GREMLIN Database
DUF3696 - Protein of unknown function (DUF3696)
PFAM: PF12476 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 53 (47)
Sequences: 6462 (5390)
Seq/√Len: 786.2
META: 0.938

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_E49_D2.6761.00
2_S5_D2.4661.00
46_W50_L2.2781.00
30_D36_S2.1631.00
30_D34_R2.1001.00
3_P31_E2.0601.00
12_E21_E1.9951.00
47_D50_L1.8481.00
46_W49_D1.7371.00
21_E24_E1.5531.00
10_F42_F1.5401.00
24_E36_S1.4861.00
47_D51_A1.4621.00
20_L23_L1.4081.00
18_S21_E1.3441.00
6_V29_I1.2841.00
8_I29_I1.2061.00
21_E25_V1.1991.00
14_D17_G1.1921.00
19_S24_E1.1691.00
35_I38_W1.1451.00
45_E48_K1.1351.00
14_D18_S1.0081.00
40_E44_D0.9821.00
20_L24_E0.9751.00
8_I35_I0.9661.00
34_R51_A0.9001.00
48_K51_A0.8991.00
20_L25_V0.8951.00
38_W42_F0.8901.00
18_S23_L0.8761.00
34_R46_W0.8431.00
34_R50_L0.8421.00
14_D19_S0.8171.00
22_E25_V0.8081.00
35_I42_F0.8001.00
46_W51_A0.7821.00
25_V36_S0.7801.00
12_E40_E0.7721.00
44_D48_K0.7701.00
38_W43_F0.7701.00
29_I33_G0.7561.00
43_F46_W0.7481.00
41_G44_D0.7321.00
44_D47_D0.7161.00
34_R49_D0.6981.00
16_G22_E0.6741.00
34_R38_W0.6621.00
9_Y43_F0.6471.00
14_D20_L0.6111.00
19_S22_E0.6041.00
7_A22_E0.5991.00
35_I46_W0.5981.00
10_F41_G0.5821.00
37_N40_E0.5761.00
39_P42_F0.5741.00
12_E19_S0.5631.00
14_D48_K0.5601.00
2_S31_E0.5561.00
18_S25_V0.5501.00
11_F50_L0.5451.00
41_G45_E0.5311.00
36_S40_E0.5301.00
10_F35_I0.5191.00
11_F44_D0.5191.00
19_S23_L0.5121.00
38_W49_D0.5081.00
12_E39_P0.5061.00
34_R37_N0.5011.00
41_G46_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s1sA 1 1 4.3 0.847 Contact Map
3anwA 1 0.6981 3.8 0.852 Contact Map
3gl3A 3 1 2.5 0.865 Contact Map
1bgcA 1 0.3208 2.4 0.865 Contact Map
2ygkA 2 0.6038 2.3 0.867 Contact Map
4yodA 1 0.9811 2.2 0.869 Contact Map
3or5A 1 1 2.1 0.869 Contact Map
3hdcA 2 1 2 0.872 Contact Map
2c0dA 2 1 1.9 0.873 Contact Map
3psiA 1 0 1.9 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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