GREMLIN Database
FAD-SLDH - Membrane bound FAD containing D-sorbitol dehydrogenase
PFAM: PF12318 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 161 (159)
Sequences: 927 (725)
Seq/√Len: 57.5
META: 0.672

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_L58_A7.9841.00
44_S115_W4.7191.00
151_R156_Y3.1851.00
47_L112_V3.0231.00
47_L108_A2.8411.00
146_P152_G2.6931.00
54_D133_D2.6601.00
145_K151_R2.5881.00
114_A120_V2.5361.00
144_L156_Y2.4291.00
69_D75_Q2.3451.00
128_V150_C2.3441.00
41_L53_L2.2051.00
57_L61_L2.1781.00
13_L16_A2.1541.00
10_L14_A2.1001.00
44_S58_A1.9681.00
48_T116_Y1.8130.99
144_L151_R1.7110.99
90_P93_D1.6880.99
140_V144_L1.5920.99
53_L135_L1.5410.98
71_Q75_Q1.5380.98
149_Y154_P1.5340.98
89_D93_D1.5330.98
16_A31_A1.5230.98
112_V116_Y1.5050.98
113_S117_L1.4880.98
145_K150_C1.4850.98
75_Q79_L1.4470.97
148_T154_P1.4360.97
121_G126_A1.3740.96
157_W161_P1.3640.96
116_Y139_P1.3560.96
50_R138_Q1.3480.96
72_F111_I1.3450.96
44_S53_L1.3450.96
121_G124_P1.3330.96
132_E136_M1.3310.95
52_D138_Q1.3230.95
119_V128_V1.3090.95
35_A74_A1.2810.94
155_G158_A1.2800.94
64_A114_A1.2720.94
53_L115_W1.2670.94
64_A120_V1.2530.94
71_Q74_A1.2490.94
135_L142_D1.2420.93
132_E156_Y1.2390.93
16_A22_A1.2070.92
128_V146_P1.1930.92
145_K148_T1.1890.92
128_V134_A1.1860.92
3_R7_L1.1860.92
40_F115_W1.1810.92
65_L110_A1.1690.91
144_L154_P1.1690.91
132_E148_T1.1570.91
84_A87_G1.1440.90
153_G156_Y1.1440.90
15_A18_A1.1250.90
60_R136_M1.1220.89
26_A31_A1.1210.89
81_A85_A1.1140.89
53_L111_I1.1080.89
142_D150_C1.1010.88
143_V156_Y1.0890.88
141_A144_L1.0720.87
61_L128_V1.0680.87
68_A110_A1.0560.86
91_V94_L1.0510.86
39_A77_A1.0470.86
143_V150_C1.0460.86
8_A13_L1.0420.86
152_G156_Y1.0380.85
80_A88_A1.0330.85
37_L62_L0.9880.82
65_L120_V0.9860.82
150_C153_G0.9840.82
136_M139_P0.9800.82
139_P146_P0.9800.82
13_L45_A0.9800.82
61_L114_A0.9690.81
66_A73_A0.9680.81
55_P74_A0.9670.81
111_I135_L0.9640.81
74_A78_A0.9540.80
134_A143_V0.9380.79
122_D125_D0.9340.79
67_A74_A0.9280.78
102_P105_A0.9220.78
45_A52_D0.9160.77
143_V151_R0.9130.77
16_A23_L0.9110.77
47_L116_Y0.9050.76
137_Y146_P0.9010.76
94_L97_A0.8950.76
143_V148_T0.8950.76
4_R7_L0.8920.75
11_A14_A0.8860.75
119_V126_A0.8830.75
98_D108_A0.8800.74
150_C154_P0.8790.74
128_V137_Y0.8730.74
114_A146_P0.8580.73
117_L147_P0.8530.72
142_D149_Y0.8510.72
18_A22_A0.8490.72
144_L160_K0.8480.72
146_P155_G0.8340.70
114_A117_L0.8240.69
137_Y144_L0.8210.69
145_K152_G0.8210.69
131_Y158_A0.8100.68
60_R63_A0.8080.68
5_R22_A0.8010.67
137_Y140_V0.7900.66
145_K156_Y0.7820.65
57_L74_A0.7770.65
19_L23_L0.7730.64
6_L10_L0.7720.64
49_G91_V0.7680.64
25_A35_A0.7680.64
117_L137_Y0.7580.63
144_L148_T0.7560.63
17_A22_A0.7550.63
105_A140_V0.7480.62
72_F83_A0.7450.62
146_P151_R0.7430.61
15_A19_L0.7390.61
133_D138_Q0.7360.61
35_A39_A0.7350.61
82_L104_L0.7330.60
108_A137_Y0.7310.60
63_A67_A0.7310.60
29_A34_A0.7310.60
5_R55_P0.7250.60
72_F76_L0.7200.59
64_A129_V0.7190.59
150_C155_G0.7180.59
31_A39_A0.7110.58
14_A18_A0.7100.58
107_L110_A0.7090.58
44_S135_L0.7010.57
118_G130_A0.6960.56
136_M140_V0.6930.56
137_Y155_G0.6890.56
6_L17_A0.6870.55
114_A142_D0.6870.55
130_A146_P0.6830.55
11_A21_S0.6810.55
46_L91_V0.6800.55
137_Y147_P0.6790.55
143_V158_A0.6730.54
72_F79_L0.6710.54
147_P156_Y0.6660.53
111_I122_D0.6650.53
49_G94_L0.6590.52
89_D94_L0.6580.52
42_A90_P0.6580.52
13_L17_A0.6570.52
14_A22_A0.6570.52
82_L86_R0.6550.52
89_D97_A0.6540.52
69_D72_F0.6490.51
149_Y153_G0.6460.51
26_A29_A0.6420.50
88_A92_D0.6360.50
46_L53_L0.6340.50
45_A84_A0.6320.49
152_G155_G0.6300.49
137_Y143_V0.6280.49
81_A84_A0.6260.49
9_G16_A0.6260.49
123_G126_A0.6240.49
20_P23_L0.6120.47
53_L58_A0.6090.47
130_A134_A0.6080.47
5_R21_S0.6070.47
34_A38_D0.6070.47
59_A74_A0.6050.46
6_L21_S0.6040.46
60_R149_Y0.6040.46
41_L115_W0.6020.46
156_Y161_P0.5990.46
20_P27_A0.5980.46
132_E149_Y0.5970.46
117_L150_C0.5960.45
128_V145_K0.5950.45
119_V127_R0.5950.45
117_L143_V0.5950.45
91_V112_V0.5940.45
117_L130_A0.5930.45
92_D95_L0.5930.45
151_R154_P0.5920.45
72_F147_P0.5920.45
20_P45_A0.5900.45
37_L58_A0.5870.44
54_D61_L0.5780.43
97_A100_P0.5730.43
33_A74_A0.5730.43
82_L101_D0.5710.43
10_L20_P0.5670.42
121_G148_T0.5650.42
60_R120_V0.5640.42
57_L129_V0.5580.41
6_L77_A0.5580.41
146_P150_C0.5550.41
62_L66_A0.5550.41
142_D147_P0.5530.41
136_M146_P0.5530.41
99_A117_L0.5520.41
75_Q107_L0.5460.40
134_A142_D0.5460.40
12_A16_A0.5440.40
97_A128_V0.5390.39
121_G129_V0.5360.39
102_P131_Y0.5350.39
18_A21_S0.5350.39
27_A31_A0.5340.39
85_A88_A0.5330.39
7_L38_D0.5320.39
95_L99_A0.5310.39
25_A28_A0.5300.38
20_P38_D0.5290.38
41_L44_S0.5260.38
8_A18_A0.5260.38
65_L72_F0.5230.38
53_L130_A0.5210.37
29_A32_A0.5210.37
5_R8_A0.5210.37
5_R78_A0.5120.37
89_D95_L0.5080.36
132_E146_P0.5070.36
3_R118_G0.5060.36
2_S11_A0.5050.36
56_A59_A0.5020.36
2_S5_R0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pq4B 1 0.205 77.4 0.894 Contact Map
1h2aS 1 0.6894 34.1 0.92 Contact Map
2wpnA 1 0.6273 29.1 0.923 Contact Map
3w36A 2 0.7702 25.2 0.925 Contact Map
1h6dA 8 0.6584 14.2 0.933 Contact Map
1q90R 1 0.1801 12.7 0.934 Contact Map
2vpzA 1 0.7702 12.3 0.935 Contact Map
3sbqA 2 0.3292 10.3 0.937 Contact Map
1kqfA 3 0.3789 10.1 0.937 Contact Map
4wedA 1 0.7267 9.4 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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