GREMLIN Database
Choline_sulf_C - Choline sulfatase enzyme C terminal
PFAM: PF12411 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 53 (52)
Sequences: 2817 (1287)
Seq/√Len: 178.4
META: 0.922

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_R36_R4.3081.00
28_Q33_A2.8861.00
14_Y18_R2.0241.00
45_N48_E1.9751.00
27_Y30_L1.8061.00
18_R22_Y1.7481.00
8_R11_R1.7191.00
35_R41_H1.7011.00
29_P33_A1.6201.00
24_P34_S1.6101.00
46_D50_R1.6041.00
44_L48_E1.5241.00
32_D35_R1.3681.00
38_V48_E1.3371.00
16_A20_G1.2211.00
6_S9_R1.2141.00
2_D5_A1.1991.00
5_A9_R1.1951.00
38_V47_L1.1051.00
9_R51_A1.0771.00
43_D46_D1.0591.00
13_V16_A1.0541.00
22_Y40_N1.0361.00
15_A19_Q1.0341.00
38_V45_N1.0300.99
40_N44_L1.0130.99
46_D49_A0.9680.99
28_Q31_R0.9660.99
4_L8_R0.9500.99
45_N49_A0.9480.99
17_L20_G0.9450.99
38_V41_H0.9440.99
17_L23_T0.9420.99
14_Y38_V0.9400.99
12_L16_A0.9220.99
38_V42_M0.9140.99
44_L51_A0.9080.99
50_R53_F0.8750.98
44_L47_L0.8670.98
47_L50_R0.8340.98
14_Y40_N0.8290.98
48_E51_A0.8270.98
42_M47_L0.8200.97
42_M50_R0.7990.97
11_R15_A0.7910.97
4_L11_R0.7900.97
19_Q23_T0.7700.96
13_V17_L0.7680.96
9_R48_E0.7360.95
17_L24_P0.7190.95
27_Y31_R0.7190.95
47_L53_F0.7150.94
49_A53_F0.7150.94
18_R21_R0.7090.94
33_A36_R0.6890.93
23_T30_L0.6770.93
8_R12_L0.6630.92
43_D48_E0.6350.90
15_A21_R0.6280.90
19_Q22_Y0.6240.89
47_L51_A0.6110.88
29_P39_R0.6000.87
41_H44_L0.5940.87
48_E52_R0.5940.87
33_A37_Y0.5780.85
43_D47_L0.5720.85
4_L12_L0.5700.85
35_R42_M0.5670.84
42_M45_N0.5550.83
28_Q32_D0.5470.82
18_R42_M0.5430.82
10_R25_W0.5370.81
28_Q37_Y0.5340.81
30_L35_R0.5290.80
6_S25_W0.5280.80
26_D33_A0.5190.79
19_Q36_R0.5090.77
31_R38_V0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kkxA 1 0.2075 4.7 0.876 Contact Map
4hu4A 1 0.7736 4.6 0.876 Contact Map
4hjfA 1 0.8302 4.5 0.876 Contact Map
4rnhA 2 0.8679 4.4 0.877 Contact Map
3rx6A 2 0.8113 4.1 0.879 Contact Map
3hv8A 1 0.7358 3.9 0.881 Contact Map
2r6oA 2 0.7736 3.6 0.882 Contact Map
2basA 2 0.7358 3.1 0.886 Contact Map
3pjxA 1 0.8302 3.1 0.886 Contact Map
4fojA 1 0.8302 3.1 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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