GREMLIN Database
Peptidase_M73 - Camelysin metallo-endopeptidase
PFAM: PF12389 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 196 (189)
Sequences: 1005 (859)
Seq/√Len: 62.5
META: 0.736

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_K76_L3.9251.00
30_D44_D3.6001.00
7_G13_A2.9811.00
45_L78_I2.8291.00
9_G13_A2.7371.00
13_A16_G2.6111.00
107_V110_L2.4971.00
69_T159_H2.4431.00
173_G176_F2.3601.00
14_A24_T2.3081.00
40_A179_D2.2791.00
77_D154_A2.2401.00
9_G12_S2.1851.00
10_V17_A2.0621.00
17_A20_I1.9971.00
12_S17_A1.9941.00
52_T55_V1.8851.00
32_E44_D1.8721.00
122_G125_L1.8571.00
168_D172_A1.7911.00
7_G11_A1.7901.00
57_N75_S1.7731.00
13_A17_A1.7270.99
166_F172_A1.6810.99
91_D96_N1.6730.99
14_A17_A1.6480.99
38_F58_L1.6260.99
19_L22_G1.6230.99
123_T127_D1.6220.99
57_N76_L1.6170.99
108_T111_S1.6010.99
93_L96_N1.5980.99
42_T178_G1.5770.99
43_L76_L1.5770.99
103_K126_S1.5360.99
15_L20_I1.5240.99
8_L11_A1.5110.98
45_L70_L1.4740.98
58_L64_V1.4650.98
78_I189_A1.4620.98
102_G107_V1.4350.98
91_D179_D1.4310.98
176_F179_D1.4180.98
21_G25_F1.4080.97
28_F174_N1.3810.97
5_K9_G1.3650.97
42_T74_G1.3630.97
49_P53_V1.3430.97
111_S114_D1.3380.97
8_L12_S1.3340.97
7_G14_A1.3320.96
49_P52_T1.3250.96
118_G121_Y1.2990.96
6_L9_G1.2860.96
99_N103_K1.2760.95
68_F187_F1.2760.95
91_D94_G1.2700.95
86_S186_T1.2580.95
9_G16_G1.2520.95
102_G108_T1.2330.95
92_A179_D1.2310.95
101_L110_L1.2200.94
170_G173_G1.2190.94
134_D138_N1.2160.94
107_V111_S1.2020.94
102_G110_L1.2020.94
108_T112_N1.1860.93
99_N105_I1.1810.93
170_G174_N1.1630.93
145_L148_S1.1550.92
72_N76_L1.1520.92
90_S94_G1.1460.92
98_T175_T1.1270.91
14_A19_L1.1220.91
166_F169_N1.1220.91
65_Q163_T1.1180.91
56_S69_T1.1100.91
86_S129_K1.1050.91
5_K8_L1.1030.91
59_K62_D1.1020.90
172_A176_F1.0910.90
119_P122_G1.0880.90
169_N172_A1.0850.90
33_T45_L1.0850.90
46_A73_S1.0830.90
36_N46_A1.0830.90
176_F189_A1.0730.89
69_T157_T1.0690.89
170_G176_F1.0630.89
124_T165_T1.0570.89
11_A14_A1.0550.88
7_G10_V1.0520.88
125_L128_L1.0480.88
7_G17_A1.0430.88
16_G20_I1.0430.88
113_A116_G1.0290.87
108_T165_T1.0280.87
181_L185_W1.0250.87
50_T55_V1.0070.86
11_A15_L1.0060.86
88_T184_T1.0010.86
143_S146_A0.9970.85
90_S93_L0.9910.85
144_N147_L0.9880.85
100_D110_L0.9830.85
8_L13_A0.9780.84
95_T98_T0.9720.84
99_N102_G0.9700.84
42_T177_Q0.9680.84
18_S23_G0.9670.84
141_I147_L0.9660.84
65_Q161_R0.9650.84
32_E179_D0.9550.83
16_G19_L0.9530.83
46_A71_K0.9450.82
142_G147_L0.9430.82
12_S15_L0.9430.82
51_L55_V0.9410.82
14_A18_S0.9390.82
50_T53_V0.9190.80
114_D117_T0.9170.80
80_S190_T0.9160.80
30_D34_S0.9140.80
16_G21_G0.9120.80
146_A149_G0.9110.80
96_N99_N0.8980.79
36_N57_N0.8940.79
24_T28_F0.8930.79
46_A68_F0.8910.78
119_P125_L0.8870.78
109_F112_N0.8810.78
23_G31_T0.8810.78
20_I24_T0.8760.77
105_I110_L0.8750.77
116_G121_Y0.8730.77
110_L160_L0.8680.77
105_I108_T0.8670.76
96_N100_D0.8640.76
104_H107_V0.8580.76
91_D95_T0.8500.75
106_K111_S0.8440.74
173_G185_W0.8440.74
133_P137_S0.8420.74
106_K109_F0.8390.74
9_G17_A0.8390.74
46_A81_V0.8380.74
34_S179_D0.8310.73
87_Y91_D0.8290.73
102_G105_I0.8250.73
15_L24_T0.8230.73
118_G122_G0.8230.73
86_S184_T0.8210.72
130_S140_V0.8200.72
106_K112_N0.8170.72
5_K12_S0.8130.72
29_S59_K0.8120.72
45_L189_A0.8120.72
105_I109_F0.8090.71
29_S43_L0.8070.71
103_K107_V0.8040.71
7_G32_E0.8030.71
120_I123_T0.8010.71
142_G148_S0.7990.70
26_A32_E0.7990.70
108_T163_T0.7940.70
14_A20_I0.7920.70
19_L26_A0.7860.69
6_L13_A0.7820.69
134_D137_S0.7790.68
43_L180_S0.7770.68
118_G136_V0.7710.68
98_T101_L0.7690.67
44_D73_S0.7650.67
5_K13_A0.7630.67
106_K165_T0.7620.67
70_L187_F0.7600.67
89_V184_T0.7550.66
122_G126_S0.7540.66
100_D107_V0.7500.65
174_N177_Q0.7490.65
23_G29_S0.7490.65
103_K108_T0.7460.65
109_F114_D0.7430.65
77_D153_T0.7420.65
118_G127_D0.7330.64
124_T128_L0.7290.63
135_L138_N0.7280.63
10_V18_S0.7270.63
99_N107_V0.7270.63
120_I125_L0.7260.63
126_S129_K0.7180.62
88_T152_L0.7150.62
120_I126_S0.7070.61
33_T184_T0.7030.60
22_G26_A0.6930.59
7_G12_S0.6930.59
113_A119_P0.6910.59
97_T175_T0.6880.59
43_L78_I0.6850.58
118_G125_L0.6840.58
10_V21_G0.6830.58
117_T120_I0.6810.58
5_K20_I0.6730.57
70_L78_I0.6700.57
27_Y190_T0.6630.56
24_T32_E0.6600.56
93_L97_T0.6590.56
82_T188_T0.6540.55
114_D122_G0.6540.55
145_L149_G0.6530.55
58_L156_A0.6530.55
111_S116_G0.6520.55
72_N158_D0.6510.55
32_E189_A0.6490.54
109_F115_K0.6450.54
103_K106_K0.6440.54
135_L139_A0.6410.54
7_G16_G0.6390.53
121_Y124_T0.6370.53
90_S97_T0.6350.53
39_A75_S0.6340.53
37_T54_N0.6290.52
113_A118_G0.6220.51
6_L10_V0.6180.51
103_K110_L0.6160.51
117_T123_T0.6150.51
94_G97_T0.6140.50
110_L113_A0.6070.50
122_G127_D0.6060.50
9_G19_L0.6030.49
67_S159_H0.6020.49
154_A193_A0.6010.49
172_A175_T0.6010.49
128_L131_T0.5980.49
45_L187_F0.5980.49
79_A82_T0.5950.48
16_G83_L0.5920.48
93_L99_N0.5900.48
125_L129_K0.5890.48
11_A19_L0.5870.47
94_G100_D0.5850.47
116_G125_L0.5850.47
62_D83_L0.5830.47
62_D66_R0.5820.47
96_N103_K0.5800.47
27_Y178_G0.5800.47
10_V48_G0.5790.46
22_G27_Y0.5760.46
44_D179_D0.5740.46
27_Y45_L0.5730.46
110_L114_D0.5720.46
140_V143_S0.5710.46
97_T103_K0.5690.45
121_Y125_L0.5680.45
116_G122_G0.5640.45
59_K192_R0.5630.45
112_N115_K0.5580.44
45_L170_G0.5560.44
115_K128_L0.5550.44
108_T113_A0.5550.44
147_L150_G0.5530.43
104_H110_L0.5500.43
107_V112_N0.5490.43
49_P81_V0.5440.42
42_T75_S0.5410.42
168_D173_G0.5400.42
8_L14_A0.5360.42
116_G120_I0.5350.41
42_T62_D0.5310.41
164_F168_D0.5280.41
77_D155_G0.5270.41
7_G29_S0.5200.40
79_A130_S0.5180.40
116_G119_P0.5110.39
133_P136_V0.5100.39
56_S146_A0.5100.39
142_G145_L0.5100.39
190_T193_A0.5090.39
51_L58_L0.5060.38
26_A75_S0.5060.38
153_T156_A0.5020.38
139_A142_G0.5000.38
54_N182_T0.5000.38
100_D103_K0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yewA 3 0.7857 28.7 0.927 Contact Map
4phzA 3 0.7806 19.8 0.932 Contact Map
2wtpA 2 0.3469 16.4 0.935 Contact Map
2x3cA 2 0.5357 16.3 0.935 Contact Map
1g43A 1 0.7449 12.5 0.938 Contact Map
4bbjA 1 0.3061 9 0.942 Contact Map
2qsvA 1 0.5051 6.5 0.945 Contact Map
1spfA 1 0.1378 5 0.948 Contact Map
3c75A 1 0.5306 5 0.948 Contact Map
3isyA 1 0.5459 4.9 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0071 seconds.