GREMLIN Database
DUF3658 - Protein of unknown function
PFAM: PF12395 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 106 (100)
Sequences: 2418 (1702)
Seq/√Len: 170.2
META: 0.804

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_A39_S3.2191.00
86_E89_A2.9861.00
28_P42_E2.7261.00
88_I95_V2.6681.00
62_R66_E2.5751.00
53_I63_V2.5521.00
49_I80_L2.5501.00
5_R11_E2.4571.00
22_L39_S2.3431.00
50_L92_K2.2291.00
60_A84_L2.1741.00
95_V99_L1.9831.00
25_E39_S1.9591.00
53_I93_L1.9271.00
49_I67_V1.8841.00
65_G69_G1.8711.00
52_F67_V1.8701.00
31_I40_V1.8641.00
54_T58_Q1.8391.00
64_I68_L1.7791.00
52_F66_E1.7201.00
29_L79_F1.6501.00
50_L93_L1.6211.00
26_N39_S1.6031.00
67_V80_L1.5741.00
31_I45_Y1.5531.00
33_E36_K1.4801.00
18_E21_K1.4591.00
58_Q63_V1.4321.00
57_W96_Q1.3741.00
42_E79_F1.3561.00
20_K24_E1.2691.00
64_I81_L1.2601.00
33_E38_V1.2541.00
63_V67_V1.2431.00
31_I44_F1.2341.00
8_T11_E1.2181.00
7_L15_D1.1391.00
21_K25_E1.1301.00
15_D18_E1.1071.00
52_F70_K1.1011.00
22_L25_E1.0961.00
86_E90_A1.0901.00
46_D83_R1.0871.00
48_E71_M1.0671.00
49_I84_L1.0490.99
68_L77_D1.0430.99
40_V44_F1.0170.99
48_E51_K1.0170.99
28_P79_F0.9820.99
82_W86_E0.9790.99
44_F73_I0.9550.99
42_E86_E0.9450.99
88_I93_L0.9420.99
7_L12_F0.9370.99
60_A81_L0.9220.99
62_R65_G0.9200.99
6_P12_F0.9100.98
68_L74_K0.9010.98
10_S13_E0.8980.98
81_L85_K0.8960.98
31_I73_I0.8940.98
32_L37_L0.8930.98
85_K89_A0.8780.98
12_F16_P0.8700.98
47_A51_K0.8460.98
18_E36_K0.8370.97
59_K62_R0.8200.97
3_L6_P0.8050.97
29_L40_V0.7780.96
18_E79_F0.7750.96
20_K23_C0.7660.96
4_A84_L0.7580.95
57_W81_L0.7560.95
64_I84_L0.7550.95
12_F17_D0.7530.95
75_T80_L0.7510.95
87_L92_K0.7270.94
48_E67_V0.7260.94
60_A64_I0.7220.94
50_L87_L0.7130.94
29_L44_F0.6980.93
57_W97_G0.6970.93
85_K99_L0.6960.93
46_D49_I0.6820.92
65_G68_L0.6720.91
54_T63_V0.6570.91
4_A7_L0.6510.90
30_R39_S0.6500.90
13_E17_D0.6490.90
62_R68_L0.6460.90
61_A65_G0.6460.90
9_L14_V0.6440.90
63_V84_L0.6430.90
60_A85_K0.6410.89
5_R8_T0.6400.89
47_A50_L0.6400.89
89_A99_L0.6360.89
19_W45_Y0.6340.89
28_P82_W0.6260.88
87_L93_L0.6230.88
73_I84_L0.6200.88
47_A72_K0.6180.88
64_I67_V0.6150.87
27_A41_P0.6150.87
45_Y79_F0.6140.87
26_N58_Q0.6130.87
83_R86_E0.6110.87
57_W82_W0.6110.87
19_W79_F0.6010.86
67_V71_M0.6000.86
15_D34_G0.5990.86
66_E69_G0.5950.86
13_E16_P0.5920.85
50_L55_A0.5870.85
19_W95_V0.5820.84
71_M81_L0.5790.84
53_I87_L0.5790.84
8_T13_E0.5710.83
82_W85_K0.5680.83
63_V93_L0.5630.82
12_F23_C0.5600.82
14_V17_D0.5600.82
62_R70_K0.5490.81
60_A68_L0.5460.80
73_I77_D0.5460.80
40_V47_A0.5450.80
6_P55_A0.5420.80
11_E15_D0.5410.80
43_D99_L0.5360.79
19_W31_I0.5350.79
17_D20_K0.5350.79
81_L88_I0.5340.79
16_P71_M0.5310.79
9_L16_P0.5300.79
22_L26_N0.5270.78
24_E51_K0.5240.78
24_E65_G0.5230.78
6_P9_L0.5220.77
77_D81_L0.5220.77
29_L65_G0.5180.77
37_L83_R0.5170.77
60_A88_I0.5160.77
16_P20_K0.5150.77
61_A68_L0.5090.76
43_D87_L0.5040.75
29_L75_T0.5010.75
89_A98_D0.5010.75
84_L93_L0.5010.75
57_W63_V0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w7pD 1 0.9811 74.7 0.847 Contact Map
1u5tB 1 0.9906 43.2 0.875 Contact Map
3lvtA 2 0.6698 38 0.879 Contact Map
2hyeC 1 1 35.1 0.881 Contact Map
2gqqA 6 0.6038 34.2 0.882 Contact Map
1hsjA 2 0.9528 34 0.882 Contact Map
3dplC 1 1 33.7 0.882 Contact Map
2p5vA 5 0.6038 32.2 0.883 Contact Map
4ch7A 1 0.5472 30.8 0.885 Contact Map
3i4pA 5 0.566 28.7 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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