.9280.99
26_A30_A0.9140.99
65_G71_G0.8940.99
8_A15_V0.8830.99
69_R72_F0.8770.99
54_L59_G0.8690.99
65_G70_Y0.8690.99
67_A70_Y0.8340.98
22_A25_A0.8340.98
55_A58_A0.8330.98
42_A47_A0.8300.98
34_P40_A0.8280.98
58_A61_G0.8180.98
44_A47_A0.8060.98
42_A46_G0.8020.98
71_G78_P0.7820.98
27_R31_A0.7810.98
75_T78_P0.7720.97
34_P39_A0.7640.97
23_A26_A0.7610.97
21_A32_A0.7590.97
35_G40_A0.7520.97
22_A27_R0.7510.97
51_G60_R0.7410.97
65_G68_P0.7300.96
72_F75_T0.7280.96
8_A32_A0.7190.96
69_R77_M0.7180.96
53_P58_A0.7110.96
38_A42_A0.7100.96
37_G41_A0.7100.96
40_A44_A0.7090.96
39_A44_A0.6940.95
36_T39_A0.6850.95
8_A22_A0.6680.94
33_L44_A0.6670.94
36_T40_A0.6590.94
60_R63_A0.6470.93
42_A49_L0.6320.92
71_G76_V0.6320.92
66_A78_P0.6310.92
37_G46_G0.6290.92
7_A28_P0.6280.92
35_G38_A0.6240.92
63_A75_T0.6160.91
54_L61_G0.6160.91
10_V64_G0.6130.91
24_P27_R0.5730.88
21_A24_P0.5470.86
2_A5_G0.5390.85
65_G77_M0.5380.85
41_A50_G0.5290.84
17_P73_R0.5280.84
31_A46_G0.5240.83
26_A29_A0.5230.83
25_A31_A0.5070.81
65_G75_T0.5060.81
55_A62_G0.5030.81
55_A79_R0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dnvA 6 0.0875 1.3 0.909 Contact Map
3cp8A 2 0.3125 1 0.914 Contact Map
4jweC 1 0.1 1 0.915 Contact Map
2lkwA 1 0.125 0.9 0.918 Contact Map
3tk2A 1 0.2 0.7 0.923 Contact Map
4mguA 6 0.075 0.7 0.924 Contact Map
4x0qA 1 0.3 0.5 0.931 Contact Map
2al3A 1 0.225 0.5 0.933 Contact Map
3etoA 1 0.3375 0.5 0.933 Contact Map
4illA 2 0.275 0.4 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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