GREMLIN Database
DUF3686 - ATPase involved in DNA repair
PFAM: PF12458 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 447 (446)
Sequences: 1008 (681)
Seq/√Len: 32.2
META: 0.652

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
255_L264_V5.5191.00
336_S384_F5.3351.00
210_T216_S5.2071.00
202_I255_L5.1431.00
256_V267_I5.0851.00
221_D248_R4.7571.00
256_V283_I4.5051.00
204_V257_F4.2481.00
308_F311_R3.8811.00
124_A140_W3.8711.00
34_N59_K3.7091.00
178_V206_N3.6101.00
243_K254_Y3.5731.00
185_I231_I3.5601.00
188_L235_R3.5561.00
258_N290_Y3.5061.00
190_R259_T3.4331.00
232_A252_W3.3101.00
418_V442_I3.3021.00
191_V257_F3.0981.00
1_E4_R2.9691.00
183_P196_V2.9601.00
173_T176_D2.8801.00
152_D155_G2.8381.00
245_R252_W2.8181.00
195_T200_L2.7901.00
202_I242_L2.7481.00
193_V244_I2.6741.00
182_H196_V2.6041.00
232_A243_K2.5971.00
284_I344_V2.5631.00
34_N56_I2.5391.00
123_L137_V2.5341.00
190_R235_R2.4791.00
49_L70_L2.4791.00
166_D276_L2.4710.99
99_D150_Y2.4580.99
203_K213_G2.4360.99
53_N104_Y2.4130.99
61_E101_A2.3790.99
321_L334_L2.3780.99
186_S190_R2.3770.99
172_T231_I2.3080.99
269_A287_G2.2650.99
121_K141_L2.2390.99
195_T242_L2.2050.99
113_L127_Q2.1960.99
98_R102_E2.1680.99
137_V159_I2.1600.99
177_H185_I2.1280.98
172_T233_Y2.0830.98
116_R159_I2.0690.98
408_L411_G2.0270.98
171_R230_E1.9990.98
307_E327_R1.9670.97
56_I62_T1.9000.97
12_A15_E1.9000.97
212_E216_S1.8950.97
177_H227_D1.8780.97
11_A15_E1.8680.96
112_L115_L1.8640.96
306_L333_L1.8380.96
7_E11_A1.8290.96
34_N54_V1.8000.96
199_D216_S1.7880.95
172_T176_D1.7600.95
161_F327_R1.7540.95
196_V231_I1.7490.95
245_R250_E1.7170.94
200_L242_L1.7150.94
270_I274_C1.7080.94
348_I363_V1.7070.94
265_V296_Y1.7050.94
281_H339_L1.7020.94
1_E5_R1.6480.93
342_K417_S1.6370.93
290_Y296_Y1.6320.93
181_R209_E1.6050.92
243_K252_W1.5930.92
3_R419_A1.5640.91
230_E252_W1.5630.91
143_S149_T1.5410.90
196_V210_T1.5390.90
23_E381_Q1.5370.90
194_E199_D1.5310.90
127_Q131_R1.5250.90
306_L326_N1.5240.90
55_F59_K1.5200.90
188_L240_I1.5170.89
176_D188_L1.5120.89
72_R82_E1.5050.89
172_T185_I1.5000.89
437_K441_R1.4880.89
188_L233_Y1.4510.87
56_I59_K1.4440.87
121_K151_I1.4440.87
117_R142_I1.4360.87
237_G280_D1.4290.86
374_V414_E1.4270.86
114_Q309_E1.3990.85
260_K434_D1.3930.85
55_F209_E1.3790.84
46_D72_R1.3780.84
218_P222_P1.3550.83
16_V401_Y1.3520.83
273_A286_P1.3490.83
355_L361_L1.3490.83
24_L27_T1.3480.83
201_T213_G1.3320.82
230_E245_R1.3150.81
70_L90_L1.3140.81
114_Q161_F1.3130.81
207_N211_G1.3120.81
140_W247_Y1.3100.81
123_L357_D1.3090.81
191_V210_T1.3070.81
254_Y271_G1.3020.81
150_Y153_N1.2960.80
415_C442_I1.2940.80
357_D386_S1.2830.80
176_D233_Y1.2790.80
125_V135_I1.2780.79
44_V305_G1.2730.79
92_D97_V1.2640.79
188_L236_V1.2590.78
139_R158_D1.2500.78
123_L159_I1.2490.78
195_T202_I1.2470.78
236_V276_L1.2450.78
390_A394_P1.2440.78
25_I381_Q1.2410.77
190_R240_I1.2330.77
41_I348_I1.2260.77
128_I156_E1.2180.76
47_R69_S1.2170.76
125_V159_I1.2170.76
137_V156_E1.2140.76
417_S438_A1.2000.75
142_I148_V1.1930.75
49_L146_G1.1810.74
54_V58_L1.1560.72
386_S391_A1.1560.72
287_G298_T1.1510.72
195_T206_N1.1410.71
139_R155_G1.1380.71
314_S373_R1.1330.71
236_V241_L1.1330.71
314_S412_I1.1310.70
75_E360_T1.1300.70
110_T293_T1.1300.70
35_N61_E1.1280.70
414_E446_Y1.1180.70
208_T213_G1.1170.70
76_D79_F1.1060.69
393_Q397_D1.1010.68
203_K208_T1.0980.68
105_R247_Y1.0900.68
3_R7_E1.0870.67
235_R240_I1.0870.67
426_D439_C1.0860.67
155_G158_D1.0850.67
171_R306_L1.0850.67
125_V161_F1.0800.67
184_H203_K1.0740.66
204_V207_N1.0740.66
374_V417_S1.0720.66
171_R232_A1.0710.66
26_G447_H1.0700.66
194_E207_N1.0700.66
349_I407_D1.0670.66
91_L331_R1.0660.66
273_A324_F1.0620.66
187_I242_L1.0580.65
279_E377_M1.0490.65
202_I264_V1.0460.64
245_R415_C1.0450.64
126_F140_W1.0450.64
34_N207_N1.0440.64
424_K431_L1.0360.64
20_T314_S1.0300.63
256_V270_I1.0290.63
320_V339_L1.0280.63
182_H203_K1.0270.63
57_G214_I1.0220.63
182_H213_G1.0180.62
123_L158_D1.0170.62
67_V104_Y1.0160.62
215_Y255_L1.0160.62
141_L308_F1.0120.62
84_L88_L1.0010.61
163_P168_E0.9980.61
152_D406_A0.9950.60
408_L412_I0.9920.60
118_I283_I0.9900.60
175_E353_Y0.9850.60
418_V439_C0.9850.60
20_T385_V0.9800.59
412_I421_L0.9720.59
421_L431_L0.9680.58
74_E80_E0.9680.58
70_L91_L0.9630.58
35_N58_L0.9620.58
427_P434_D0.9610.58
97_V101_A0.9610.58
199_D233_Y0.9550.57
186_S192_F0.9520.57
399_F403_I0.9510.57
105_R354_S0.9510.57
191_V312_I0.9420.56
166_D322_Y0.9410.56
181_R225_S0.9410.56
203_K207_N0.9360.56
184_H192_F0.9320.55
191_V258_N0.9200.54
25_I376_P0.9190.54
273_A406_A0.9180.54
41_I48_L0.9140.54
48_L372_T0.9050.53
191_V242_L0.9050.53
393_Q396_G0.9020.53
396_G401_Y0.9000.53
155_G406_A0.8960.52
323_V334_L0.8950.52
142_I153_N0.8950.52
361_L389_F0.8940.52
273_A293_T0.8910.52
26_G108_K0.8910.52
38_P190_R0.8900.52
16_V397_D0.8850.52
184_H213_G0.8850.52
199_D215_Y0.8850.52
210_T213_G0.8840.51
158_D441_R0.8830.51
43_A354_S0.8790.51
184_H214_I0.8780.51
259_T262_Q0.8760.51
195_T201_T0.8760.51
270_I283_I0.8680.50
387_D392_A0.8660.50
56_I60_K0.8660.50
170_T187_I0.8660.50
286_P333_L0.8640.50
104_Y110_T0.8640.50
303_L326_N0.8590.49
194_E213_G0.8570.49
436_V440_T0.8560.49
21_E299_F0.8560.49
236_V323_V0.8560.49
139_R152_D0.8520.49
34_N55_F0.8520.49
95_R153_N0.8510.49
303_L306_L0.8500.49
351_H368_E0.8490.49
123_L139_R0.8490.49
114_Q342_K0.8480.48
109_D130_E0.8460.48
161_F307_E0.8450.48
5_R64_V0.8430.48
97_V244_I0.8410.48
99_D234_A0.8410.48
79_F84_L0.8400.48
428_Y431_L0.8370.48
64_V377_M0.8360.47
110_T357_D0.8320.47
220_D250_E0.8320.47
5_R9_L0.8310.47
305_G328_E0.8300.47
412_I428_Y0.8300.47
54_V207_N0.8290.47
99_D153_N0.8270.47
414_E419_A0.8270.47
321_L355_L0.8230.46
75_E407_D0.8220.46
79_F85_P0.8220.46
39_R42_V0.8220.46
141_L149_T0.8210.46
128_I361_L0.8200.46
69_S411_G0.8200.46
153_N174_R0.8180.46
427_P431_L0.8180.46
213_G219_V0.8160.46
297_K445_S0.8160.46
335_L365_R0.8150.46
176_D306_L0.8140.46
81_L85_P0.8130.46
103_L126_F0.8080.45
144_D377_M0.8080.45
2_L10_N0.8080.45
260_K436_V0.8080.45
232_A254_Y0.8010.45
296_Y439_C0.7990.44
67_V100_F0.7990.44
425_E431_L0.7980.44
91_L218_P0.7970.44
237_G257_F0.7950.44
247_Y384_F0.7930.44
240_I371_P0.7910.44
200_L330_G0.7860.43
128_I136_K0.7810.43
23_E76_D0.7800.43
123_L156_E0.7800.43
218_P423_N0.7790.43
202_I261_T0.7740.42
18_G40_D0.7720.42
35_N59_K0.7710.42
281_H422_I0.7700.42
422_I432_Y0.7670.42
286_P399_F0.7670.42
143_S147_L0.7670.42
405_N409_V0.7660.42
256_V265_V0.7650.42
113_L283_I0.7640.42
103_L138_F0.7620.41
239_L264_V0.7620.41
43_A46_D0.7600.41
73_F360_T0.7590.41
139_R428_Y0.7580.41
227_D402_K0.7550.41
205_E213_G0.7510.41
194_E211_G0.7490.40
154_R378_Q0.7490.40
271_G286_P0.7480.40
136_K247_Y0.7450.40
272_Q279_E0.7440.40
261_T314_S0.7410.40
116_R137_V0.7410.40
174_R227_D0.7400.40
28_E38_P0.7370.39
192_F213_G0.7350.39
192_F203_K0.7310.39
62_T280_D0.7310.39
173_T196_V0.7300.39
16_V410_R0.7300.39
121_K158_D0.7300.39
56_I207_N0.7290.39
231_I293_T0.7290.39
89_S92_D0.7260.39
39_R325_Y0.7260.39
374_V441_R0.7260.39
199_D202_I0.7250.39
229_A256_V0.7230.38
267_I384_F0.7230.38
215_Y264_V0.7230.38
68_F308_F0.7220.38
69_S423_N0.7220.38
374_V413_S0.7210.38
42_V122_L0.7210.38
115_L124_A0.7200.38
20_T206_N0.7200.38
293_T342_K0.7190.38
47_R72_R0.7170.38
27_T309_E0.7170.38
158_D374_V0.7160.38
113_L325_Y0.7150.38
363_V408_L0.7150.38
195_T213_G0.7150.38
196_V199_D0.7130.38
428_Y443_L0.7130.38
16_V71_Y0.7120.38
53_N58_L0.7080.37
28_E43_A0.7070.37
384_F445_S0.7060.37
197_G206_N0.7060.37
102_E108_K0.7060.37
2_L9_L0.7050.37
293_T336_S0.7040.37
129_G268_D0.7030.37
43_A73_F0.7020.37
149_T343_E0.7000.37
403_I447_H0.6990.37
203_K229_A0.6990.37
133_D247_Y0.6980.36
184_H340_I0.6980.36
275_V292_Q0.6980.36
201_T219_V0.6980.36
367_E372_T0.6960.36
350_C365_R0.6960.36
231_I236_V0.6960.36
167_F194_E0.6950.36
286_P305_G0.6940.36
411_G447_H0.6930.36
4_R7_E0.6910.36
391_A394_P0.6890.36
300_D389_F0.6870.36
279_E297_K0.6840.35
204_V211_G0.6840.35
336_S411_G0.6840.35
27_T43_A0.6830.35
232_A362_V0.6830.35
167_F279_E0.6820.35
26_G308_F0.6810.35
260_K429_A0.6790.35
2_L13_R0.6780.35
364_F377_M0.6770.35
178_V342_K0.6750.35
419_A423_N0.6740.35
2_L5_R0.6720.35
314_S407_D0.6710.34
145_D247_Y0.6700.34
367_E411_G0.6670.34
55_F62_T0.6670.34
197_G216_S0.6660.34
31_R372_T0.6660.34
434_D446_Y0.6660.34
138_F333_L0.6630.34
199_D207_N0.6620.34
13_R17_F0.6620.34
173_T361_L0.6620.34
195_T296_Y0.6600.34
115_L158_D0.6590.34
124_A166_D0.6580.33
9_L13_R0.6580.33
136_K142_I0.6580.33
105_R170_T0.6550.33
141_L407_D0.6550.33
412_I446_Y0.6530.33
103_L107_Y0.6530.33
127_Q132_A0.6520.33
163_P245_R0.6510.33
194_E233_Y0.6510.33
23_E245_R0.6500.33
116_R195_T0.6500.33
389_F396_G0.6500.33
273_A307_E0.6500.33
303_L403_I0.6490.33
119_G161_F0.6460.33
248_R275_V0.6460.33
8_A310_R0.6450.33
64_V190_R0.6450.33
422_I439_C0.6430.32
95_R99_D0.6410.32
200_L217_E0.6400.32
113_L175_E0.6400.32
341_R345_A0.6390.32
238_N292_Q0.6380.32
279_E360_T0.6380.32
91_L313_R0.6370.32
138_F275_V0.6360.32
76_D187_I0.6360.32
204_V421_L0.6330.32
387_D394_P0.6330.32
368_E371_P0.6320.32
269_A298_T0.6320.32
194_E201_T0.6310.32
374_V446_Y0.6310.32
65_S308_F0.6310.32
192_F207_N0.6300.31
279_E410_R0.6300.31
199_D213_G0.6290.31
107_Y153_N0.6290.31
200_L239_L0.6280.31
21_E273_A0.6280.31
111_R127_Q0.6270.31
424_K427_P0.6270.31
121_K244_I0.6250.31
426_D431_L0.6230.31
404_G409_V0.6210.31
119_G368_E0.6210.31
28_E73_F0.6200.31
99_D325_Y0.6200.31
189_D233_Y0.6190.31
54_V59_K0.6180.31
202_I341_R0.6180.31
206_N411_G0.6180.31
10_N13_R0.6170.31
440_T443_L0.6150.30
39_R113_L0.6150.30
152_D315_P0.6140.30
29_R104_Y0.6120.30
297_K440_T0.6110.30
362_V447_H0.6100.30
170_T418_V0.6100.30
326_N329_S0.6090.30
165_H177_H0.6090.30
191_V231_I0.6080.30
261_T290_Y0.6080.30
421_L428_Y0.6080.30
4_R76_D0.6070.30
99_D156_E0.6070.30
62_T104_Y0.6060.30
263_E348_I0.6060.30
62_T255_L0.6060.30
414_E441_R0.6060.30
153_N156_E0.6060.30
438_A441_R0.6040.30
53_N68_F0.6040.30
95_R98_R0.6030.30
426_D430_G0.6030.30
44_V142_I0.6030.30
235_R259_T0.6030.30
163_P241_L0.6020.29
77_D80_E0.6010.29
111_R362_V0.6010.29
163_P355_L0.6010.29
421_L425_E0.6000.29
203_K257_F0.6000.29
25_I377_M0.5990.29
53_N192_F0.5990.29
108_K364_F0.5990.29
408_L420_R0.5980.29
109_D421_L0.5980.29
295_E435_L0.5960.29
300_D321_L0.5950.29
172_T306_L0.5950.29
94_P418_V0.5940.29
14_K43_A0.5930.29
124_A157_R0.5920.29
47_R273_A0.5920.29
276_L281_H0.5900.29
203_K210_T0.5900.29
398_S402_K0.5890.29
360_T381_Q0.5880.29
175_E267_I0.5880.29
386_S389_F0.5870.28
200_L255_L0.5870.28
107_Y189_D0.5870.28
355_L400_L0.5860.28
185_I232_A0.5860.28
267_I290_Y0.5860.28
227_D424_K0.5850.28
116_R123_L0.5850.28
126_F181_R0.5840.28
58_L207_N0.5830.28
365_R403_I0.5820.28
353_Y358_D0.5810.28
163_P209_E0.5800.28
36_C40_D0.5800.28
320_V408_L0.5790.28
436_V439_C0.5780.28
45_G312_I0.5780.28
140_W248_R0.5780.28
314_S390_A0.5780.28
6_A46_D0.5770.28
46_D279_E0.5770.28
173_T232_A0.5760.28
145_D149_T0.5760.28
436_V447_H0.5760.28
28_E350_C0.5750.28
238_N306_L0.5740.28
284_I333_L0.5730.28
440_T447_H0.5710.27
227_D372_T0.5710.27
333_L344_V0.5690.27
182_H242_L0.5690.27
430_G446_Y0.5680.27
73_F105_R0.5670.27
114_Q159_I0.5670.27
95_R281_H0.5670.27
30_I339_L0.5610.27
386_S394_P0.5600.27
236_V267_I0.5600.27
159_I344_V0.5590.27
239_L320_V0.5580.27
262_Q407_D0.5570.27
4_R8_A0.5570.27
432_Y435_L0.5570.27
166_D279_E0.5560.26
250_E322_Y0.5550.26
106_Y347_P0.5550.26
227_D436_V0.5540.26
59_K207_N0.5540.26
168_E286_P0.5540.26
308_F324_F0.5540.26
227_D247_Y0.5530.26
302_D442_I0.5520.26
260_K433_E0.5510.26
276_L292_Q0.5500.26
96_F100_F0.5500.26
109_D354_S0.5490.26
165_H324_F0.5490.26
338_N347_P0.5490.26
275_V325_Y0.5480.26
386_S390_A0.5470.26
186_S194_E0.5470.26
36_C54_V0.5470.26
356_F365_R0.5460.26
25_I171_R0.5460.26
192_F208_T0.5450.26
59_K243_K0.5440.26
101_A108_K0.5440.26
87_D161_F0.5430.26
377_M408_L0.5430.26
407_D414_E0.5420.26
320_V403_I0.5410.25
155_G320_V0.5410.25
240_I287_G0.5410.25
13_R18_G0.5400.25
213_G229_A0.5400.25
201_T215_Y0.5390.25
83_P89_S0.5380.25
175_E197_G0.5380.25
106_Y338_N0.5370.25
38_P71_Y0.5370.25
250_E445_S0.5370.25
6_A216_S0.5370.25
21_E353_Y0.5360.25
178_V373_R0.5360.25
307_E354_S0.5360.25
428_Y435_L0.5360.25
361_L400_L0.5360.25
100_F324_F0.5350.25
238_N259_T0.5350.25
124_A221_D0.5350.25
137_V153_N0.5350.25
417_S435_L0.5340.25
423_N442_I0.5340.25
242_L357_D0.5330.25
316_N338_N0.5330.25
35_N192_F0.5330.25
50_F104_Y0.5330.25
37_V104_Y0.5330.25
99_D104_Y0.5320.25
108_K432_Y0.5310.25
174_R177_H0.5310.25
184_H208_T0.5310.25
63_K135_I0.5310.25
30_I310_R0.5300.25
56_I422_I0.5300.25
172_T293_T0.5280.25
196_V365_R0.5280.25
105_R245_R0.5270.25
329_S447_H0.5270.25
227_D434_D0.5260.25
172_T196_V0.5250.25
104_Y432_Y0.5250.25
412_I419_A0.5250.25
54_V57_G0.5240.24
379_I445_S0.5240.24
70_L124_A0.5230.24
52_Y68_F0.5230.24
44_V141_L0.5220.24
88_L92_D0.5190.24
259_T283_I0.5190.24
265_V290_Y0.5190.24
193_V219_V0.5190.24
39_R330_G0.5180.24
384_F408_L0.5180.24
35_N56_I0.5180.24
242_L257_F0.5160.24
132_A185_I0.5160.24
188_L372_T0.5150.24
79_F82_E0.5150.24
104_Y211_G0.5140.24
279_E354_S0.5140.24
402_K445_S0.5140.24
25_I371_P0.5120.24
158_D414_E0.5120.24
389_F423_N0.5110.24
30_I60_K0.5110.24
287_G390_A0.5110.24
144_D206_N0.5100.24
289_Y297_K0.5100.24
281_H293_T0.5100.24
25_I236_V0.5090.24
70_L88_L0.5090.24
37_V74_E0.5090.24
53_N247_Y0.5080.23
176_D189_D0.5070.23
16_V398_S0.5070.23
25_I335_L0.5060.23
8_A202_I0.5050.23
270_I386_S0.5050.23
186_S223_D0.5040.23
214_I257_F0.5040.23
125_V128_I0.5020.23
48_L274_C0.5020.23
312_I353_Y0.5010.23
166_D225_S0.5000.23
79_F83_P0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bo9A 2 0.1544 39 0.984 Contact Map
2gjlA 2 0.1521 28.3 0.985 Contact Map
3ahnA 1 0.1588 21.7 0.986 Contact Map
1c9oA 2 0.1477 13.1 0.987 Contact Map
2lxjA 1 0.1477 10.2 0.988 Contact Map
4immA 1 0.689 8.5 0.988 Contact Map
3s9jA 1 0.349 8.4 0.988 Contact Map
1z84A 2 0.4183 7.9 0.988 Contact Map
1ykdA 2 0.4251 7.4 0.989 Contact Map
4yzsA 3 0.4586 7.4 0.989 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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