GREMLIN Database
DUF3694 - Kinesin protein
PFAM: PF12473 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 155 (147)
Sequences: 566 (365)
Seq/√Len: 30.1
META: 0.155

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_D108_H3.4051.00
21_G24_R3.3941.00
21_G25_R3.3271.00
120_N131_V2.9961.00
6_E17_Q2.7391.00
16_F148_V2.6011.00
5_V59_L2.4900.99
125_L146_I2.3380.99
104_D114_N2.2040.98
19_H112_L2.1780.98
105_S108_H2.0360.97
38_L127_L2.0140.97
114_N117_T2.0050.97
138_E142_F1.9810.97
125_L148_V1.9780.97
85_P133_S1.8730.96
60_D63_A1.8460.95
110_S117_T1.8400.95
85_P88_E1.7450.94
25_R28_V1.7140.93
55_P58_L1.6880.92
4_P21_G1.6650.92
59_L122_R1.6520.92
89_F92_D1.6360.91
79_L82_L1.6160.91
23_Q106_S1.5960.90
38_L133_S1.5730.90
21_G108_H1.5600.89
25_R105_S1.5490.89
63_A118_P1.5460.89
80_G83_S1.5390.88
106_S110_S1.5120.88
4_P51_V1.4770.86
76_D80_G1.4610.86
4_P20_Q1.4580.86
78_S83_S1.4550.85
75_P80_G1.4490.85
111_L118_P1.4480.85
38_L60_D1.4170.84
7_V153_R1.3880.83
69_D81_L1.3600.81
85_P89_F1.3190.79
4_P7_V1.3190.79
25_R104_D1.2980.78
69_D107_L1.2740.77
51_V99_A1.2690.76
117_T122_R1.2650.76
103_W108_H1.2260.74
74_T101_A1.2160.73
136_C154_D1.2040.73
22_L123_V1.2020.72
73_L76_D1.1950.72
130_D141_V1.1870.71
20_Q60_D1.1820.71
25_R108_H1.1770.71
140_V143_R1.1420.68
146_I150_I1.1310.68
2_Y117_T1.1130.66
135_P142_F1.1120.66
32_H35_G1.1110.66
80_G84_E1.0940.65
76_D128_S1.0940.65
11_S14_D1.0820.64
139_P145_D1.0770.64
19_H79_L1.0640.63
25_R106_S1.0540.62
105_S114_N1.0440.61
2_Y24_R1.0430.61
86_Y89_F1.0420.61
4_P153_R1.0390.61
24_R56_V1.0340.61
63_A67_I1.0320.60
12_D27_V1.0280.60
54_G57_R1.0220.60
75_P81_L1.0210.60
7_V23_Q1.0050.58
50_H54_G1.0040.58
25_R102_S0.9980.58
42_R51_V0.9970.58
13_L28_V0.9930.57
78_S84_E0.9730.56
5_V60_D0.9720.56
75_P82_L0.9610.55
105_S113_L0.9610.55
76_D82_L0.9520.54
82_L86_Y0.9460.54
11_S88_E0.9440.54
97_V133_S0.9200.52
72_S77_V0.9100.51
38_L100_E0.9020.50
30_L35_G0.8980.50
84_E92_D0.8970.50
19_H42_R0.8930.50
16_F128_S0.8880.49
13_L38_L0.8830.49
20_Q108_H0.8790.48
28_V141_V0.8760.48
73_L78_S0.8730.48
133_S141_V0.8670.47
40_W140_V0.8580.47
77_V80_G0.8570.47
59_L131_V0.8560.47
114_N136_C0.8480.46
19_H94_T0.8380.45
7_V22_L0.8370.45
145_D153_R0.8360.45
143_R150_I0.8260.44
19_H33_S0.8250.44
1_E84_E0.8240.44
2_Y150_I0.8170.44
78_S132_V0.8060.43
43_V137_A0.8030.42
22_L34_S0.8020.42
43_V83_S0.8010.42
57_R145_D0.7990.42
16_F84_E0.7970.42
101_A107_L0.7960.42
2_Y23_Q0.7900.41
74_T83_S0.7830.41
91_A117_T0.7820.41
106_S109_D0.7780.40
108_H115_R0.7780.40
131_V149_Q0.7750.40
106_S114_N0.7690.40
75_P78_S0.7670.40
123_V129_W0.7660.40
110_S123_V0.7640.39
35_G41_E0.7630.39
88_E91_A0.7500.38
110_S116_V0.7490.38
77_V151_Y0.7430.38
85_P91_A0.7380.37
110_S115_R0.7320.37
82_L85_P0.7310.37
106_S117_T0.7300.37
112_L118_P0.7280.37
87_V91_A0.7280.37
2_Y106_S0.7260.37
85_P90_N0.7240.36
43_V75_P0.7110.35
22_L139_P0.7100.35
2_Y104_D0.7090.35
2_Y115_R0.7090.35
16_F87_V0.7030.35
124_Y129_W0.6980.35
20_Q25_R0.6920.34
108_H113_L0.6890.34
103_W114_N0.6890.34
7_V18_L0.6850.34
3_V28_V0.6820.33
115_R123_V0.6810.33
11_S74_T0.6770.33
43_V66_K0.6760.33
137_A150_I0.6730.33
121_E124_Y0.6720.33
26_I67_I0.6710.33
1_E15_V0.6670.32
20_Q115_R0.6580.32
26_I78_S0.6540.31
112_L115_R0.6530.31
58_L122_R0.6520.31
60_D65_G0.6450.31
79_L93_G0.6320.30
115_R133_S0.6270.30
21_G106_S0.6270.30
15_V120_N0.6260.30
74_T81_L0.6250.29
50_H55_P0.6220.29
21_G115_R0.6210.29
41_E132_V0.6200.29
137_A152_S0.6190.29
69_D77_V0.6160.29
104_D123_V0.6120.29
87_V92_D0.6110.29
84_E87_V0.6100.29
35_G154_D0.6080.28
36_D68_P0.6050.28
16_F137_A0.6040.28
87_V90_N0.6030.28
51_V139_P0.6000.28
76_D148_V0.5950.28
24_R110_S0.5950.28
77_V93_G0.5920.27
25_R57_R0.5900.27
7_V20_Q0.5900.27
12_D141_V0.5890.27
56_V146_I0.5860.27
78_S82_L0.5860.27
91_A142_F0.5800.27
11_S49_T0.5800.27
2_Y11_S0.5770.26
6_E133_S0.5750.26
51_V131_V0.5750.26
36_D102_S0.5720.26
30_L93_G0.5710.26
52_R149_Q0.5700.26
12_D147_C0.5640.26
43_V76_D0.5550.25
74_T78_S0.5520.25
40_W153_R0.5460.25
22_L77_V0.5450.24
7_V16_F0.5410.24
99_A102_S0.5400.24
19_H102_S0.5380.24
120_N137_A0.5350.24
25_R53_V0.5350.24
12_D150_I0.5300.24
140_V150_I0.5280.23
13_L43_V0.5250.23
7_V19_H0.5240.23
66_K109_D0.5220.23
70_S118_P0.5170.23
31_T131_V0.5140.23
21_G153_R0.5130.23
29_T33_S0.5110.23
7_V108_H0.5080.22
56_V150_I0.5060.22
133_S140_V0.5030.22
37_Q93_G0.5010.22
131_V134_E0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jcwA 2 0.3742 3.2 0.958 Contact Map
3e8vA 1 0.3484 3 0.959 Contact Map
2qngA 1 0.4 3 0.959 Contact Map
1vtze 8 0.529 1.8 0.963 Contact Map
3nrfA 3 0.3097 1.7 0.964 Contact Map
4whiA 1 0.4581 1.6 0.964 Contact Map
1s55A 3 0.3355 1.5 0.965 Contact Map
2k5lA 1 0.2258 1.5 0.965 Contact Map
2xspA 1 0.7935 1.4 0.966 Contact Map
2e9xD 1 0.3548 1.3 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0065 seconds.