GREMLIN Database
GTP_CH_N - GTP cyclohydrolase N terminal
PFAM: PF12471 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 193 (189)
Sequences: 1685 (760)
Seq/√Len: 55.3
META: 0.81

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_G177_E5.8031.00
25_D28_E5.0601.00
139_A144_R4.2021.00
145_L152_L3.6971.00
111_A115_A3.4121.00
132_D158_D3.0851.00
34_G46_V3.0351.00
147_P152_L3.0041.00
105_L109_V2.9941.00
23_A28_E2.9281.00
140_I147_P2.9091.00
155_N158_D2.5931.00
147_P157_G2.5581.00
24_A91_S2.4001.00
113_E118_Y2.2921.00
138_E142_A2.2651.00
20_H28_E2.2341.00
32_V46_V2.2181.00
43_H118_Y2.1351.00
182_S185_D2.1241.00
112_D116_A2.1191.00
91_S102_W2.0971.00
188_R192_E2.0571.00
106_V114_I2.0461.00
27_A113_E2.0231.00
92_D95_K1.8931.00
97_V174_G1.8570.99
23_A102_W1.8410.99
132_D137_R1.8380.99
13_G16_P1.8040.99
113_E116_A1.7850.99
83_P105_L1.7540.99
36_V49_T1.6860.99
40_N43_H1.6440.99
131_I164_A1.5650.98
22_G92_D1.5110.98
35_T73_P1.5050.98
149_G154_E1.5000.97
63_A71_H1.4810.97
158_D162_T1.4620.97
36_V41_P1.4490.97
51_S71_H1.4310.97
61_A179_F1.4130.96
152_L159_V1.4080.96
114_I118_Y1.3620.96
34_G55_S1.3430.95
143_G146_K1.3390.95
62_V67_L1.2840.94
2_H8_H1.2670.93
88_P91_S1.2610.93
130_H160_R1.2540.93
112_D115_A1.2520.93
49_T55_S1.2240.92
138_E141_A1.1990.91
2_H7_S1.1960.91
82_V128_K1.1940.91
104_H113_E1.1920.91
133_L160_R1.1910.91
56_V70_D1.1830.91
153_L160_R1.1780.91
17_F118_Y1.1700.90
83_P126_V1.1540.90
25_D102_W1.1530.90
133_L139_A1.1310.89
17_F113_E1.1310.89
130_H164_A1.1150.88
96_I99_L1.1120.88
46_V73_P1.1060.88
79_A108_E1.1020.87
181_V185_D1.1000.87
12_G16_P1.0880.87
35_T119_D1.0800.86
189_A193_Q1.0770.86
41_P46_V1.0740.86
159_V167_E1.0730.86
64_A140_I1.0700.86
68_D71_H1.0500.85
19_I32_V1.0420.84
51_S185_D1.0410.84
23_A26_P1.0390.84
137_R141_A1.0270.83
20_H23_A1.0210.83
105_L108_E1.0180.83
59_A190_L1.0120.83
35_T50_H1.0120.83
4_R10_G1.0070.82
82_V162_T0.9950.81
54_Y129_A0.9920.81
50_H64_A0.9430.78
106_V109_V0.9420.78
16_P43_H0.9400.78
167_E175_V0.9380.77
81_A104_H0.9370.77
99_L124_I0.9360.77
132_D155_N0.9260.77
146_K152_L0.9250.77
104_H118_Y0.9230.76
4_R73_P0.9200.76
24_A88_P0.9170.76
51_S167_E0.9160.76
39_T50_H0.9090.75
34_G56_V0.9060.75
146_K154_E0.9050.75
119_D128_K0.9010.75
183_E187_R0.8980.74
85_G89_Q0.8900.74
25_D109_V0.8860.73
26_P109_V0.8820.73
17_F33_I0.8820.73
150_K160_R0.8800.73
43_H131_I0.8800.73
150_K158_D0.8660.72
171_Y175_V0.8610.71
87_H102_W0.8510.70
51_S63_A0.8410.69
141_A157_G0.8410.69
70_D107_A0.8380.69
41_P55_S0.8380.69
51_S83_P0.8350.69
22_G91_S0.8270.68
114_I191_F0.8250.68
95_K153_L0.8230.68
55_S188_R0.8170.67
42_A62_V0.8160.67
128_K162_T0.8110.67
33_I39_T0.8110.67
138_E143_G0.8070.66
153_L189_A0.8040.66
24_A28_E0.8030.66
61_A128_K0.8020.66
186_L190_L0.8010.66
76_T96_I0.8000.66
27_A112_D0.7990.65
65_G117_G0.7970.65
102_W109_V0.7970.65
80_P104_H0.7940.65
67_L80_P0.7900.65
12_G17_F0.7880.64
35_T42_A0.7820.64
145_L154_E0.7790.63
67_L76_T0.7770.63
2_H14_K0.7770.63
137_R157_G0.7650.62
49_T71_H0.7650.62
187_R190_L0.7560.61
74_D98_S0.7560.61
133_L151_I0.7460.60
36_V39_T0.7450.60
34_G131_I0.7410.60
49_T87_H0.7370.59
4_R193_Q0.7330.59
11_Q15_G0.7310.59
20_H56_V0.7300.58
99_L166_I0.7280.58
16_P33_I0.7240.58
83_P108_E0.7220.58
111_A116_A0.7190.57
87_H151_I0.7180.57
126_V159_V0.7170.57
73_P87_H0.7100.56
62_V157_G0.7080.56
118_Y167_E0.7040.56
153_L158_D0.6980.55
183_E186_L0.6900.54
4_R136_I0.6850.54
110_F171_Y0.6840.54
11_Q14_K0.6830.53
12_G23_A0.6820.53
27_A110_F0.6810.53
147_P150_K0.6800.53
95_K146_K0.6770.53
68_D128_K0.6740.52
177_E182_S0.6670.52
61_A67_L0.6650.51
36_V193_Q0.6630.51
82_V132_D0.6630.51
22_G94_G0.6610.51
113_E120_I0.6510.50
133_L138_E0.6490.50
8_H36_V0.6450.49
185_D189_A0.6390.49
64_A159_V0.6380.49
7_S16_P0.6370.48
49_T128_K0.6350.48
17_F26_P0.6350.48
84_I126_V0.6320.48
34_G50_H0.6290.48
46_V158_D0.6290.48
137_R142_A0.6290.48
7_S19_I0.6270.47
16_P167_E0.6260.47
171_Y174_G0.6240.47
49_T179_F0.6240.47
132_D152_L0.6230.47
81_A181_V0.6200.47
138_E144_R0.6200.47
53_S114_I0.6180.46
131_I134_P0.6170.46
43_H73_P0.6130.46
150_K153_L0.6110.46
44_R117_G0.6100.46
4_R16_P0.6090.45
99_L167_E0.6080.45
32_V72_R0.6060.45
44_R60_L0.6030.45
60_L186_L0.6030.45
85_G121_R0.5990.44
86_P102_W0.5990.44
120_I177_E0.5960.44
33_I118_Y0.5960.44
81_A167_E0.5930.44
166_I180_G0.5930.44
171_Y177_E0.5920.44
138_E153_L0.5910.44
13_G18_P0.5880.43
50_H123_T0.5880.43
27_A109_V0.5870.43
35_T121_R0.5860.43
136_I159_V0.5820.43
75_L107_A0.5820.43
11_Q53_S0.5810.42
79_A133_L0.5810.42
61_A193_Q0.5800.42
104_H114_I0.5750.42
104_H147_P0.5740.42
33_I42_A0.5730.42
61_A131_I0.5730.42
133_L153_L0.5720.42
9_P61_A0.5700.41
55_S72_R0.5690.41
18_P166_I0.5680.41
79_A111_A0.5670.41
60_L71_H0.5650.41
7_S49_T0.5650.41
56_V104_H0.5650.41
70_D175_V0.5640.41
64_A99_L0.5610.40
58_R62_V0.5610.40
62_V113_E0.5600.40
4_R65_G0.5590.40
62_V118_Y0.5580.40
49_T70_D0.5560.40
134_P137_R0.5550.40
154_E177_E0.5520.39
187_R191_F0.5520.39
58_R117_G0.5490.39
115_A138_E0.5490.39
2_H55_S0.5470.39
133_L136_I0.5430.39
112_D155_N0.5430.39
73_P121_R0.5420.38
24_A155_N0.5420.38
88_P95_K0.5410.38
140_I152_L0.5390.38
131_I159_V0.5380.38
147_P155_N0.5360.38
79_A83_P0.5340.38
76_T79_A0.5340.38
19_I46_V0.5330.38
17_F63_A0.5330.38
16_P34_G0.5320.37
77_N116_A0.5290.37
89_Q121_R0.5250.37
24_A72_R0.5240.37
10_G14_K0.5240.37
64_A181_V0.5220.36
153_L159_V0.5220.36
79_A123_T0.5190.36
19_I95_K0.5180.36
69_P193_Q0.5170.36
123_T134_P0.5140.36
29_R32_V0.5130.36
118_Y146_K0.5120.35
104_H160_R0.5120.35
64_A121_R0.5120.35
81_A105_L0.5110.35
145_L155_N0.5110.35
98_S179_F0.5070.35
27_A77_N0.5060.35
175_V179_F0.5060.35
16_P118_Y0.5050.35
130_H153_L0.5040.35
22_G74_D0.5020.34
20_H32_V0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ra5A 2 0.0052 77.4 0.952 Contact Map
2ek5A 4 0.2591 63.8 0.957 Contact Map
3ihuA 1 0.2487 60.9 0.958 Contact Map
4tv7A 2 0.3057 58.5 0.958 Contact Map
3eetA 2 0.2746 56.5 0.959 Contact Map
2hs5A 1 0.2539 56.3 0.959 Contact Map
3neuA 2 0.2953 54.8 0.959 Contact Map
4u0wA 2 0.3057 50 0.96 Contact Map
1u8bA 1 0.5389 49.7 0.96 Contact Map
2b0lA 4 0.3316 43.5 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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