GREMLIN Database
PFO_beta_C - Pyruvate ferredoxin oxidoreductase beta subunit C terminal
PFAM: PF12367 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 66 (64)
Sequences: 11917 (7519)
Seq/√Len: 939.9
META: 0.949

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_E35_E3.6821.00
32_A35_E2.8151.00
18_Y43_K2.6581.00
18_Y45_P2.0761.00
36_K39_E2.0541.00
17_V46_I1.8991.00
27_P51_R1.8741.00
11_D15_E1.8701.00
30_R34_M1.7431.00
12_W16_R1.7121.00
56_T59_E1.7011.00
28_T51_R1.6751.00
31_E38_L1.6291.00
34_M38_L1.6101.00
19_K22_E1.5441.00
5_N8_N1.5071.00
19_K46_I1.4681.00
32_A36_K1.4401.00
2_V10_Y1.4051.00
29_D32_A1.3111.00
39_E43_K1.2581.00
10_Y14_K1.2511.00
55_P60_R1.2341.00
30_R38_L1.2101.00
20_L36_K1.1931.00
5_N9_T1.1441.00
25_H36_K1.1141.00
48_V51_R1.1071.00
40_W44_I1.0651.00
20_L25_H1.0431.00
17_V44_I1.0391.00
28_T52_E1.0351.00
39_E45_P1.0251.00
6_K9_T1.0041.00
57_Y61_L0.9561.00
33_A50_Y0.9371.00
8_N12_W0.9361.00
20_L49_F0.9341.00
18_Y39_E0.9271.00
5_N13_Y0.9251.00
36_K49_F0.8911.00
31_E34_M0.8671.00
28_T53_E0.8551.00
36_K45_P0.8521.00
18_Y23_D0.8421.00
58_E63_V0.8181.00
54_R60_R0.8131.00
39_E42_D0.8031.00
25_H33_A0.7991.00
35_E39_E0.7841.00
25_H29_D0.7791.00
26_D32_A0.7711.00
16_R42_D0.7671.00
56_T60_R0.7521.00
21_E24_G0.7471.00
13_Y61_L0.7381.00
26_D29_D0.7261.00
21_E36_K0.7071.00
12_W15_E0.7001.00
45_P49_F0.6961.00
11_D14_K0.6961.00
55_P59_E0.6861.00
30_R37_A0.6791.00
53_E59_E0.6611.00
10_Y17_V0.6541.00
35_E38_L0.6451.00
60_R63_V0.6361.00
16_R44_I0.6311.00
23_D43_K0.6281.00
2_V9_T0.6231.00
16_R43_K0.6201.00
37_A49_F0.6191.00
41_G44_I0.6151.00
8_N13_Y0.6141.00
6_K10_Y0.6121.00
17_V45_P0.6111.00
9_T13_Y0.6031.00
52_E56_T0.5941.00
14_K19_K0.5861.00
29_D33_A0.5841.00
1_C4_F0.5731.00
9_T12_W0.5731.00
8_N14_K0.5731.00
5_N12_W0.5601.00
25_H32_A0.5571.00
13_Y44_I0.5541.00
8_N57_Y0.5521.00
30_R50_Y0.5451.00
18_Y36_K0.5411.00
58_E64_L0.5361.00
5_N10_Y0.5361.00
52_E55_P0.5351.00
37_A40_W0.5301.00
44_I49_F0.5211.00
23_D36_K0.5031.00
45_P48_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c2gA 1 0.6061 9.4 0.87 Contact Map
4pa0A 1 0.9242 8.1 0.874 Contact Map
4qbdA 1 0.9242 7.9 0.874 Contact Map
1kk8A 1 0.9242 7.6 0.875 Contact Map
2oo9A 2 0.697 7.4 0.876 Contact Map
2datA 1 0.3636 7.4 0.876 Contact Map
2v26A 1 0.9394 6.6 0.879 Contact Map
1h7nA 5 0.7879 6.5 0.879 Contact Map
1r8jA 2 0.8182 6.5 0.88 Contact Map
2ycuA 1 0.9545 6.2 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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