GREMLIN Database
DNAJ_related - DNA-J related protein
PFAM: PF12339 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 128 (127)
Sequences: 828 (665)
Seq/√Len: 59.0
META: 0.653

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_T116_D5.3491.00
20_E50_H4.5851.00
62_D100_R3.4281.00
24_I53_L3.2111.00
65_W71_H3.1291.00
24_I49_T3.0951.00
106_W109_L3.0461.00
44_L117_V2.9201.00
113_D116_D2.7551.00
61_Q100_R2.6771.00
55_N106_W2.5841.00
8_L64_L2.1961.00
44_L48_R2.1691.00
117_V120_L2.1441.00
28_Q49_T2.1331.00
8_L12_R1.9871.00
47_F112_T1.9501.00
54_F102_Y1.9041.00
54_F77_L1.8281.00
14_H17_G1.8130.99
93_L97_D1.6030.99
114_E118_E1.5540.98
43_P118_E1.5180.98
102_Y112_T1.5130.98
14_H18_I1.4840.98
19_S22_E1.4670.98
18_I22_E1.4660.98
11_L15_P1.4330.97
73_Q82_L1.3650.96
42_D114_E1.3610.96
64_L81_L1.3010.95
41_S114_E1.2590.94
40_L117_V1.2420.94
35_F55_N1.2290.94
10_L26_A1.2030.93
112_T117_V1.1930.92
20_E24_I1.1920.92
61_Q106_W1.1820.92
56_A106_W1.1730.92
50_H54_F1.1490.91
49_T54_F1.1490.91
86_Y89_G1.1420.91
28_Q31_G1.1370.91
17_G80_R1.0570.87
66_E88_A1.0560.87
120_L123_S1.0540.87
45_A49_T1.0540.87
12_R64_L1.0420.86
42_D49_T1.0380.86
9_E16_A1.0330.86
2_P55_N1.0170.85
17_G76_P0.9950.84
74_I104_L0.9860.83
26_A29_E0.9850.83
50_H103_Y0.9800.83
24_I40_L0.9770.82
51_F104_L0.9600.81
54_F75_S0.9590.81
4_L63_Q0.9550.81
32_Y76_P0.9520.81
76_P79_I0.9520.81
18_I121_L0.9450.80
96_D101_D0.9440.80
108_N111_E0.9160.78
24_I28_Q0.9130.78
105_D108_N0.9070.78
117_V121_L0.8980.77
21_Y77_L0.8970.77
25_K28_Q0.8920.76
12_R17_G0.8920.76
10_L18_I0.8800.75
7_L59_Q0.8690.74
47_F121_L0.8680.74
73_Q80_R0.8580.73
2_P54_F0.8550.73
17_G53_L0.8440.72
55_N120_L0.8440.72
63_Q67_E0.8400.72
6_P12_R0.8350.71
4_L113_D0.8200.70
107_S110_E0.8190.70
40_L49_T0.8140.70
42_D45_A0.8100.69
3_L36_P0.7990.68
105_D110_E0.7910.67
74_I77_L0.7900.67
19_S58_Y0.7880.67
80_R83_P0.7740.66
31_G34_L0.7670.65
87_Q91_A0.7650.65
44_L112_T0.7650.65
19_S33_G0.7650.65
51_F74_I0.7630.64
56_A59_Q0.7610.64
18_I26_A0.7600.64
38_L41_S0.7590.64
6_P10_L0.7450.63
7_L56_A0.7450.63
13_A89_G0.7450.63
5_D48_R0.7440.63
20_E35_F0.7430.62
73_Q100_R0.7410.62
33_G95_E0.7370.62
10_L13_A0.7360.62
107_S114_E0.7300.61
64_L100_R0.7110.59
61_Q71_H0.7090.59
54_F76_P0.7050.58
53_L56_A0.7020.58
91_A97_D0.7010.58
96_D122_D0.6980.58
53_L76_P0.6980.58
44_L47_F0.6950.57
29_E42_D0.6890.57
40_L97_D0.6880.57
10_L107_S0.6830.56
7_L14_H0.6820.56
24_I44_L0.6810.56
44_L120_L0.6810.56
84_S101_D0.6810.56
7_L38_L0.6800.56
21_Y25_K0.6760.55
35_F49_T0.6730.55
88_A126_Q0.6720.55
87_Q122_D0.6710.55
51_F102_Y0.6670.54
14_H26_A0.6650.54
46_L52_L0.6620.54
67_E107_S0.6580.53
54_F79_I0.6490.52
21_Y120_L0.6450.52
102_Y121_L0.6440.52
18_I73_Q0.6420.51
21_Y48_R0.6370.51
26_A87_Q0.6290.50
35_F53_L0.6180.49
10_L14_H0.6150.48
19_S53_L0.6130.48
113_D119_R0.6130.48
64_L70_G0.6130.48
118_E122_D0.6120.48
11_L81_L0.6100.48
76_P93_L0.6080.48
4_L7_L0.6050.47
116_D119_R0.6030.47
102_Y108_N0.5960.46
87_Q94_A0.5950.46
55_N64_L0.5940.46
12_R69_W0.5910.46
94_A101_D0.5880.45
26_A30_Q0.5850.45
4_L10_L0.5790.44
35_F50_H0.5770.44
117_V123_S0.5760.44
99_L120_L0.5690.43
18_I50_H0.5690.43
68_G71_H0.5660.43
9_E30_Q0.5640.43
108_N125_W0.5610.42
19_S24_I0.5600.42
87_Q90_S0.5590.42
59_Q108_N0.5590.42
13_A23_L0.5540.42
68_G90_S0.5530.42
9_E13_A0.5420.40
5_D8_L0.5420.40
19_S73_Q0.5420.40
51_F108_N0.5410.40
109_L113_D0.5380.40
16_A80_R0.5340.40
23_L30_Q0.5340.40
104_L112_T0.5330.39
12_R16_A0.5320.39
19_S75_S0.5300.39
27_L52_L0.5300.39
51_F125_W0.5290.39
116_D120_L0.5270.39
11_L128_Y0.5230.38
24_I50_H0.5190.38
5_D68_G0.5170.38
115_E119_R0.5140.37
70_G75_S0.5100.37
54_F106_W0.5080.37
52_L106_W0.5080.37
20_E103_Y0.5050.37
2_P5_D0.5040.36
86_Y90_S0.5030.36
53_L75_S0.5020.36
21_Y76_P0.5020.36
4_L59_Q0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3odnA 1 0.7266 23.3 0.922 Contact Map
2gaiA 1 0.875 22 0.923 Contact Map
4ywtA 1 0.8438 20.8 0.924 Contact Map
2qwoB 1 0.25 15.6 0.928 Contact Map
1mw9X 1 0.875 12.7 0.931 Contact Map
3ag7A 1 0.2891 10.7 0.933 Contact Map
4cgyA 1 0.8828 9.9 0.934 Contact Map
1gkuB 1 0.875 6.5 0.94 Contact Map
1t92A 2 0.3906 6.2 0.94 Contact Map
2d4yA 1 0.3906 6.1 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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