Peptidase_M73 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Peptidase_M73 - Camelysin metallo-endopeptidase

PFAM:	PF12389	Sequences: SIKKKLGLGVASAALGASLIGGGTFAYFSDTETSNNTFAAGTLDLALGPTLTVNVSNLKPGDTVQRSFTLKNSGSLDIASVTLTTSYTVSDALGTNTTNDLGKHIKVTFLSNADKGTGPIYGTTLSDLKSTTPDLVSNAVIGSNLALSGGGLTAGATDHLRVTFTFPDNGEAGNTFQGDSLTLTWTFTATQRAGEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	196 (189)
Sequences:	1005 (859)
Seq/√Len:	62.5
META:	0.736

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
59_K	76_L	3.925	1.00
30_D	44_D	3.600	1.00
7_G	13_A	2.981	1.00
45_L	78_I	2.829	1.00
9_G	13_A	2.737	1.00
13_A	16_G	2.611	1.00
107_V	110_L	2.497	1.00
69_T	159_H	2.443	1.00
173_G	176_F	2.360	1.00
14_A	24_T	2.308	1.00
40_A	179_D	2.279	1.00
77_D	154_A	2.240	1.00
9_G	12_S	2.185	1.00
10_V	17_A	2.062	1.00
17_A	20_I	1.997	1.00
12_S	17_A	1.994	1.00
52_T	55_V	1.885	1.00
32_E	44_D	1.872	1.00
122_G	125_L	1.857	1.00
168_D	172_A	1.791	1.00
7_G	11_A	1.790	1.00
57_N	75_S	1.773	1.00
13_A	17_A	1.727	0.99
166_F	172_A	1.681	0.99
91_D	96_N	1.673	0.99
14_A	17_A	1.648	0.99
38_F	58_L	1.626	0.99
19_L	22_G	1.623	0.99
123_T	127_D	1.622	0.99
57_N	76_L	1.617	0.99
108_T	111_S	1.601	0.99
93_L	96_N	1.598	0.99
42_T	178_G	1.577	0.99
43_L	76_L	1.577	0.99
103_K	126_S	1.536	0.99
15_L	20_I	1.524	0.99
8_L	11_A	1.511	0.98
45_L	70_L	1.474	0.98
58_L	64_V	1.465	0.98
78_I	189_A	1.462	0.98
102_G	107_V	1.435	0.98
91_D	179_D	1.431	0.98
176_F	179_D	1.418	0.98
21_G	25_F	1.408	0.97
28_F	174_N	1.381	0.97
5_K	9_G	1.365	0.97
42_T	74_G	1.363	0.97
49_P	53_V	1.343	0.97
111_S	114_D	1.338	0.97
8_L	12_S	1.334	0.97
7_G	14_A	1.332	0.96
49_P	52_T	1.325	0.96
118_G	121_Y	1.299	0.96
6_L	9_G	1.286	0.96
99_N	103_K	1.276	0.95
68_F	187_F	1.276	0.95
91_D	94_G	1.270	0.95
86_S	186_T	1.258	0.95
9_G	16_G	1.252	0.95
102_G	108_T	1.233	0.95
92_A	179_D	1.231	0.95
101_L	110_L	1.220	0.94
170_G	173_G	1.219	0.94
134_D	138_N	1.216	0.94
107_V	111_S	1.202	0.94
102_G	110_L	1.202	0.94
108_T	112_N	1.186	0.93
99_N	105_I	1.181	0.93
170_G	174_N	1.163	0.93
145_L	148_S	1.155	0.92
72_N	76_L	1.152	0.92
90_S	94_G	1.146	0.92
98_T	175_T	1.127	0.91
14_A	19_L	1.122	0.91
166_F	169_N	1.122	0.91
65_Q	163_T	1.118	0.91
56_S	69_T	1.110	0.91
86_S	129_K	1.105	0.91
5_K	8_L	1.103	0.91
59_K	62_D	1.102	0.90
172_A	176_F	1.091	0.90
119_P	122_G	1.088	0.90
169_N	172_A	1.085	0.90
33_T	45_L	1.085	0.90
46_A	73_S	1.083	0.90
36_N	46_A	1.083	0.90
176_F	189_A	1.073	0.89
69_T	157_T	1.069	0.89
170_G	176_F	1.063	0.89
124_T	165_T	1.057	0.89
11_A	14_A	1.055	0.88
7_G	10_V	1.052	0.88
125_L	128_L	1.048	0.88
7_G	17_A	1.043	0.88
16_G	20_I	1.043	0.88
113_A	116_G	1.029	0.87
108_T	165_T	1.028	0.87
181_L	185_W	1.025	0.87
50_T	55_V	1.007	0.86
11_A	15_L	1.006	0.86
88_T	184_T	1.001	0.86
143_S	146_A	0.997	0.85
90_S	93_L	0.991	0.85
144_N	147_L	0.988	0.85
100_D	110_L	0.983	0.85
8_L	13_A	0.978	0.84
95_T	98_T	0.972	0.84
99_N	102_G	0.970	0.84
42_T	177_Q	0.968	0.84
18_S	23_G	0.967	0.84
141_I	147_L	0.966	0.84
65_Q	161_R	0.965	0.84
32_E	179_D	0.955	0.83
16_G	19_L	0.953	0.83
46_A	71_K	0.945	0.82
142_G	147_L	0.943	0.82
12_S	15_L	0.943	0.82
51_L	55_V	0.941	0.82
14_A	18_S	0.939	0.82
50_T	53_V	0.919	0.80
114_D	117_T	0.917	0.80
80_S	190_T	0.916	0.80
30_D	34_S	0.914	0.80
16_G	21_G	0.912	0.80
146_A	149_G	0.911	0.80
96_N	99_N	0.898	0.79
36_N	57_N	0.894	0.79
24_T	28_F	0.893	0.79
46_A	68_F	0.891	0.78
119_P	125_L	0.887	0.78
109_F	112_N	0.881	0.78
23_G	31_T	0.881	0.78
20_I	24_T	0.876	0.77
105_I	110_L	0.875	0.77
116_G	121_Y	0.873	0.77
110_L	160_L	0.868	0.77
105_I	108_T	0.867	0.76
96_N	100_D	0.864	0.76
104_H	107_V	0.858	0.76
91_D	95_T	0.850	0.75
106_K	111_S	0.844	0.74
173_G	185_W	0.844	0.74
133_P	137_S	0.842	0.74
106_K	109_F	0.839	0.74
9_G	17_A	0.839	0.74
46_A	81_V	0.838	0.74
34_S	179_D	0.831	0.73
87_Y	91_D	0.829	0.73
102_G	105_I	0.825	0.73
15_L	24_T	0.823	0.73
118_G	122_G	0.823	0.73
86_S	184_T	0.821	0.72
130_S	140_V	0.820	0.72
106_K	112_N	0.817	0.72
5_K	12_S	0.813	0.72
29_S	59_K	0.812	0.72
45_L	189_A	0.812	0.72
105_I	109_F	0.809	0.71
29_S	43_L	0.807	0.71
103_K	107_V	0.804	0.71
7_G	32_E	0.803	0.71
120_I	123_T	0.801	0.71
142_G	148_S	0.799	0.70
26_A	32_E	0.799	0.70
108_T	163_T	0.794	0.70
14_A	20_I	0.792	0.70
19_L	26_A	0.786	0.69
6_L	13_A	0.782	0.69
134_D	137_S	0.779	0.68
43_L	180_S	0.777	0.68
118_G	136_V	0.771	0.68
98_T	101_L	0.769	0.67
44_D	73_S	0.765	0.67
5_K	13_A	0.763	0.67
106_K	165_T	0.762	0.67
70_L	187_F	0.760	0.67
89_V	184_T	0.755	0.66
122_G	126_S	0.754	0.66
100_D	107_V	0.750	0.65
174_N	177_Q	0.749	0.65
23_G	29_S	0.749	0.65
103_K	108_T	0.746	0.65
109_F	114_D	0.743	0.65
77_D	153_T	0.742	0.65
118_G	127_D	0.733	0.64
124_T	128_L	0.729	0.63
135_L	138_N	0.728	0.63
10_V	18_S	0.727	0.63
99_N	107_V	0.727	0.63
120_I	125_L	0.726	0.63
126_S	129_K	0.718	0.62
88_T	152_L	0.715	0.62
120_I	126_S	0.707	0.61
33_T	184_T	0.703	0.60
22_G	26_A	0.693	0.59
7_G	12_S	0.693	0.59
113_A	119_P	0.691	0.59
97_T	175_T	0.688	0.59
43_L	78_I	0.685	0.58
118_G	125_L	0.684	0.58
10_V	21_G	0.683	0.58
117_T	120_I	0.681	0.58
5_K	20_I	0.673	0.57
70_L	78_I	0.670	0.57
27_Y	190_T	0.663	0.56
24_T	32_E	0.660	0.56
93_L	97_T	0.659	0.56
82_T	188_T	0.654	0.55
114_D	122_G	0.654	0.55
145_L	149_G	0.653	0.55
58_L	156_A	0.653	0.55
111_S	116_G	0.652	0.55
72_N	158_D	0.651	0.55
32_E	189_A	0.649	0.54
109_F	115_K	0.645	0.54
103_K	106_K	0.644	0.54
135_L	139_A	0.641	0.54
7_G	16_G	0.639	0.53
121_Y	124_T	0.637	0.53
90_S	97_T	0.635	0.53
39_A	75_S	0.634	0.53
37_T	54_N	0.629	0.52
113_A	118_G	0.622	0.51
6_L	10_V	0.618	0.51
103_K	110_L	0.616	0.51
117_T	123_T	0.615	0.51
94_G	97_T	0.614	0.50
110_L	113_A	0.607	0.50
122_G	127_D	0.606	0.50
9_G	19_L	0.603	0.49
67_S	159_H	0.602	0.49
154_A	193_A	0.601	0.49
172_A	175_T	0.601	0.49
128_L	131_T	0.598	0.49
45_L	187_F	0.598	0.49
79_A	82_T	0.595	0.48
16_G	83_L	0.592	0.48
93_L	99_N	0.590	0.48
125_L	129_K	0.589	0.48
11_A	19_L	0.587	0.47
94_G	100_D	0.585	0.47
116_G	125_L	0.585	0.47
62_D	83_L	0.583	0.47
62_D	66_R	0.582	0.47
96_N	103_K	0.580	0.47
27_Y	178_G	0.580	0.47
10_V	48_G	0.579	0.46
22_G	27_Y	0.576	0.46
44_D	179_D	0.574	0.46
27_Y	45_L	0.573	0.46
110_L	114_D	0.572	0.46
140_V	143_S	0.571	0.46
97_T	103_K	0.569	0.45
121_Y	125_L	0.568	0.45
116_G	122_G	0.564	0.45
59_K	192_R	0.563	0.45
112_N	115_K	0.558	0.44
45_L	170_G	0.556	0.44
115_K	128_L	0.555	0.44
108_T	113_A	0.555	0.44
147_L	150_G	0.553	0.43
104_H	110_L	0.550	0.43
107_V	112_N	0.549	0.43
49_P	81_V	0.544	0.42
42_T	75_S	0.541	0.42
168_D	173_G	0.540	0.42
8_L	14_A	0.536	0.42
116_G	120_I	0.535	0.41
42_T	62_D	0.531	0.41
164_F	168_D	0.528	0.41
77_D	155_G	0.527	0.41
7_G	29_S	0.520	0.40
79_A	130_S	0.518	0.40
116_G	119_P	0.511	0.39
133_P	136_V	0.510	0.39
56_S	146_A	0.510	0.39
142_G	145_L	0.510	0.39
190_T	193_A	0.509	0.39
51_L	58_L	0.506	0.38
26_A	75_S	0.506	0.38
153_T	156_A	0.502	0.38
139_A	142_G	0.500	0.38
54_N	182_T	0.500	0.38
100_D	103_K	0.500	0.38

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1yewA	3	0.7857	28.7	0.927	Contact Map
4phzA	3	0.7806	19.8	0.932	Contact Map
2wtpA	2	0.3469	16.4	0.935	Contact Map
2x3cA	2	0.5357	16.3	0.935	Contact Map
1g43A	1	0.7449	12.5	0.938	Contact Map
4bbjA	1	0.3061	9	0.942	Contact Map
2qsvA	1	0.5051	6.5	0.945	Contact Map
1spfA	1	0.1378	5	0.948	Contact Map
3c75A	1	0.5306	5	0.948	Contact Map
3isyA	1	0.5459	4.9	0.949	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0066 seconds.