GREMLIN Database
T4_baseplate - T4 bacteriophage base plate protein
PFAM: PF12322 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 205 (203)
Sequences: 5822 (4379)
Seq/√Len: 307.4
META: 0.986

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_K192_E3.4121.00
76_E91_E3.1711.00
93_N96_D3.0311.00
184_K194_E3.0071.00
2_E11_K2.7751.00
78_N89_E2.6971.00
73_T91_E2.6921.00
182_T194_E2.6741.00
163_N166_Q2.5101.00
113_G139_Y2.4581.00
178_K198_E2.3611.00
80_T87_E2.3571.00
3_L61_L2.3571.00
184_K192_E2.2471.00
42_K51_D2.2401.00
115_K137_Q2.2391.00
132_A156_D2.2211.00
78_N87_E2.2001.00
147_A155_L2.1221.00
111_D141_G2.0481.00
117_K136_D2.0241.00
107_K139_Y2.0171.00
56_F118_Y1.9881.00
83_D191_V1.9761.00
43_Q47_N1.9711.00
86_E188_K1.9521.00
105_K115_K1.9341.00
33_D36_Q1.9321.00
182_T196_V1.9071.00
105_K113_G1.8751.00
13_K39_N1.8401.00
129_D152_K1.8361.00
180_S198_E1.8351.00
146_D149_D1.7631.00
115_K136_D1.7571.00
197_L202_S1.7121.00
84_C187_C1.6801.00
140_D143_E1.6791.00
76_E89_E1.6671.00
31_S36_Q1.6651.00
104_N115_K1.6641.00
107_K113_G1.6111.00
140_D145_Y1.6111.00
64_N95_D1.6091.00
4_T11_K1.5941.00
165_K169_K1.5771.00
132_A152_K1.5661.00
24_I40_A1.5431.00
7_S56_F1.5401.00
137_Q144_V1.5241.00
2_E13_K1.5211.00
171_Q175_E1.5141.00
185_V193_S1.5131.00
169_K172_K1.5051.00
117_K123_D1.4741.00
186_K190_G1.4651.00
39_N43_Q1.4541.00
84_C189_C1.4501.00
7_S57_D1.4301.00
180_S196_V1.4261.00
4_T9_G1.3871.00
147_A150_F1.3831.00
107_K110_D1.3601.00
153_K157_E1.3471.00
156_D160_E1.3041.00
64_N67_A1.2921.00
133_S152_K1.2801.00
88_V185_V1.2771.00
2_E39_N1.2771.00
45_I49_I1.2761.00
172_K175_E1.2681.00
135_I159_I1.2451.00
60_Y64_N1.2411.00
82_P193_S1.2361.00
51_D122_D1.2061.00
5_L54_P1.1681.00
165_K168_K1.1611.00
114_I170_I1.1471.00
3_L14_Y1.1451.00
67_A95_D1.1431.00
75_V94_L1.1261.00
168_K171_Q1.1251.00
123_D133_S1.1211.00
3_L60_Y1.1091.00
46_K50_V1.0941.00
64_N98_K1.0881.00
72_E95_D1.0761.00
44_I48_C1.0601.00
164_S168_K1.0411.00
46_K51_D1.0341.00
68_K72_E1.0281.00
107_K111_D1.0251.00
158_F161_S1.0231.00
15_R21_E1.0221.00
5_L8_T1.0191.00
112_I140_D1.0171.00
1_Y4_T1.0101.00
53_L61_L1.0081.00
67_A94_L1.0081.00
73_T93_N1.0011.00
138_I147_A0.9971.00
36_Q39_N0.9951.00
80_T85_G0.9941.00
117_K120_S0.9931.00
137_Q146_D0.9911.00
64_N68_K0.9871.00
102_H176_T0.9851.00
77_L92_I0.9831.00
168_K172_K0.9791.00
102_H172_K0.9461.00
81_C193_S0.9451.00
138_I150_F0.9301.00
43_Q46_K0.9251.00
14_Y68_K0.9241.00
129_D132_A0.9221.00
79_V185_V0.9181.00
150_F154_E0.9151.00
81_C187_C0.9131.00
81_C84_C0.8911.00
58_I121_L0.8901.00
129_D156_D0.8871.00
20_K160_E0.8871.00
15_R18_L0.8821.00
111_D140_D0.8821.00
132_A155_L0.8761.00
172_K176_T0.8751.00
45_I50_V0.8711.00
45_I58_I0.8691.00
3_L12_I0.8581.00
108_L166_Q0.8581.00
134_C174_F0.8581.00
79_V90_V0.8501.00
45_I65_I0.8471.00
97_I181_H0.8451.00
106_I116_M0.8421.00
6_P60_Y0.8401.00
72_E93_N0.8371.00
189_C193_S0.8361.00
68_K95_D0.8341.00
145_Y150_F0.8311.00
187_C193_S0.8121.00
81_C189_C0.8091.00
32_E36_Q0.8061.00
63_L179_L0.8041.00
34_E201_Q0.8021.00
96_D181_H0.7971.00
146_D150_F0.7961.00
151_T154_E0.7961.00
59_E199_G0.7941.00
34_E38_I0.7931.00
2_E35_K0.7931.00
60_Y99_V0.7931.00
125_D129_D0.7891.00
84_C88_V0.7800.99
63_L94_L0.7710.99
105_K139_Y0.7700.99
187_C191_V0.7690.99
147_A152_K0.7680.99
128_F160_E0.7670.99
40_A48_C0.7600.99
3_L64_N0.7510.99
152_K156_D0.7460.99
115_K139_Y0.7380.99
12_I49_I0.7380.99
113_G140_D0.7350.99
109_T112_I0.7340.99
157_E161_S0.7330.99
126_Q129_D0.7320.99
38_I42_K0.7270.99
152_K155_L0.7260.99
127_I131_I0.7250.99
5_L61_L0.7230.99
17_F26_L0.7150.99
198_E202_S0.7120.99
157_E160_E0.7100.99
81_C88_V0.7060.99
17_F70_V0.7060.99
36_Q40_A0.7040.99
158_F162_L0.6980.99
150_F153_K0.6950.99
166_Q169_K0.6940.99
81_C185_V0.6920.99
150_F155_L0.6910.99
5_L12_I0.6880.99
136_D146_D0.6870.99
173_F176_T0.6850.99
6_P99_V0.6830.99
103_T176_T0.6820.99
118_Y173_F0.6780.99
1_Y81_C0.6750.99
45_I53_L0.6750.99
81_C191_V0.6740.99
120_S123_D0.6730.98
8_T11_K0.6720.98
103_T108_L0.6720.98
63_L97_I0.6690.98
153_K156_D0.6660.98
77_L197_L0.6590.98
119_P134_C0.6550.98
82_P195_V0.6500.98
83_D187_C0.6500.98
73_T76_E0.6480.98
125_D156_D0.6480.98
24_I47_N0.6460.98
185_V191_V0.6460.98
185_V189_C0.6440.98
141_G145_Y0.6420.98
24_I43_Q0.6400.98
28_A40_A0.6400.98
112_I138_I0.6390.98
82_P191_V0.6390.98
24_I27_M0.6380.98
119_P177_P0.6310.98
151_T155_L0.6310.98
164_S167_F0.6270.98
135_I138_I0.6270.98
135_I147_A0.6260.98
138_I145_Y0.6200.97
98_K181_H0.6180.97
48_C65_I0.6160.97
22_E168_K0.6150.97
139_Y145_Y0.6130.97
199_G202_S0.6130.97
57_D99_V0.6110.97
67_A72_E0.6100.97
14_Y65_I0.6100.97
66_R70_V0.6100.97
11_K35_K0.6080.97
162_L166_Q0.6070.97
138_I155_L0.6040.97
50_V54_P0.6040.97
132_A136_D0.6030.97
17_F22_E0.5990.97
128_F156_D0.5970.97
12_I61_L0.5920.97
4_T8_T0.5920.97
38_I55_T0.5900.97
61_L65_I0.5850.96
79_V195_V0.5840.96
99_V179_L0.5830.96
39_N46_K0.5830.96
52_K120_S0.5810.96
6_P57_D0.5770.96
102_H175_E0.5770.96
90_V183_I0.5770.96
129_D133_S0.5750.96
79_V193_S0.5740.96
135_I155_L0.5730.96
36_Q43_Q0.5730.96
183_I197_L0.5700.96
65_I68_K0.5700.96
52_K117_K0.5680.96
42_K46_K0.5660.96
41_I200_L0.5650.96
183_I196_V0.5640.96
24_I36_Q0.5620.95
46_K49_I0.5620.95
44_I47_N0.5590.95
113_G137_Q0.5570.95
151_T156_D0.5560.95
37_I41_I0.5550.95
42_K122_D0.5550.95
14_Y64_N0.5530.95
84_C193_S0.5520.95
165_K172_K0.5520.95
170_I174_F0.5500.95
167_F170_I0.5490.95
6_P9_G0.5490.95
81_C85_G0.5460.95
130_L134_C0.5460.95
86_E187_C0.5450.95
5_L56_F0.5440.95
53_L58_I0.5440.95
92_I181_H0.5430.95
116_M173_F0.5420.95
114_I158_F0.5410.94
113_G144_V0.5400.94
6_P11_K0.5360.94
66_R71_G0.5360.94
132_A147_A0.5350.94
106_I169_K0.5310.94
28_A31_S0.5300.94
29_L38_I0.5260.94
52_K122_D0.5250.94
103_T106_I0.5230.93
141_G144_V0.5230.93
55_T124_F0.5220.93
93_N181_H0.5220.93
40_A44_I0.5210.93
59_E121_L0.5210.93
133_S136_D0.5200.93
25_L44_I0.5190.93
118_Y176_T0.5180.93
82_P85_G0.5180.93
88_V187_C0.5170.93
181_H195_V0.5160.93
108_L112_I0.5150.93
136_D139_Y0.5130.93
103_T107_K0.5130.93
35_K39_N0.5120.93
16_P19_V0.5100.93
179_L202_S0.5020.92
50_V61_L0.5010.92
27_M31_S0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wwlA 1 0.2488 10.1 0.94 Contact Map
1wiiA 1 0.3756 9 0.942 Contact Map
2p14A 1 0.3122 8.5 0.942 Contact Map
3f6nA 3 0.3561 6.8 0.945 Contact Map
2k2dA 1 0.2049 6 0.946 Contact Map
3lywA 1 0.1268 4.5 0.949 Contact Map
2jnsA 1 0.4293 4.4 0.949 Contact Map
4aybP 1 0.2098 4.3 0.95 Contact Map
4aboI 1 0.2634 4.2 0.95 Contact Map
1pqvS 1 0.4195 4.2 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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