GREMLIN Database
U3snoRNP10 - U3 small nucleolar RNA-associated protein 10
PFAM: PF12397 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 114 (112)
Sequences: 600 (473)
Seq/√Len: 44.7
META: 0.25

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_I106_L4.9461.00
12_G25_S4.4851.00
33_A69_L4.2811.00
106_L110_L3.5691.00
29_L46_L3.0601.00
27_M35_K2.5681.00
25_S28_I2.2881.00
12_G21_L2.2781.00
54_W62_G2.1381.00
97_L100_E2.1291.00
47_M66_L1.9710.99
107_L112_P1.9640.99
56_E91_V1.8250.99
76_L81_L1.8100.99
89_D93_L1.7790.98
85_L90_L1.6590.97
59_L89_D1.6260.97
46_L50_I1.5240.96
105_K112_P1.5040.95
4_R42_V1.4640.95
23_A26_Y1.4400.94
64_L69_L1.4200.94
77_P80_V1.4120.93
51_A80_V1.3890.93
13_L29_L1.3410.91
94_L106_L1.3360.91
14_K24_A1.3270.91
8_V26_Y1.3200.91
2_L23_A1.3190.91
90_L108_L1.3000.90
9_L25_S1.2860.90
76_L90_L1.2500.88
3_L25_S1.2330.88
24_A49_A1.2180.87
76_L91_V1.1690.85
9_L99_K1.1400.83
63_L89_D1.1370.83
33_A68_V1.1330.83
21_L31_V1.1270.82
95_L105_K1.1120.82
67_I99_K1.1080.81
74_E98_S1.0940.80
24_A27_M1.0910.80
5_L38_L1.0820.80
106_L109_G1.0710.79
58_T81_L1.0490.78
2_L42_V1.0430.77
68_V72_T1.0410.77
22_Q26_Y1.0320.76
24_A87_V1.0040.74
69_L91_V0.9950.74
68_V75_Q0.9720.72
50_I69_L0.9630.71
42_V45_A0.9540.71
26_Y53_G0.9530.70
29_L63_L0.9490.70
84_L108_L0.9420.70
28_I85_L0.9300.69
91_V95_L0.9200.68
9_L17_K0.9180.68
2_L74_E0.9170.67
8_V42_V0.9160.67
31_V61_S0.9100.67
56_E104_D0.8970.66
23_A58_T0.8930.65
104_D109_G0.8860.65
4_R54_W0.8840.65
22_Q40_D0.8790.64
9_L32_L0.8760.64
63_L93_L0.8690.63
10_L13_L0.8660.63
27_M31_V0.8630.63
4_R8_V0.8600.62
36_A53_G0.8490.61
63_L70_A0.8440.61
97_L101_Y0.8330.60
29_L36_A0.8270.59
44_D90_L0.8150.58
63_L94_L0.8140.58
50_I60_R0.8100.58
15_S26_Y0.8080.58
5_L50_I0.8050.57
9_L86_K0.8010.57
72_T105_K0.7980.57
29_L107_L0.7850.55
3_L10_L0.7800.55
85_L112_P0.7760.55
31_V34_S0.7680.54
26_Y57_E0.7660.54
47_M50_I0.7600.53
82_K86_K0.7570.53
2_L11_E0.7520.52
16_S36_A0.7450.52
45_A59_L0.7430.51
6_L20_D0.7350.51
34_S63_L0.7340.50
17_K37_T0.7300.50
65_C68_V0.7280.50
28_I36_A0.7250.50
40_D81_L0.7200.49
48_E76_L0.7200.49
56_E60_R0.7140.49
64_L68_V0.7120.48
85_L110_L0.6960.47
61_S88_P0.6910.46
4_R69_L0.6890.46
2_L79_K0.6800.45
92_E99_K0.6780.45
106_L111_L0.6760.45
6_L35_K0.6760.45
40_D73_Q0.6740.45
27_M71_Q0.6730.45
27_M109_G0.6710.44
28_I34_S0.6650.44
4_R38_L0.6650.44
56_E59_L0.6640.44
36_A47_M0.6600.43
76_L83_A0.6560.43
47_M70_A0.6550.43
54_W67_I0.6490.42
78_K107_L0.6480.42
19_P47_M0.6440.42
23_A30_S0.6430.42
22_Q46_L0.6420.42
94_L100_E0.6350.41
16_S54_W0.6310.41
18_V39_S0.6300.41
2_L104_D0.6200.40
13_L25_S0.6180.39
48_E62_G0.6150.39
63_L109_G0.6150.39
57_E94_L0.6140.39
67_I70_A0.6120.39
21_L24_A0.6020.38
84_L105_K0.5960.37
47_M80_V0.5940.37
30_S34_S0.5920.37
70_A103_V0.5910.37
5_L80_V0.5900.37
9_L15_S0.5870.37
23_A27_M0.5740.35
24_A53_G0.5730.35
29_L52_K0.5680.35
38_L49_A0.5670.35
32_L75_Q0.5670.35
62_G108_L0.5620.34
99_K109_G0.5610.34
33_A60_R0.5580.34
14_K69_L0.5580.34
45_A98_S0.5570.34
3_L110_L0.5550.34
64_L97_L0.5550.34
26_Y73_Q0.5530.34
90_L96_E0.5530.34
6_L42_V0.5530.34
51_A54_W0.5510.33
14_K52_K0.5460.33
13_L24_A0.5410.33
5_L12_G0.5400.32
8_V12_G0.5340.32
45_A49_A0.5320.32
49_A112_P0.5130.30
5_L37_T0.5110.30
30_S102_D0.5090.30
2_L80_V0.5070.30
28_I109_G0.5040.29
98_S103_V0.5030.29
18_V76_L0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3opbA 2 0.9912 74.8 0.82 Contact Map
1qgrA 1 0.9825 72.7 0.824 Contact Map
4qmiA 1 0.9912 71.6 0.825 Contact Map
1ibrB 1 0.4561 65.9 0.832 Contact Map
3w3wA 1 0.9474 64.3 0.833 Contact Map
4g3aA 1 0.9825 63.9 0.834 Contact Map
2qk2A 1 0.9912 62.8 0.835 Contact Map
3vwaA 1 0.9561 61.4 0.837 Contact Map
4fddA 1 0.9912 58.8 0.839 Contact Map
2bptA 1 0.9912 58.1 0.84 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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