GREMLIN Database
P5-ATPase - P5-type ATPase cation transporter
PFAM: PF12409 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 125 (125)
Sequences: 908 (627)
Seq/√Len: 56.1
META: 0.162

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_D66_E4.3411.00
23_G31_L4.2021.00
47_C57_W3.1631.00
10_Y16_R2.5471.00
43_V57_W2.4251.00
88_E91_N2.3371.00
55_A113_R2.1751.00
22_A26_L2.0801.00
12_T17_L2.0711.00
116_D121_R2.0341.00
33_L41_W2.0191.00
87_P90_E1.9911.00
77_Y83_T1.9661.00
9_G52_L1.9321.00
33_L37_W1.8941.00
52_L72_V1.8881.00
35_F39_P1.8761.00
104_D108_E1.8490.99
20_Y35_F1.8190.99
20_Y118_R1.8030.99
94_S97_I1.7810.99
20_Y24_C1.7530.99
24_C32_L1.7160.99
43_V47_C1.7120.99
22_A25_I1.5800.98
20_Y23_G1.5470.98
104_D107_P1.5360.98
92_G96_S1.5100.98
72_V113_R1.5050.98
89_P92_G1.4980.98
79_R83_T1.4580.97
11_R54_E1.3840.96
33_L39_P1.3660.96
27_T31_L1.3650.96
84_V109_L1.2900.94
36_Y124_W1.2790.94
17_L30_L1.2770.94
52_L57_W1.2690.94
92_G98_A1.2200.92
22_A73_R1.2200.92
10_Y32_L1.1700.91
36_Y119_Y1.1670.91
98_A102_D1.1600.90
88_E92_G1.1500.90
70_K117_Y1.1420.90
50_C55_A1.1420.90
94_S98_A1.1330.89
62_D114_Y1.1310.89
92_G103_E1.1280.89
22_A60_I1.1100.88
96_S100_A1.1020.88
43_V64_F1.0950.88
18_A21_L1.0940.87
13_S17_L1.0570.86
13_S48_K1.0480.85
97_I103_E1.0210.84
45_A57_W1.0090.83
30_L34_L1.0080.83
20_Y42_R0.9900.82
26_L112_L0.9860.81
22_A102_D0.9860.81
88_E94_S0.9760.81
7_I16_R0.9700.80
20_Y45_A0.9670.80
13_S16_R0.9520.79
89_P93_D0.9520.79
113_R124_W0.9470.79
86_P89_P0.9460.79
31_L35_F0.9420.78
24_C118_R0.9200.77
96_S103_E0.9180.77
96_S99_N0.9090.76
32_L119_Y0.9080.76
35_F69_V0.9080.76
32_L42_R0.9060.76
13_S41_W0.9020.75
87_P91_N0.9000.75
27_T95_S0.8970.75
119_Y124_W0.8870.74
11_R56_D0.8820.74
60_I70_K0.8810.73
34_L38_K0.8810.73
86_P103_E0.8750.73
97_I101_N0.8720.73
36_Y61_E0.8690.72
3_D36_Y0.8640.72
21_L24_C0.8590.72
77_Y82_S0.8570.71
94_S101_N0.8560.71
74_T111_K0.8390.70
88_E93_D0.8370.70
89_P94_S0.8370.70
17_L21_L0.8310.69
11_R120_I0.8280.69
28_L117_Y0.8200.68
92_G97_I0.8160.68
35_F118_R0.8050.67
11_R50_C0.8020.66
100_A103_E0.8010.66
35_F119_Y0.7950.66
2_D6_E0.7850.65
14_R54_E0.7830.64
42_R46_T0.7770.64
46_T124_W0.7760.64
68_F73_R0.7760.64
34_L51_P0.7710.63
43_V65_G0.7690.63
9_G37_W0.7660.63
55_A123_V0.7600.62
9_G39_P0.7560.62
73_R114_Y0.7510.61
14_R18_A0.7500.61
6_E31_L0.7470.61
74_T80_P0.7440.60
67_Y77_Y0.7360.60
93_D96_S0.7340.59
87_P97_I0.7320.59
26_L104_D0.7270.59
96_S102_D0.7190.58
36_Y47_C0.7050.56
114_Y121_R0.7050.56
67_Y117_Y0.6970.55
59_L119_Y0.6920.55
80_P123_V0.6890.55
97_I100_A0.6800.54
28_L31_L0.6790.54
95_S100_A0.6710.53
14_R110_L0.6660.52
80_P84_V0.6620.52
90_E94_S0.6610.52
2_D122_Y0.6500.50
93_D100_A0.6450.50
6_E39_P0.6450.50
21_L31_L0.6380.49
112_L121_R0.6350.49
109_L112_L0.6330.49
38_K44_K0.6290.48
102_D109_L0.6280.48
5_M59_L0.6280.48
55_A115_F0.6230.47
30_L36_Y0.6230.47
72_V111_K0.6200.47
40_R65_G0.6180.47
35_F116_D0.6180.47
37_W55_A0.6170.47
43_V116_D0.6110.46
99_N103_E0.6070.46
18_A25_I0.6070.46
46_T115_F0.5950.44
99_N102_D0.5950.44
1_E52_L0.5950.44
33_L36_Y0.5940.44
72_V91_N0.5920.44
19_L27_T0.5900.44
63_E70_K0.5900.44
8_A61_E0.5850.43
21_L60_I0.5840.43
16_R53_K0.5820.43
44_K110_L0.5800.43
48_K112_L0.5780.43
41_W46_T0.5770.43
4_E55_A0.5670.41
6_E61_E0.5570.40
36_Y41_W0.5570.40
3_D47_C0.5550.40
4_E59_L0.5490.40
88_E96_S0.5440.39
74_T113_R0.5420.39
26_L31_L0.5420.39
32_L124_W0.5410.39
81_L101_N0.5360.38
97_I102_D0.5350.38
43_V118_R0.5340.38
87_P93_D0.5310.38
84_V87_P0.5280.37
11_R55_A0.5280.37
16_R35_F0.5250.37
35_F123_V0.5240.37
20_Y119_Y0.5190.37
22_A28_L0.5180.36
91_N95_S0.5170.36
7_I58_V0.5150.36
61_E112_L0.5140.36
57_W69_V0.5110.36
33_L52_L0.5050.35
78_G85_F0.5040.35
86_P90_E0.5020.35
34_L89_P0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oedE 1 0.28 3.8 0.936 Contact Map
1oedC 1 0.28 3.8 0.936 Contact Map
2hw4A 1 0.312 3.4 0.938 Contact Map
2nmmA 3 0.312 3.2 0.939 Contact Map
2j5lA 1 0 3.2 0.939 Contact Map
2a65A 2 0.56 3 0.939 Contact Map
2xgrA 1 0.464 2.9 0.94 Contact Map
2kogA 1 0.32 2.2 0.944 Contact Map
3rn5A 1 0.28 1.8 0.946 Contact Map
4xtrG 1 0.176 1.8 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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