GREMLIN Database
DUF3659 - Protein of unknown function (DUF3659)
PFAM: PF12396 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 61 (59)
Sequences: 2390 (1338)
Seq/√Len: 174.2
META: 0.631

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_D43_E3.5311.00
16_D20_N3.1151.00
46_D50_N2.6991.00
9_N13_N2.3701.00
13_N24_R2.3041.00
43_E54_R2.0891.00
24_R56_E2.0211.00
23_G53_G1.9791.00
13_N21_V1.8511.00
6_L22_V1.8241.00
43_E51_V1.6801.00
14_V38_V1.6661.00
9_N15_V1.6111.00
29_D32_K1.5851.00
25_L33_L1.5231.00
30_A33_L1.4171.00
39_D45_L1.3421.00
27_E54_R1.2851.00
8_V38_V1.2631.00
2_I57_L1.1811.00
4_E40_E1.1681.00
26_V54_R1.1591.00
7_K37_K1.1451.00
15_V21_V1.1441.00
21_V58_L1.1301.00
37_K47_K1.1251.00
23_G55_A1.1001.00
6_L17_E1.0440.99
14_V44_I1.0180.99
3_L6_L0.9780.99
57_L60_E0.9700.99
38_V44_I0.9610.99
3_L23_G0.9590.99
47_K50_N0.9090.99
6_L16_D0.9070.99
30_A34_A0.8910.98
36_K52_I0.8800.98
21_V51_V0.8340.98
29_D43_E0.8240.97
17_E20_N0.7740.96
8_V14_V0.7670.96
23_G38_V0.7660.96
38_V55_A0.7580.96
10_K47_K0.7420.95
38_V59_P0.7410.95
28_G44_I0.7370.95
23_G57_L0.7250.94
45_L52_I0.7210.94
31_K34_A0.7110.94
40_E43_E0.7050.94
9_N19_G0.7000.93
28_G53_G0.6990.93
45_L50_N0.6930.93
7_K10_K0.6810.92
10_K49_G0.6770.92
26_V56_E0.6480.90
25_L44_I0.6470.90
2_I60_E0.6340.89
51_V55_A0.6340.89
24_R53_G0.6340.89
52_I57_L0.6330.89
24_R27_E0.6280.89
5_G37_K0.6240.89
21_V60_E0.6190.88
18_D48_D0.6160.88
45_L51_V0.6050.87
36_K50_N0.5940.86
22_V55_A0.5870.86
13_N52_I0.5820.85
25_L30_A0.5780.85
5_G20_N0.5730.84
26_V29_D0.5700.84
19_G49_G0.5600.83
48_D57_L0.5580.83
2_I6_L0.5570.83
51_V54_R0.5540.82
48_D52_I0.5500.82
27_E32_K0.5480.82
46_D52_I0.5460.81
8_V45_L0.5320.80
37_K41_D0.5290.79
6_L46_D0.5230.78
35_G49_G0.5210.78
12_G42_G0.5140.77
28_G34_A0.5110.77
35_G44_I0.5080.76
47_K59_P0.5050.76
10_K13_N0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qiwA 2 0.7869 9.8 0.83 Contact Map
3rd7A 2 0.5574 5.9 0.846 Contact Map
4r9zA 2 0.541 4.7 0.853 Contact Map
1c8uA 2 0.5738 4.7 0.853 Contact Map
3bbjA 2 0.8197 4.6 0.854 Contact Map
2v2fA 1 0.2459 4.4 0.856 Contact Map
4h5bA 2 0.9836 4 0.858 Contact Map
3cjyA 2 0.541 3.9 0.858 Contact Map
2grgA 1 0.9672 3 0.867 Contact Map
1xi4A 8 0.8525 2.8 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0046 seconds.