GREMLIN Database
DUF3671 - Protein of unknown function
PFAM: PF12420 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 102 (102)
Sequences: 585 (413)
Seq/√Len: 40.9
META: 0.009

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_K17_D4.9231.00
93_Y97_K3.2431.00
18_K21_K3.1621.00
80_F83_L2.9061.00
20_D23_Y2.5091.00
2_K5_K2.1440.99
93_Y101_Y2.0230.99
79_F83_L1.9560.99
95_L98_V1.9410.99
3_G7_L1.9200.99
81_F84_I1.8640.98
89_L94_I1.7240.97
99_I102_E1.7150.97
17_D28_K1.7090.97
88_L96_I1.5970.96
58_G64_L1.5290.94
24_K27_E1.5240.94
68_T71_I1.5170.94
97_K101_Y1.5030.94
55_P62_P1.4650.93
66_K70_E1.4150.92
36_F41_L1.3820.91
69_W88_L1.3640.90
11_C14_K1.3440.90
12_E16_F1.3440.90
65_N82_I1.3360.89
65_N68_T1.3010.88
67_D70_E1.2950.88
37_K45_G1.2750.87
5_K24_K1.2710.87
6_K10_Y1.2590.86
35_S39_K1.2280.85
72_I76_N1.2200.84
78_I84_I1.2160.84
83_L87_V1.2060.84
38_K74_Y1.1870.83
63_I75_L1.1810.82
61_F73_E1.1660.82
57_L62_P1.1250.79
6_K9_C1.1220.79
21_K36_F1.1130.78
51_F62_P1.1100.78
82_I90_V1.0890.77
28_K35_S1.0780.76
68_T95_L1.0770.76
59_L77_Y1.0650.75
51_F55_P1.0620.75
27_E34_K1.0570.75
73_E77_Y1.0370.73
72_I77_Y1.0370.73
25_L48_L1.0170.72
67_D82_I1.0160.72
37_K94_I0.9950.70
19_I50_L0.9900.70
48_L54_I0.9900.70
48_L81_F0.9560.67
22_I38_K0.9490.66
16_F20_D0.9440.66
8_D24_K0.9410.66
20_D56_L0.9410.66
19_I74_Y0.9280.65
1_K7_L0.9270.65
8_D21_K0.8960.62
46_I50_L0.8940.62
5_K21_K0.8850.61
53_L62_P0.8850.61
46_I55_P0.8810.61
49_I63_I0.8810.61
5_K30_K0.8780.60
33_K61_F0.8780.60
15_I20_D0.8780.60
56_L67_D0.8700.60
37_K41_L0.8640.59
4_L30_K0.8560.58
52_S91_I0.8550.58
38_K99_I0.8510.58
74_Y77_Y0.8440.57
82_I85_I0.8370.57
20_D47_R0.7970.53
67_D71_I0.7890.52
93_Y100_K0.7780.51
68_T77_Y0.7770.51
81_F86_I0.7750.51
30_K36_F0.7730.51
69_W72_I0.7720.51
66_K69_W0.7720.51
72_I82_I0.7710.51
28_K91_I0.7680.50
62_P73_E0.7650.50
34_K60_I0.7580.49
76_N84_I0.7540.49
17_D23_Y0.7540.49
71_I82_I0.7510.49
61_F83_L0.7460.48
10_Y86_I0.7450.48
51_F58_G0.7390.48
32_D35_S0.7260.46
8_D97_K0.7250.46
22_I31_N0.7180.46
26_A40_I0.7080.45
7_L63_I0.7000.44
32_D75_L0.6980.44
63_I80_F0.6810.42
13_K23_Y0.6810.42
2_K44_Y0.6810.42
18_K60_I0.6690.41
18_K32_D0.6640.41
69_W73_E0.6610.41
74_Y78_I0.6610.41
42_K56_L0.6590.40
2_K9_C0.6590.40
19_I27_E0.6540.40
7_L11_C0.6510.40
3_G55_P0.6490.39
78_I82_I0.6490.39
29_M90_V0.6420.39
24_K80_F0.6420.39
45_G56_L0.6390.39
59_L83_L0.6340.38
84_I91_I0.6320.38
23_Y30_K0.6210.37
80_F84_I0.6200.37
47_R58_G0.6200.37
58_G62_P0.6180.37
33_K38_K0.6160.37
26_A93_Y0.6150.37
48_L95_L0.6130.36
21_K41_L0.6090.36
61_F75_L0.5990.35
29_M91_I0.5940.35
3_G9_C0.5890.34
21_K24_K0.5850.34
71_I86_I0.5840.34
19_I71_I0.5800.34
30_K50_L0.5790.33
21_K44_Y0.5740.33
45_G94_I0.5720.33
31_N59_L0.5710.33
8_D32_D0.5700.33
91_I98_V0.5670.32
67_D73_E0.5660.32
14_K44_Y0.5650.32
45_G53_L0.5530.31
84_I94_I0.5450.31
24_K91_I0.5330.30
19_I24_K0.5290.29
27_E86_I0.5280.29
68_T72_I0.5210.29
5_K86_I0.5200.29
9_C53_L0.5050.28
15_I34_K0.5040.28
74_Y88_L0.5030.28
31_N98_V0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fftB 1 0.4118 2.8 0.928 Contact Map
3k4tA 3 0.2059 1.6 0.937 Contact Map
4ng0A 1 0.3235 1.4 0.939 Contact Map
2l6wA 2 0.3824 1.3 0.94 Contact Map
1jb0I 1 0.3725 1.2 0.942 Contact Map
2m8rA 1 0.6078 1.1 0.943 Contact Map
4bgnA 3 0.549 1.1 0.943 Contact Map
4ev6A 3 0.902 1 0.944 Contact Map
4xk8I 1 0.2843 1 0.944 Contact Map
3j39b 1 0.2549 1 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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