GREMLIN Database
DUF3663 - Peptidase
PFAM: PF12404 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (77)
Sequences: 637 (388)
Seq/√Len: 44.2
META: 0.476

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_F27_A4.1971.00
63_D66_S3.6111.00
40_I66_S3.3651.00
6_S28_T3.3201.00
21_S30_H2.7231.00
41_Q73_G2.2741.00
48_D76_G2.0260.99
67_Q75_R1.9660.99
12_A16_E1.9190.99
27_A47_L1.9070.99
38_R67_Q1.8920.99
57_L70_F1.8550.99
67_Q71_W1.7050.98
15_G30_H1.6370.97
4_T23_N1.6120.97
55_V70_F1.5300.96
64_L72_Q1.5220.95
71_W77_P1.4850.95
72_Q75_R1.4800.95
15_G18_A1.4260.94
22_F47_L1.3950.93
4_T26_G1.3480.91
58_A61_G1.2750.89
18_A50_Q1.2620.88
35_D38_R1.2300.87
38_R74_F1.2220.87
46_K67_Q1.1980.86
33_G56_S1.1500.83
71_W74_F1.1410.83
19_L39_A1.1080.81
14_W57_L1.0800.79
20_L27_A0.9950.73
48_D75_R0.9900.73
55_V74_F0.9870.73
32_T50_Q0.9850.73
37_L69_A0.9470.70
51_G55_V0.9370.69
1_M64_L0.9230.68
22_F26_G0.8990.65
32_T35_D0.8940.65
10_A21_S0.8870.64
18_A21_S0.8770.64
48_D74_F0.8730.63
1_M14_W0.8690.63
64_L75_R0.8680.63
32_T49_G0.8620.62
15_G21_S0.8570.62
11_D21_S0.8560.62
42_R46_K0.8470.61
29_I44_A0.8390.60
39_A61_G0.8310.59
35_D40_I0.8200.58
10_A20_L0.8180.58
24_E54_Q0.8090.57
23_N39_A0.7860.55
67_Q76_G0.7840.55
66_S73_G0.7820.55
19_L76_G0.7820.55
47_L76_G0.7790.54
20_L30_H0.7670.53
11_D35_D0.7490.52
50_Q75_R0.7470.51
8_Q34_K0.7450.51
61_G66_S0.7440.51
3_V55_V0.7310.50
38_R44_A0.7300.50
29_I36_D0.7240.49
49_G60_E0.6960.46
4_T9_P0.6930.46
29_I40_I0.6830.45
20_L23_N0.6710.44
25_D53_K0.6690.44
42_R71_W0.6690.44
12_A56_S0.6650.43
15_G20_L0.6630.43
30_H57_L0.6570.43
7_T33_G0.6490.42
22_F50_Q0.6430.41
3_V31_L0.6410.41
33_G58_A0.6300.40
46_K64_L0.6260.40
44_A57_L0.6220.39
10_A30_H0.6190.39
49_G54_Q0.6180.39
35_D39_A0.6090.38
2_Q58_A0.6040.38
59_G62_W0.5990.37
50_Q72_Q0.5990.37
14_W18_A0.5940.37
44_A48_D0.5890.36
3_V8_Q0.5880.36
41_Q46_K0.5850.36
49_G58_A0.5820.36
5_L11_D0.5820.36
36_D39_A0.5690.35
17_K32_T0.5680.35
43_A51_G0.5670.35
30_H70_F0.5670.35
36_D44_A0.5590.34
74_F77_P0.5480.33
51_G73_G0.5470.33
2_Q8_Q0.5460.33
32_T58_A0.5450.33
60_E65_E0.5440.33
48_D69_A0.5430.32
7_T36_D0.5350.32
3_V22_F0.5270.31
4_T7_T0.5250.31
24_E28_T0.5230.31
17_K44_A0.5160.30
20_L29_I0.5110.30
18_A59_G0.5110.30
37_L40_I0.5110.30
52_I60_E0.5080.30
3_V12_A0.5070.29
48_D55_V0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fp7A 1 0.5065 14.1 0.909 Contact Map
1lamA 5 0.974 11 0.913 Contact Map
3dxiA 2 0.7922 9.9 0.915 Contact Map
3u1jA 1 0.2468 9.4 0.916 Contact Map
3lkwA 3 0.6883 9.4 0.916 Contact Map
4m9kA 1 0.5584 9.1 0.916 Contact Map
3dbiA 2 1 9 0.916 Contact Map
2ijoA 1 0.5195 7.9 0.919 Contact Map
3h1dA 1 0.8571 7.4 0.919 Contact Map
3ilkA 2 0.7403 7.3 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0052 seconds.