GREMLIN Database
MAGE_N - Melanoma associated antigen family N terminal
PFAM: PF12440 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 94 (93)
Sequences: 959 (737)
Seq/√Len: 76.4
META: 0.002

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_R13_R3.3451.00
3_Q8_R2.7461.00
2_G5_S2.4371.00
5_S8_R2.2671.00
13_R17_R2.1261.00
5_S13_R2.0921.00
6_K12_K2.0531.00
59_T63_P2.0191.00
25_G49_Q1.9211.00
1_R13_R1.8281.00
65_G74_A1.7951.00
6_K9_A1.7421.00
4_K9_A1.7241.00
33_E60_P1.7021.00
61_Q91_E1.6811.00
3_Q87_S1.5780.99
8_R13_R1.5660.99
61_Q66_A1.5480.99
89_E93_P1.5430.99
83_E87_S1.4960.99
45_G59_T1.4810.99
43_L48_P1.4660.99
3_Q7_L1.4420.99
34_E42_P1.4230.99
1_R10_R1.3610.98
2_G9_A1.3600.98
6_K10_R1.3480.98
6_K17_R1.3410.98
7_L11_E1.3130.98
2_G8_R1.3120.98
72_A79_S1.2970.98
9_A12_K1.2720.98
1_R8_R1.2590.97
68_S93_P1.2520.97
35_E93_P1.2500.97
51_S85_A1.2450.97
2_G10_R1.2350.97
61_Q89_E1.2170.97
82_D91_E1.2150.97
83_E93_P1.2140.97
76_V83_E1.2140.97
1_R6_K1.1990.96
49_Q69_T1.1960.96
10_R21_Q1.1930.96
49_Q83_E1.1660.96
23_L76_V1.1520.96
11_E82_D1.0850.94
37_P43_L1.0760.94
11_E14_R1.0760.94
81_S91_E1.0120.91
65_G68_S0.9870.90
72_A81_S0.9700.89
11_E16_A0.9660.89
44_S60_P0.9560.89
78_C92_S0.9520.89
22_G39_S0.9400.88
83_E86_S0.9400.88
6_K13_R0.9260.87
4_K11_E0.9230.87
32_E40_S0.9220.87
82_D88_Q0.9140.86
82_D93_P0.9030.86
8_R17_R0.8860.85
63_P82_D0.8690.84
46_G54_A0.8620.83
44_S48_P0.8550.83
9_A13_R0.8410.81
5_S10_R0.8400.81
62_S65_G0.8370.81
83_E91_E0.8290.81
5_S9_A0.8230.80
37_P85_A0.8220.80
26_A31_A0.8180.80
29_T36_S0.8150.79
42_P75_A0.7800.76
80_R92_S0.7800.76
56_T77_S0.7650.75
22_G27_Q0.7630.75
7_L16_A0.7580.74
69_T72_A0.7400.73
21_Q37_P0.7340.72
29_T32_E0.7300.71
39_S44_S0.7300.71
2_G6_K0.7230.71
74_A77_S0.7150.70
69_T74_A0.7140.70
45_G91_E0.7110.69
83_E89_E0.7080.69
19_E32_E0.7080.69
6_K30_A0.7050.69
78_C83_E0.7050.69
42_P60_P0.7020.69
69_T88_Q0.7010.68
86_S90_E0.6990.68
72_A86_S0.6930.68
21_Q59_T0.6860.67
25_G30_A0.6820.66
9_A17_R0.6780.66
16_A55_G0.6730.65
48_P70_T0.6730.65
16_A53_A0.6720.65
41_S93_P0.6640.64
2_G13_R0.6640.64
50_S56_T0.6530.63
20_T23_L0.6460.62
27_Q33_E0.6430.62
38_S41_S0.6420.62
1_R12_K0.6360.61
77_S81_S0.6280.60
26_A57_P0.6270.60
47_T80_R0.6260.60
46_G52_P0.6250.60
5_S14_R0.6060.57
2_G11_E0.6020.57
20_T38_S0.5990.56
49_Q75_A0.5900.55
70_T79_S0.5820.54
79_S82_D0.5820.54
1_R4_K0.5790.54
18_G24_E0.5750.53
53_A68_S0.5660.52
25_G57_P0.5660.52
19_E64_Q0.5660.52
12_K52_P0.5650.52
32_E84_G0.5610.52
45_G78_C0.5590.51
44_S80_R0.5520.50
20_T28_A0.5430.49
42_P48_P0.5310.48
29_T66_A0.5300.48
34_E47_T0.5190.46
2_G7_L0.5180.46
33_E92_S0.5130.46
46_G66_A0.5090.45
48_P61_Q0.5090.45
5_S36_S0.5070.45
60_P64_Q0.5050.44
30_A38_S0.5030.44
58_S64_Q0.5000.44
65_G80_R0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wgsA 1 0.383 1.5 0.921 Contact Map
4gnkB 1 0.5106 1.3 0.924 Contact Map
5a2fA 1 0 1.1 0.927 Contact Map
3quvA 2 0.2234 1 0.93 Contact Map
1onvB 1 0.2234 0.8 0.934 Contact Map
1zxgA 1 0.3298 0.7 0.936 Contact Map
3mi9C 1 0.0106 0.7 0.937 Contact Map
2y96A 3 0.2128 0.7 0.937 Contact Map
3qwoC 1 0.2979 0.7 0.937 Contact Map
4npdA 1 0.3191 0.6 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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