GREMLIN Database
DUF3634 - Protein of unknown function (DUF3634)
PFAM: PF12321 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 102 (90)
Sequences: 693 (546)
Seq/√Len: 57.5
META: 0.788

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_V31_V3.4131.00
13_W17_R3.2011.00
57_G76_I2.6871.00
22_F61_G2.6551.00
72_F81_Q2.5711.00
42_F46_L2.1991.00
53_P80_Q2.1791.00
26_V50_A2.0981.00
26_V57_G2.0421.00
82_Q86_N1.9861.00
61_G68_A1.9731.00
52_R83_R1.9571.00
46_L84_L1.8681.00
7_A11_V1.8120.99
50_A55_V1.7670.99
23_V58_T1.5680.98
22_F42_F1.5640.98
40_P44_A1.5580.98
64_R69_R1.5330.98
70_L88_F1.5320.98
20_E60_R1.4630.97
25_R32_R1.3940.97
70_L84_L1.3720.96
49_V87_V1.3660.96
3_V7_A1.3490.96
20_E42_F1.3460.96
15_V18_A1.3390.96
16_A19_R1.3310.95
13_W16_A1.3120.95
38_V42_F1.3110.95
53_P83_R1.2970.95
45_D87_V1.2910.95
12_L16_A1.2420.93
61_G70_L1.2380.93
71_V76_I1.2010.92
61_G88_F1.1930.92
57_G72_F1.1820.92
80_Q87_V1.1760.91
82_Q85_R1.1700.91
13_W18_A1.1510.91
89_P92_G1.0750.87
10_L14_L1.0750.87
9_A16_A1.0740.87
81_Q88_F1.0700.87
31_V46_L1.0610.87
83_R86_N1.0450.86
11_V14_L1.0420.86
23_V48_D1.0210.84
22_F70_L1.0100.84
48_D87_V1.0080.84
24_V48_D0.9720.81
12_L51_R0.9330.79
20_E23_V0.9000.76
77_P88_F0.8950.76
55_V76_I0.8830.75
11_V15_V0.8790.74
39_P42_F0.8740.74
12_L19_R0.8670.73
3_V12_L0.8520.72
20_E35_R0.8380.71
54_P84_L0.8270.70
77_P80_Q0.8070.68
27_R32_R0.8070.68
59_I72_F0.8000.67
14_L17_R0.7810.65
24_V38_V0.7680.64
14_L91_S0.7650.64
35_R60_R0.7650.64
7_A28_D0.7550.63
45_D74_G0.7540.63
24_V46_L0.7500.62
57_G74_G0.7490.62
26_V60_R0.7390.61
12_L17_R0.7320.60
41_A54_P0.7170.59
43_L72_F0.7170.59
62_V71_V0.7160.59
22_F38_V0.7120.58
11_V56_R0.7060.57
12_L15_V0.6930.56
49_V80_Q0.6920.56
81_Q84_L0.6810.55
41_A46_L0.6770.54
77_P81_Q0.6760.54
8_V32_R0.6750.54
59_I75_D0.6690.53
9_A19_R0.6680.53
26_V74_G0.6680.53
78_E89_P0.6670.53
63_R67_G0.6660.53
53_P78_E0.6570.52
48_D52_R0.6550.52
6_V83_R0.6540.52
67_G88_F0.6430.51
11_V16_A0.6400.50
3_V56_R0.6350.50
33_V68_A0.6330.50
36_G57_G0.6320.49
8_V19_R0.6320.49
5_L76_I0.6200.48
38_V44_A0.6190.48
38_V46_L0.6180.48
68_A74_G0.6170.48
30_R51_R0.6090.47
59_I89_P0.6080.47
68_A90_H0.6040.46
12_L45_D0.6030.46
55_V63_R0.6000.46
4_I7_A0.5960.45
61_G72_F0.5950.45
23_V57_G0.5850.44
12_L46_L0.5820.44
34_V65_G0.5810.44
23_V56_R0.5770.43
74_G78_E0.5720.43
6_V10_L0.5670.42
20_E39_P0.5610.42
24_V34_V0.5550.41
23_V42_F0.5500.41
67_G78_E0.5450.40
25_R77_P0.5450.40
24_V43_L0.5340.39
15_V19_R0.5300.38
59_I73_S0.5290.38
8_V35_R0.5260.38
80_Q83_R0.5250.38
7_A16_A0.5200.37
38_V43_L0.5180.37
47_R75_D0.5170.37
4_I16_A0.5170.37
3_V65_G0.5140.37
42_F88_F0.5130.37
75_D90_H0.5070.36
34_V87_V0.5020.36
7_A13_W0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1n6jG 1 0.2549 18.3 0.907 Contact Map
3thtA 3 0.9216 16 0.91 Contact Map
3j1rA 5 0.1667 11.1 0.916 Contact Map
1qpzA 2 0.5098 11.1 0.916 Contact Map
3jvdA 2 0.0196 8.6 0.92 Contact Map
3or1B 2 0.8824 8.2 0.92 Contact Map
3vthA 1 0.7647 8 0.921 Contact Map
3dbiA 2 0.0392 7.5 0.922 Contact Map
2hsgA 1 0.5098 7.2 0.923 Contact Map
4g9iA 1 0.7157 6.8 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0055 seconds.