GREMLIN Database
DUF3670 - SNF2 Helicase protein
PFAM: PF12419 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 136 (130)
Sequences: 9326 (6422)
Seq/√Len: 563.2
META: 0.867

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_E80_P5.2351.00
83_E87_E4.2831.00
9_T12_E3.4581.00
107_D110_E3.2511.00
112_R116_A2.9331.00
15_R19_E2.8161.00
86_L90_A2.3681.00
42_P50_V2.1321.00
14_Y18_R2.0341.00
82_T85_E2.0011.00
79_E102_Q1.9841.00
74_L86_L1.9651.00
70_F75_A1.9561.00
77_G102_Q1.8351.00
83_E119_E1.7501.00
18_R105_E1.7501.00
63_G66_A1.7391.00
85_E100_R1.6561.00
126_L131_A1.6451.00
16_F24_L1.6441.00
19_E24_L1.6231.00
128_F132_L1.6191.00
47_R73_E1.6141.00
119_E122_E1.5241.00
127_S130_E1.5171.00
79_E100_R1.5151.00
19_E23_L1.4911.00
38_R41_R1.4791.00
109_E112_R1.4311.00
75_A78_D1.4041.00
126_L134_L1.3981.00
69_D125_G1.3871.00
62_L67_L1.3581.00
116_A119_E1.3251.00
114_A118_L1.3121.00
24_L29_F1.2611.00
38_R42_P1.2571.00
87_E91_A1.2541.00
116_A120_K1.2471.00
110_E113_R1.2431.00
84_E88_A1.2431.00
87_E119_E1.2401.00
108_P112_R1.2291.00
117_F121_V1.2121.00
129_A133_R1.1911.00
40_R48_L1.1541.00
11_E94_R1.1501.00
21_A31_V1.1361.00
44_L50_V1.1331.00
45_G48_L1.1321.00
99_L104_V1.1231.00
121_V124_G1.1071.00
88_A91_A1.1071.00
113_R116_A1.1041.00
51_K69_D1.0951.00
88_A92_A1.0901.00
42_P49_G1.0771.00
10_P94_R1.0591.00
71_D122_E1.0551.00
64_L67_L1.0531.00
13_A103_W1.0481.00
13_A16_F1.0481.00
44_L48_L1.0471.00
90_A93_K1.0301.00
94_R108_P1.0301.00
17_L37_W1.0271.00
114_A117_F1.0121.00
125_G128_F1.0101.00
21_A33_L1.0051.00
49_G53_P0.9891.00
66_A69_D0.9851.00
83_E122_E0.9841.00
39_R49_G0.9821.00
14_Y105_E0.9781.00
45_G50_V0.9581.00
109_E113_R0.9501.00
49_G52_S0.9441.00
42_P46_V0.9401.00
35_A100_R0.9341.00
62_L66_A0.9271.00
40_R44_L0.9251.00
72_W86_L0.9221.00
6_L12_E0.9211.00
15_R20_A0.9201.00
92_A95_P0.9101.00
35_A102_Q0.8991.00
49_G73_E0.8961.00
81_L86_L0.8911.00
33_L114_A0.8881.00
84_E87_E0.8871.00
14_Y95_P0.8841.00
85_E88_A0.8731.00
42_P48_L0.8571.00
8_L12_E0.8541.00
39_R42_P0.8501.00
38_R49_G0.8471.00
50_V53_P0.8461.00
89_L99_L0.8391.00
120_K124_G0.8171.00
92_A97_V0.8131.00
106_V111_L0.8091.00
18_R22_P0.7901.00
17_L36_W0.7821.00
98_R101_G0.7811.00
64_L129_A0.7781.00
50_V131_A0.7751.00
23_L26_A0.7671.00
39_R44_L0.7651.00
87_E90_A0.7571.00
77_G80_P0.7441.00
16_F31_V0.7401.00
21_A25_E0.7291.00
70_F86_L0.7291.00
56_A59_P0.7241.00
128_F134_L0.7221.00
39_R43_R0.7131.00
48_L51_K0.7131.00
115_L119_E0.7041.00
22_P26_A0.7021.00
130_E133_R0.7021.00
46_V72_W0.6981.00
64_L68_L0.6961.00
43_R47_R0.6901.00
21_A24_L0.6831.00
118_L121_V0.6811.00
90_A94_R0.6731.00
33_L36_W0.6731.00
40_R46_V0.6721.00
12_E15_R0.6681.00
61_G66_A0.6671.00
35_A114_A0.6591.00
51_K71_D0.6471.00
8_L13_A0.6451.00
95_P105_E0.6401.00
67_L70_F0.6391.00
113_R117_F0.6351.00
86_L92_A0.6331.00
13_A36_W0.6321.00
19_E22_P0.6291.00
40_R50_V0.6201.00
75_A80_P0.6171.00
24_L31_V0.6161.00
122_E125_G0.6091.00
81_L89_L0.6091.00
47_R50_V0.6061.00
60_S63_G0.6041.00
3_P8_L0.6031.00
73_E83_E0.5991.00
53_P60_S0.5971.00
49_G71_D0.5951.00
38_R44_L0.5881.00
4_H7_A0.5841.00
72_W75_A0.5831.00
127_S131_A0.5740.99
6_L107_D0.5730.99
10_P14_Y0.5720.99
11_E15_R0.5670.99
117_F120_K0.5650.99
37_W68_L0.5650.99
112_R115_L0.5600.99
62_L73_E0.5510.99
30_G105_E0.5500.99
39_R45_G0.5490.99
94_R98_R0.5480.99
128_F131_A0.5470.99
81_L99_L0.5460.99
14_Y36_W0.5450.99
53_P56_A0.5420.99
96_L103_W0.5410.99
95_P106_V0.5380.99
86_L111_L0.5370.99
75_A86_L0.5350.99
41_R45_G0.5290.99
95_P103_W0.5270.99
67_L75_A0.5260.99
51_K56_A0.5230.99
37_W86_L0.5220.99
15_R18_R0.5220.99
86_L106_V0.5210.99
9_T13_A0.5200.99
110_E115_L0.5200.99
39_R53_P0.5180.99
41_R110_E0.5170.99
43_R50_V0.5150.99
22_P25_E0.5090.99
110_E114_A0.5090.99
37_W128_F0.5080.99
32_R99_L0.5080.99
93_K101_G0.5080.99
33_L96_L0.5070.99
82_T88_A0.5050.99
42_P53_P0.5040.99
38_R46_V0.5020.99
39_R46_V0.5020.99
36_W105_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ncvA 2 0.8162 63.7 0.871 Contact Map
3kdgA 2 0.8382 50.6 0.881 Contact Map
1x9zA 4 0.8676 29.7 0.895 Contact Map
2z51A 2 0.9338 21.8 0.902 Contact Map
2vlaA 1 0.8309 20.6 0.903 Contact Map
2jq5A 1 0.7059 14.5 0.909 Contact Map
2pvbA 1 0.4412 11.6 0.913 Contact Map
4e4wB 1 0.8382 10.5 0.915 Contact Map
4uzxA 1 0.3971 9.7 0.916 Contact Map
3nyvA 1 0.8382 9.6 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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