GREMLIN Database
DUF3683 - Protein of unknown function (DUF3683)
PFAM: PF12447 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 113 (112)
Sequences: 2531 (803)
Seq/√Len: 75.8
META: 0.922

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_E97_K3.5231.00
22_L58_Q3.3001.00
107_A111_R3.2291.00
27_A104_A3.0741.00
89_E106_R3.0641.00
26_E100_E2.9291.00
80_A83_H2.9081.00
27_A30_L2.6931.00
87_E90_K2.6541.00
29_E32_E2.4301.00
82_R110_D2.3621.00
92_R99_G2.3001.00
82_R106_R2.1011.00
16_R20_I2.0061.00
75_R79_E1.9371.00
110_D113_E1.8981.00
65_D69_D1.8171.00
14_S17_E1.7801.00
86_D106_R1.6761.00
22_L54_I1.6581.00
26_E29_E1.6531.00
82_R113_E1.6411.00
98_V102_L1.6371.00
29_E33_E1.4790.99
25_E29_E1.4380.99
50_V109_V1.4190.99
37_E97_K1.4170.99
74_R78_I1.4130.99
100_E104_A1.3730.98
85_L109_V1.3720.98
28_W35_R1.3180.98
50_V105_A1.3000.98
74_R81_L1.2970.98
58_Q111_R1.2930.98
30_L97_K1.2690.97
31_L42_R1.2350.97
79_E86_D1.2330.97
51_L55_W1.2230.97
54_I108_A1.1890.96
103_A107_A1.1790.96
53_D80_A1.1600.96
49_E84_R1.1460.95
19_V28_W1.1460.95
18_I55_W1.1330.95
105_A109_V1.0890.94
97_K100_E1.0470.92
87_E98_V1.0190.91
20_I27_A0.9970.91
30_L104_A0.9900.90
86_D89_E0.9890.90
89_E92_R0.9750.90
23_L51_L0.9690.89
107_A110_D0.9690.89
26_E104_A0.9510.88
104_A107_A0.9440.88
100_E103_A0.9360.88
4_R7_P0.9360.88
13_F64_Q0.9240.87
77_L80_A0.9140.86
42_R48_Y0.9090.86
53_D76_A0.8910.85
100_E107_A0.8870.85
94_R99_G0.8870.85
79_E82_R0.8820.84
71_P75_R0.8770.84
30_L100_E0.8470.82
87_E92_R0.8450.82
14_S49_E0.8360.81
106_R110_D0.8340.81
42_R81_L0.8260.80
82_R86_D0.8080.79
70_N80_A0.8030.78
78_I82_R0.7980.78
45_R63_L0.7970.78
86_D90_K0.7890.77
46_M55_W0.7890.77
25_E32_E0.7880.77
18_I53_D0.7760.76
70_N81_L0.7670.75
45_R83_H0.7610.74
39_R64_Q0.7590.74
105_A110_D0.7570.74
22_L27_A0.7570.74
99_G103_A0.7540.74
85_L102_L0.7480.73
77_L112_F0.7470.73
89_E103_A0.7390.72
95_D99_G0.7360.72
96_A107_A0.7300.71
88_I92_R0.7280.71
23_L55_W0.7180.70
89_E102_L0.7170.70
54_I57_V0.7160.70
26_E30_L0.7130.69
76_A80_A0.7120.69
64_Q78_I0.7090.69
85_L92_R0.7020.68
77_L81_L0.6970.68
88_I102_L0.6940.67
89_E99_G0.6850.66
32_E48_Y0.6850.66
76_A79_E0.6840.66
42_R85_L0.6830.66
53_D70_N0.6810.66
22_L48_Y0.6800.66
88_I105_A0.6790.66
48_Y95_D0.6740.65
17_E21_R0.6720.65
42_R54_I0.6700.65
66_D81_L0.6670.64
64_Q80_A0.6590.63
13_F49_E0.6560.63
9_N12_S0.6440.62
92_R98_V0.6430.61
35_R44_A0.6350.60
42_R65_D0.6330.60
62_Y87_E0.6320.60
35_R56_V0.6290.60
12_S15_D0.6220.59
21_R84_R0.6220.59
57_V66_D0.6190.59
71_P74_R0.6180.58
96_A110_D0.6130.58
68_L74_R0.6110.58
42_R45_R0.6110.58
37_E88_I0.6080.57
30_L39_R0.6060.57
63_L76_A0.6050.57
38_R44_A0.6000.56
102_L106_R0.5980.56
77_L83_H0.5980.56
37_E95_D0.5950.56
6_I9_N0.5910.55
46_M64_Q0.5850.54
49_E66_D0.5830.54
55_W84_R0.5820.54
58_Q76_A0.5800.54
5_E35_R0.5780.53
41_G59_R0.5770.53
75_R113_E0.5740.53
40_T43_S0.5710.53
27_A31_L0.5680.52
31_L47_L0.5680.52
13_F17_E0.5650.52
96_A99_G0.5610.51
19_V31_L0.5590.51
82_R89_E0.5540.50
57_V81_L0.5510.50
49_E105_A0.5490.50
93_E96_A0.5480.50
8_Y53_D0.5470.50
78_I113_E0.5440.49
40_T44_A0.5410.49
17_E84_R0.5410.49
17_E49_E0.5380.48
67_L74_R0.5340.48
81_L91_R0.5330.48
88_I98_V0.5320.48
103_A110_D0.5310.48
49_E57_V0.5230.47
10_Y47_L0.5200.46
19_V27_A0.5180.46
29_E94_R0.5160.46
41_G60_N0.5140.45
13_F84_R0.5130.45
5_E38_R0.5080.45
4_R9_N0.5060.44
83_H87_E0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dndA 1 0.6018 20.6 0.942 Contact Map
2y1nA 1 0.7168 14.8 0.945 Contact Map
2c5kT 1 0.6549 13.1 0.947 Contact Map
4j2cA 1 0.6726 11.3 0.948 Contact Map
3u0rA 1 0.8673 8.5 0.951 Contact Map
1jqnA 3 0.9469 6.8 0.953 Contact Map
4pz1A 2 0.292 6.6 0.953 Contact Map
2zaeA 1 0.5221 5.9 0.954 Contact Map
4r8aA 1 0.8319 5.8 0.954 Contact Map
3l4jA 1 0.9823 5.1 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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