GREMLIN Database
DUF3656 - Collagenase
PFAM: PF12392 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 107 (105)
Sequences: 12937 (10400)
Seq/√Len: 1014.9
META: 0.889

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_D75_G2.8631.00
57_E61_R2.6371.00
93_E97_E2.4731.00
26_P75_G2.2951.00
61_R65_G2.1921.00
66_K92_N2.1911.00
72_F103_E2.1871.00
43_A98_A2.1751.00
67_L99_V2.1551.00
30_E78_E2.1291.00
26_P73_E2.0731.00
29_L43_A2.0151.00
28_D76_E1.7891.00
5_S10_D1.7651.00
74_L77_L1.7271.00
29_L74_L1.7141.00
45_D106_R1.7111.00
32_S80_D1.7071.00
32_S40_T1.6841.00
59_R88_V1.6671.00
30_E80_D1.6551.00
71_P103_E1.6161.00
90_E93_E1.6131.00
30_E42_T1.5951.00
67_L74_L1.5531.00
101_A105_A1.5161.00
59_R63_Q1.5111.00
24_K73_E1.4631.00
97_E101_A1.4531.00
59_R62_E1.3951.00
63_Q92_N1.3931.00
35_A49_P1.3911.00
53_R59_R1.3741.00
101_A104_E1.3741.00
56_T59_R1.3381.00
48_E51_R1.2961.00
100_E103_E1.2181.00
32_S42_T1.1851.00
28_D44_T1.1841.00
41_L64_L1.1841.00
57_E79_I1.1741.00
87_P90_E1.1661.00
7_P11_R1.1421.00
65_G74_L1.1361.00
97_E100_E1.1071.00
34_R82_D1.0921.00
34_R37_E1.0841.00
100_E104_E1.0811.00
24_K69_G1.0781.00
33_G47_L1.0771.00
33_G39_L1.0191.00
41_L94_L1.0181.00
60_L91_L1.0181.00
49_P83_G1.0171.00
7_P15_K1.0011.00
25_I45_D0.9751.00
88_V92_N0.9721.00
14_R18_E0.9601.00
63_Q66_K0.9601.00
58_E62_E0.9551.00
39_L47_L0.9521.00
60_L79_I0.9501.00
3_R6_D0.9311.00
52_K55_L0.9181.00
15_K18_E0.9081.00
47_L84_L0.9011.00
29_L41_L0.8981.00
12_A16_S0.8941.00
63_Q88_V0.8891.00
29_L67_L0.8881.00
39_L94_L0.8801.00
13_L16_S0.8781.00
58_E61_R0.8731.00
81_L84_L0.8731.00
55_L59_R0.8711.00
43_A99_V0.8621.00
39_L86_L0.8541.00
49_P84_L0.8421.00
93_E96_R0.8421.00
14_R17_L0.8301.00
34_R80_D0.8291.00
13_L17_L0.8261.00
15_K19_K0.8231.00
29_L98_A0.8181.00
51_R85_F0.8141.00
61_R77_L0.8131.00
25_I71_P0.7981.00
30_E44_T0.7811.00
12_A15_K0.7801.00
31_V39_L0.7571.00
27_V102_L0.7561.00
103_E106_R0.7541.00
86_L90_E0.7501.00
27_V43_A0.7471.00
33_G81_L0.7451.00
53_R56_T0.7421.00
11_R15_K0.7381.00
47_L86_L0.7361.00
10_D14_R0.7331.00
72_F102_L0.7331.00
24_K71_P0.7281.00
5_S14_R0.7261.00
92_N96_R0.7231.00
2_Y13_L0.7201.00
62_E65_G0.7071.00
28_D78_E0.7041.00
31_V60_L0.6791.00
10_D17_L0.6631.00
2_Y7_P0.6561.00
35_A82_D0.6541.00
35_A84_L0.6521.00
67_L70_T0.6471.00
29_L77_L0.6411.00
7_P14_R0.6371.00
16_S19_K0.6371.00
56_T62_E0.6341.00
63_Q91_L0.6301.00
60_L81_L0.6261.00
59_R85_F0.6191.00
70_T99_V0.6161.00
90_E97_E0.6111.00
98_A102_L0.6061.00
72_F99_V0.6041.00
46_E75_G0.6021.00
9_L12_A0.5951.00
50_A54_P0.5941.00
64_L91_L0.5931.00
43_A102_L0.5921.00
98_A101_A0.5901.00
27_V67_L0.5861.00
85_F88_V0.5841.00
32_S37_E0.5801.00
25_I106_R0.5791.00
30_E40_T0.5661.00
7_P13_L0.5621.00
37_E40_T0.5621.00
27_V72_F0.5621.00
65_G77_L0.5601.00
2_Y5_S0.5441.00
31_V41_L0.5421.00
94_L98_A0.5411.00
48_E85_F0.5391.00
43_A67_L0.5351.00
53_R85_F0.5331.00
31_V94_L0.5311.00
62_E88_V0.5291.00
54_P58_E0.5271.00
41_L98_A0.5241.00
33_G37_E0.5241.00
39_L43_A0.5221.00
33_G36_G0.5201.00
35_A47_L0.5161.00
63_Q95_R0.5161.00
27_V74_L0.5151.00
21_P24_K0.5121.00
29_L64_L0.5081.00
10_D13_L0.5041.00
31_V64_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dc1A 2 0.7477 9.5 0.897 Contact Map
2ve7A 1 0.5981 6.2 0.905 Contact Map
1dqnA 2 0.5327 5.7 0.906 Contact Map
1szqA 2 0.9159 5.5 0.907 Contact Map
1ivzA 1 0.8598 4.6 0.911 Contact Map
3cvzA 1 0.9346 4 0.913 Contact Map
4pedA 1 0.4953 3.9 0.914 Contact Map
1m5yA 1 0.514 3.7 0.915 Contact Map
3nvtA 4 0.1495 3.6 0.915 Contact Map
1k8kE 1 0.7944 3 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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